FNG: Publikationen

Zyxin is important for the stability and function of podocytes, especially during mechanical stretch

Kliewe, Felix; Siegerist, Florian; Hammer, Elke; Al-Hasani, Jaafar; Amling, Theodor...

Communications Biology 7 (1), 446.
DOI: 10.1038/s42003-024-06125-5

Open Access Peer Reviewed

ABSTRACT

Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in podocytes after mechanical stretch and relocalizes from focal adhesions to actin filaments. In zyxin knockout podocytes, we found that the loss of zyxin reduced the expression of vinculin and VASP as well as the expression of matrix proteins, such as fibronectin. This suggests that zyxin is a central player in the translation of mechanical forces in podocytes. In vivo, zyxin is highly up-regulated in patients suffering from diabetic nephropathy and in hypertensive DOCA-salt treated mice. Furthermore, zyxin loss in mice resulted in proteinuria and effacement of podocyte foot processes that was measured by super resolution microscopy. This highlights the essential role of zyxin for podocyte maintenance in vitro and in vivo, especially under mechanical stretch.

PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods.

Freilinger, Sebastian; Kohls, Niko; Kaemmerer, Harald (2024)

BMC Cardiovascular Disorders 24 (1), 181.
DOI: 10.1186/s12872-024-03833-y

Open Access Peer Reviewed

Enzymatic machinery of wood-inhabiting fungi that degrade temperate tree species

Kipping, Lydia; Jehmlich, N.; Moll, Julia; Noll, Matthias; Gossner, Martin M....

The ISME Journal 2024/18/1, wrae050.
DOI: 10.1093/ismejo/wrae050

Open Access Peer Reviewed

Die Entwicklung von individueller, gesellschaftlicher und planetarischer Resilienz - Achtsamkeit und ihre Bedeutsamkeit für Umwelt-, Klimaschutz und Nachhaltigkeit

Kohls, Niko; Pollan, Sandra; Heinrich, Michael (2024)

Erfolgsformel Achtsamkeit: Bewusst führen, nachhaltig gewinnen, Hrsg. Weifenbach, M., Litego Verlag 2024.

Peer Reviewed

Ultrasonic Interferometric Procedure for Quantifying Prosthesis Loosening

Lützelberger, Jan (2024)

Invited Talk, 87th Annual Meeting of the DPG - Deutsche Physikalische Gesellschaft, Berlin, 2024.

ABSTRACT

Loosening of an artificial hip joint is a frequent complication in orthopedics and trauma surgery. Due to a lack of accuracy, conventional diagnostic methods such as projection radiography cannot reliably diagnose loosening in its early stages or detect whether it is associated with the formation of a biofilm in the bone-implant interface.

In this work, we developed an ultrasonic measurement procedure for quantifying the thickness of the layer between bone and prosthesis as a correlate to loosening. In principle, it also allows for the material characterization of the interface. An analytical model for the reflection of sound waves in a three-layer system was combined with a new data processing method to face the challenges of the specific medical application. By non-linear fitting the theoretical prediction of the model to the actual shape of the reflected sound waves in frequency domain, the thickness of the interlayer can be determined and predictions about its physical properties are possible. The presented approach was successfully applied to idealized test systems and a bone-implant system for thickness determination in the range of approx. 200 µm to 2 mm [1].

The talk will focus on the physical background and the key concepts of the procedure as well as on representative experiments, but also highlight its future potential in medical application.

[1] J. Lützelberger et al., Sensors 23, 5942 (2023)

Die Superkraft der Resilienz: Wie wir lernen, gesund & stark zu bleiben

Kohls, Niko (2024)

Gefangen in der Positivitätsfalle: Wann das Immer-Glücklich-Sein gefährlich wird

Kohls, Niko (2024)

Gefangen in der Positivitätsfalle: Wann das Immer-Glücklich-Sein gefährlich wird.

Tau targeting D-peptides as a potential therapeutic approach for Alzheimer’s Disease

Funke, Susanne A. (2024)

AD/PD Conference 2024, Lissabon.

Selbstfürsorge ist en vogue - aber zu viel davon kann uns schaden

Kohls, Niko (2024)

Focus Online: https://www.focus.de/experts/die-seele-ins-gleichgewicht-bringen-psychologe-mit-7-tipps-wird-selbstfuersorge-zur-routine_id_259726954.html.

Frequency-Resolved High-Frequency Broadband Measurement of Acoustic Longitudinal Waves by Laser-Based Excitation and Detection

Brand, Felix; Drese, Klaus Stefan (2024)

Sensors 24 (5), 1630.
DOI: 10.3390/s24051630

Open Access Peer Reviewed

ABSTRACT

Optoacoustics is a metrology widely used for material characterisation. In this study, a measurement setup for the selective determination of the frequency-resolved phase velocities and attenuations of longitudinal waves over a wide frequency range (3-55 MHz) is presented. The ultrasonic waves in this setup were excited by a pulsed laser within an absorption layer in the thermoelastic regime and directed through a layer of water onto a sample. The acoustic waves were detected using a self-built adaptive interferometer with a photorefractive crystal. The instrument transmits compression waves only, is low-contact, non-destructive, and has a sample-independent excitation. The limitations of the approach were studied both by simulation and experiments to determine how the frequency range and precision can be improved. It was shown that measurements are possible for all investigated materials (silicon, silicone, aluminium, and water) and that the relative error for the phase velocity is less than 0.2%.

Beratung von pflegenden Angehörigen: Welche Anlaufstellen gibt es?

Esslinger, Adelheid Susanne (2024)

MMW Münchner Medizinihsce Wochenzeitschrift (3), 42-44.

Peer Reviewed

Tree species-specific wood traits control diazotrophic community composition in deadwood

Hossen, Shakhawat; Groß , C.; Stapf, D.; Borken , W.; Noll, Matthias (2024)

International Biodeterioration & Biodegradation 187, 105723 .
DOI: 10.1016/j.ibiod.2023.105723

Peer Reviewed

Mirror-image phage display for the selection of D-amino acid peptide ligands as potential therapeutics

Funke, Susanne A.; Malhis, Marwa (2024)

Current Protocolls 2024 (4), e957.

Open Access Peer Reviewed

Neues Verfahren zeigt Lockerung von Hüftgelenken im Mikrometerbereich

Reckter, Bettina (2024)

VDI nachrichten, 2024..

Künstliche Intelligenz: Trends, Gefahren und Chancen

Interview für Radio Plassenburg, Sendung Heimat ist..., 7.2.2024.

Biological nitrogen fixation, diversity and community structure of diazotrophs in two mosses in 25 temperate forests

Groß , C.; Hossen, Shakhawat; Dittrich, S.; Knorr, K.-H.; Borken , W....

Environmental Microbiology 26, e16555.
DOI: 10.1111/1462-2920.16555

Open Access Peer Reviewed

Vorstellung des Forschungsprojekts AI4Coping

Meißner, Karin; Grubert, Jens (2024)

Interview im TV Oberfranken, Sendung 4you: Das neue Hochschulmagazin.

Open Access

ABSTRACT

Quelle: TV Oberfranken

Poultry litter biochar soil amendment affects microbial community structures, promotes phosphorus cycling and growth of barley (Hordeum vulgare).

Deinert, L.; Hossen, Shakhawat; Ikoyi, I.; Kwapinksi, W.; Noll, Matthias...

European Journal of Soil Biology 120, 103591.
DOI: 10.1016/j.ejsobi.2023.103591

Peer Reviewed

Active soil microbial composition and proliferation are directly affected by the presence of biocides from building materials

Kalkhof, Stefan; Reiß, Fabienne; Kiefer, Nadine; Purahong, Witoon; Borken , W....

Science of the Total Environment 912, 168689.
DOI: 10.1016/j.scitotenv.2023.168689

Peer Reviewed

Mapping expectancy-based appetitive placebo effects onto the brain in women

Khalid, Iraj ; Rodrigues, Belina ; Dreyfus, Hippolyte ; Frileux, Solène ...

Nature Communications 15, 248 | 1-16.
DOI: 10.1038/s41467-023-44569-1

Open Access Peer Reviewed

Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)

Hochschule Coburg

Friedrich-Streib-Str. 2
96450 Coburg

Support of publications
Jakob Hanke
Forschungsreferent
T +49 9561 317 360
jakob.hanke[at]hs-coburg.de