Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Kliewe, Felix; Siegerist, Florian; Hammer, Elke; Al-Hasani, Jaafar; Amling, Theodor; Hollemann, Jonas; Schindler, Maximilian; Drenic, Vedran; Simm, Stefan; Amann, Kerstin; Daniel, Christoph; Lindenmeyer, Maja; Hecker, Markus; Völker, Uwe; Endlich, Nicole (2024)
Kliewe, Felix; Siegerist, Florian; Hammer, Elke; Al-Hasani, Jaafar; Amling, Theodor...
Communications Biology 7 (1), 446.
DOI: 10.1038/s42003-024-06125-5
Open Access Peer Reviewed
Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in podocytes after mechanical stretch and relocalizes from focal adhesions to actin filaments. In zyxin knockout podocytes, we found that the loss of zyxin reduced the expression of vinculin and VASP as well as the expression of matrix proteins, such as fibronectin. This suggests that zyxin is a central player in the translation of mechanical forces in podocytes. In vivo, zyxin is highly up-regulated in patients suffering from diabetic nephropathy and in hypertensive DOCA-salt treated mice. Furthermore, zyxin loss in mice resulted in proteinuria and effacement of podocyte foot processes that was measured by super resolution microscopy. This highlights the essential role of zyxin for podocyte maintenance in vitro and in vivo, especially under mechanical stretch.
PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods.
Freilinger, Sebastian; Kohls, Niko; Kaemmerer, Harald (2024)
BMC Cardiovascular Disorders 24 (1), 181.
DOI: 10.1186/s12872-024-03833-y
Open Access Peer Reviewed
Simulationsgetrieben Auslegungs- und Optimierungsstrategie für den Anwendungsfall eines Axialventilators mit Leitapparat
Fritsche, Manuel (2024)
Dissertation. Friedrich-Alexander-Universität Erlangen-Nürnberg, 2024.
Peer Reviewed
Homo Narrans: From Information to Narratives
Leidner, Jochen L. (2024)
Invited Keynote, Seventh International Workshop on Narrative Extraction from Texts (Text2Story 2024) held in conjunction with the 46th European Conference on Information Retrieval (ECIR 2024), Glasgow, Scotland, UK, 23 March 2024.
Enzymatic machinery of wood-inhabiting fungi that degrade temperate tree species
Kipping, Lydia; Jehmlich, N.; Moll, Julia; Noll, Matthias; Gossner, Martin M.; Bossche, Tim van den; Edelmann, Pascal; Borken , W.; Hofrichter, M.; Kellner, H. (2024)
Kipping, Lydia; Jehmlich, N.; Moll, Julia; Noll, Matthias; Gossner, Martin M....
The ISME Journal 2024/18/1, wrae050.
DOI: 10.1093/ismejo/wrae050
Open Access Peer Reviewed
Versatile platform for mobile detection of environmental pollutants using DNA Quantum Clusters
Kluitmann, Jonas; Drese, Klaus Stefan (2024)
Vortrag auf dem 12th Workshop of Chemical and Biological Micro Laboratory Technology CBM2024 in Ilmenau, März 2024.
Environmental pollution is an ever-growing concern. Industrial sites as well as agricultural use areas can bear immense harmful burdens. Unintentionally improperly disposed of wastes as well as illegally dumped chemicals pose additional risks in the environment, while remains of pharmaceuticals are a regular concern in sources of drinking water. Pollutants such as PFAS and microplastics could even be detected in the most remote regions of the earth and are known for adverse effects on humans and their environment. Establishing a comprehensive overview of where pollution of which severity and with what substances occurs is thus important, so remediations can be planned and prioritized. This necessitates fast, versatile, reliable and cheap measurements, ideally directly at sampling sites.
A promising class of transducers for detecting a multitude of pollutants are DNA Quantum Clusters. QC:DNA are highly sensitive and selective transducers for many substances, showing responses in their fluorescent behaviors based on their chemical environment. Based on the specific design, QC:DNA can interact with different chemical species and exhibit tuned excitation and emission wavelengths.
For the use of such transducers, we present a fluorescence reader integrated around capillaries. The system is designed for easy and fast customization for a large range of excitation and emission wavelengths while focusing on system portability and striving for affordability. The microfluidic system controlling and performing the assay is based on droplet sequences to facilitate fast mixing while allowing for incubation times with minimal dispersion and enabling a temporary storage and a precise processing of samples.
Die Entwicklung von individueller, gesellschaftlicher und planetarischer Resilienz - Achtsamkeit und ihre Bedeutsamkeit für Umwelt-, Klimaschutz und Nachhaltigkeit
Kohls, Niko; Pollan, Sandra; Heinrich, Michael (2024)
Erfolgsformel Achtsamkeit: Bewusst führen, nachhaltig gewinnen, Weifenbach, M. 2024.
Peer Reviewed
Mesh shaders on AMD RDNA™ graphics cards: Procedural grass rendering
Faber, Carsten; Kuth, Bastian; Oberberger, Max; Meyer, Quirin (2024)
Open Access
Wärmepumpen in Mehrfamilienhäusern – Mythen & Einsatzmöglichkeiten bzw. -grenzen
Schaub, Michael (2024)
Online-Infoveranstaltung der ENERGIEregion Nürnberg e.V..
The healing seven: how architecture impacts health.
Koppen, Gemma (2024)
Ringvorlesung: Health, Environment and Architecture – Discourses from the Past, Challenges for the Present, Perspectives for the Future, University of Durham, Durham.
Die Superkraft der Resilienz: Wie wir lernen, gesund & stark zu bleiben
Kohls, Niko (2024)
Gefangen in der Positivitätsfalle: Wann das Immer-Glücklich-Sein gefährlich wird
Kohls, Niko (2024)
Gefangen in der Positivitätsfalle: Wann das Immer-Glücklich-Sein gefährlich wird.
Mesh shaders on AMD RDNA™ graphics cards: Font- and vector-art rendering with mesh shaders
Kuth, Bastian; Oberberger, Max; Meyer, Quirin (2024)
Open Access
Wärmepumpen im Wohngebäude-Bestand– Kältemittel, Einsatzgrenzen, Hybridsysteme
Schaub, Michael (2024)
Online-Tagung des BTGA „BEG und Großwärmepumpen - Übersicht und aktuelle Informationen“.
DOI: 10.13140/RG.2.2.29962.27847
Open Access
Tau targeting D-peptides as a potential therapeutic approach for Alzheimer’s Disease
Funke, Susanne A. (2024)
AD/PD Conference 2024, Lissabon.
Clinical Social Work in Germany: Development, current state and future challenges
Pauls, Helmut; Gabriel, Maite; Kröger, Christine; Wesenberg, Sandra; Gahleitner, S. (2024)
1. Aufl., ZKS Medien Verlag, Höchberg.
Peer Reviewed
Selbstfürsorge ist en vogue - aber zu viel davon kann uns schaden
Kohls, Niko (2024)
Focus Online: https://www.focus.de/experts/die-seele-ins-gleichgewicht-bringen-psychologe-mit-7-tipps-wird-selbstfuersorge-zur-routine_id_259726954.html.
Frequency-Resolved High-Frequency Broadband Measurement of Acoustic Longitudinal Waves by Laser-Based Excitation and Detection
Brand, Felix; Drese, Klaus Stefan (2024)
Sensors 24 (5), 1630.
DOI: 10.3390/s24051630
Open Access Peer Reviewed
Optoacoustics is a metrology widely used for material characterisation. In this study, a measurement setup for the selective determination of the frequency-resolved phase velocities and attenuations of longitudinal waves over a wide frequency range (3-55 MHz) is presented. The ultrasonic waves in this setup were excited by a pulsed laser within an absorption layer in the thermoelastic regime and directed through a layer of water onto a sample. The acoustic waves were detected using a self-built adaptive interferometer with a photorefractive crystal. The instrument transmits compression waves only, is low-contact, non-destructive, and has a sample-independent excitation. The limitations of the approach were studied both by simulation and experiments to determine how the frequency range and precision can be improved. It was shown that measurements are possible for all investigated materials (silicon, silicone, aluminium, and water) and that the relative error for the phase velocity is less than 0.2%.
Seminar "ChatGPT an der Hochschule"
Holtorf, Christian; Rottmann, Pauline; Hesel, Charlotte (2024)
Beitrag zur vhb-Ideenwerkstatt „KI-Hochschullehre in der Praxis“. Online unter: https://oer.vhb.org/edu-sharing/components/render/22ea73c6-772b-4a11-80ca-bffbe093d2d7.
Open Access Peer Reviewed
Tree species-specific wood traits control diazotrophic community composition in deadwood
Hossen, Shakhawat; Groß , C.; Stapf, D.; Borken , W.; Noll, Matthias (2024)
International Biodeterioration & Biodegradation 187, 105723 .
DOI: 10.1016/j.ibiod.2023.105723
Peer Reviewed
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