FNG: Publikationen

Encapsulated biocides in façade materials impact leaching and UV stability, resulting in lower aquatic toxicity of the eluates

Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine...

Environmental Science and Pollution Research 2025 (32), 16324-16339.
DOI: 10.1093/etojnl/vgaf156

Peer Reviewed

Neuroenhancement unter Studierenden im ländlichen Raum–eine Querschnittstudie zu Prävalenz, Genderunterschieden und Beweggründen

Engel, Katharina; Meißner, Karin (2025)

Prävention und Gesundheitsförderung 20 (3), 421-427.
DOI: 10.1007/s11553-024-01139-7

Open Access Peer Reviewed

Sitzt die Hüftprothese? Lockerungserkennung mit Ultraschall

Lützelberger, Jan; Franck, Alexander; Drese, Klaus Stefan (2025)

Zeitungsartikel, Management & Krankenhaus 8-9, 2025.

Systematic Comparison of Bone Proteome Extraction Methods to Allow for Integrated Proteomics–Metabolomics Correlation

Wiltzsch, Vivien; Schmidt, Johannes; Adamowicz, Klaudia; Lauterbach, Theresa...

Journal of Proteome Research 24 (9), 4362–4376.
DOI: 10.1021/acs.jproteome.4c01060

Peer Reviewed

Neurocognitive Factors in Spiritual Experiences and Practices

Kohls, Niko; Giordano, James (2025)

, 1–13.
DOI: 10.1007/978-3-031-38971-9_1976-1

Peer Reviewed

Psychologie des Älterwerdens

Kohls, Niko (2025)

Wissen für Alle by Hochschule Coburg: Mit 66 Jahren .... Äter werden mit Qualität.

Forgiveness and Physical Health: A Review of Theory and Evidence

Toussaint, Loren; Webb, Jon; Hirsch, Jameson; Kohls, Niko; Offenbaecher, Martin...

, 245–268.
DOI: 10.1007/978-3-031-89095-6_11

Peer Reviewed

ABSTRACT

This chapter offers an overview of the forgiveness and health connection. We offer a review of common ways to define forgiveness of others and self-forgiveness. Stress-and-coping theories of forgiveness of others and self-forgiveness are outlined. Both theories consider antecedents, correlates, and health outcomes of forgiveness of others and self-forgiveness and both offer a comprehensive and interpretive lens through which to view empirical research on associations between forgiveness of others and self-forgiveness with health outcomes. In reviewing 73 studies, we found seventy-five percent showed at least one connection between a dimension of forgiveness and a physical health outcome. We conclude by integrating and interpreting the research literature, identifying caveats and limitations, and offering a research agenda. Researchers and practitioners are encouraged to think broadly and model forgiveness-health relationships on established psychological and health theories and to execute theory-guided studies of the forgiveness and health connection.

Heilung ohne Wirkstoff: Wissenschaftliche Hintergründe und klinische Anwendungen des Placeboeffekts

Meißner, Karin (2025)

Gastvorlesung am Institut für Medizinische Psychologie, Medizinische Fakultät, LMU München.

Droplet-Based Measurements of DNA-Templated Nanoclusters—Towards Point-of-Care Applications

Kluitmann, Jonas; Di Fiore, Stefan; Nölke, Greta; Drese, Klaus Stefan (2025)

Biosensors 15 (7), 417.
DOI: 10.3390/bios15070417

Open Access

Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system

Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel...

Aging (Albany NY) 17 (7), 1784–1809.

Peer Reviewed

ABSTRACT

Aging is a complex process that significantly contributes to age-related diseases and poses significant challenges for effective interventions, with few holistic anti-aging approaches successfully reversing its signs. Heterochronic parabiosis studies illuminated the potential for rejuvenation through blood-borne factors, yet the specific drivers including underlying mechanisms remain largely unknown and until today insights have not been successfully translated to humans. In this study, we were able to recreate rejuvenation of the human skin via systemic factors using a microphysiological system including a 3D skin model and a 3D bone marrow model. Addition of young human serum in comparison to aged human serum resulted in an improvement of proliferation and a reduction of the biological age as measured by methylation-based age clocks in the skin tissue. Interestingly, this effect was only visible in the presence of bone marrow-derived cells. Further investigation of the bone marrow model revealed changes in the cell population in response to young versus aged human serum treatment. Using proteome analysis, we identified 55 potential systemic rejuvenating proteins produced by bone marrow-derived cells. For seven of these proteins, we were able to verify a rejuvenating effect on human skin cells using hallmarks of aging assays, supporting their role as systemic factors rejuvenating human skin tissue.

Privacy-preserving multicenter differential protein abundance analysis with FedProt

Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine...

Nature Computational Science 5 (8), 675–688.
DOI: 10.1038/s43588-025-00832-7

Peer Reviewed

Ultraschall-Check für die Hüftprothese

Lützelberger, Jan (2025)

Vortrag, Interdisziplinäres Wissenschaftliches Kolloquium an der Hochschule Coburg, Coburg, 2025.

Placebo Interventions to Modulate Appetite: Sex-Specific Psychobiological and Cognitive Responses

Symposium "Exploring the World of Appetite: How Placebo and Nocebo Impact Hunger, Food Preferences, and Weight Changes" (Żegleń M, Meissner K, Schmidt L), 5th International Conference of the Society for Interdisciplinary Placebo Studies (SIPS), Krakau, Polen.

Peer Reviewed

Experimental and computational identification of essential parameters governing biocide distribution in soil.

Kiefer, Nadine; Klein, Judith; Rohr, M; Noll, Matthias; Burkhart, Michael...

Environmental Toxicology and Chemistry 2025 (32), 2425-2440.
DOI: 10.1093/etojnl/vgaf156

Cardiological rehabilitation, prehabilitation, and cardiovascular prevention in adults with congenital heart defects: tasks and services of the German Pension Insurance-part 1: preventive cardiology and prehabilitation

Barth, J; Dewald, O; Ewert, Peter; Freiberger, Annika; Freilinger, Sebastian...

Cardiovasc Diagn Ther 15 (3), 684-695.
DOI: 10.21037/cdt-2024-691

Open Access Peer Reviewed

Cardiological rehabilitation, prehabilitation, and cardiovascular prevention in adults with congenital heart defects: tasks and services of the German Pension Insurance-part 2: cardiological rehabilitation

Barth, J; Dewald, O; Ewert, Peter; Freiberger, Annika; Freilinger, Sebastian...

Cardiovasc Diagn Ther 15 (3), 696-704.
DOI: 10.21037/cdt-2024-692

Open Access Peer Reviewed

Phased-Array basiertes Structural Health Monitoring zur Delaminationserkennung bei Mehrschichtsystemen

Backer, Alexander; Drese, Klaus Stefan (2025)

tm - Technisches Messen.
DOI: 10.1515/teme-2024-0111

Peer Reviewed

ABSTRACT

Zusammenfassung

Geführte Akustische Wellen (GAW) haben sich im Themengebiet des Structural Health Monitoring (SHM) etabliert. Neben ihren Vorteilen bei der Überwachung von Objekten und Detektion von Fehlstellen, gibt es jedoch auch einige Herausforderungen. Zu diesen zählt die dispersive Natur der häufig eingesetzten Lambwellen. Dispersion führt zu Signalverzerrung und reduziert dadurch die räumliche Auflösung und erschwert die Erkennung von schwach reflektierenden Fehlstellen. In diesem Beitrag wird der Einsatz eines Phased-Array-Systems zur Delaminationserkennung bei einem Mehrschichtsystem demonstriert, bei dem dispersive Lambwellen zum Einsatz kommen. Durch das Kompensieren der Dispersionseffekte kann die Sign Coherence Factor (SCF) Erweiterung des Total Focusing Method (TFM) Algorithmus eingesetzt und so auch schwach reflektierende Fehlstellen erkannt werden. Des Weiteren wird auf das Entstehen von Modenüberlagerungen bei Mehrschichtsystemen eingegangen, die bei der Auswahl der Arbeitsfrequenz und Sendesignallänge des Phased-Array-Systems berücksichtigt werden müssen.

Abstract

Guided Acoustic Waves (GAW) are well established in the field of Structural Health Monitoring (SHM). However, in addition to their advantages in monitoring objects and detecting defects, there are also several challenges. These include the dispersive nature of the commonly used Lamb waves. Dispersion leads to signal distortion that reduces spatial resolution and makes it difficult to detect weakly reflecting defects. This paper demonstrates the use of a phased array system for delamination detection in a multilayer system using dispersive Lamb waves. By compensating for the dispersion effects, the Sign Coherence Factor (SCF) extension of the Total Focusing Method (TFM) algorithm can be used to detect even weakly reflective defects. Furthermore, the occurrence of mode superposition in multilayer systems is discussed, which must be taken into account when selecting the operating frequency and transmit signal length of the phased array system.

Exploring the Role of Negative Expectations and Emotions in Primary Dysmenorrhea: Insights from a Case-Control Study

Thomann, Verena; Gomaa, Nadya; Stang, Marina; Funke, Susanne A.; Meißner, Karin (2025)

BMC Women's Health (25), 241.

Open Access Peer Reviewed

Traditional Chinese medicine for post-COVID: A retrospective cohort study

Kraft, Jana; Hardy, Anne; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina...

Medicine 104 (18), e42275.

Open Access Peer Reviewed

ABSTRACT

Post-COVID syndrome affects at least 10% of individuals recovering from COVID-19. Currently, there is no causal treatment. This retrospective cohort study aimed to evaluate the potential of traditional Chinese medicine (TCM) in treating post-COVID symptoms. TCM physicians in Germany and Austria completed online questionnaires to retrospectively record symptoms, treatment approaches, and outcomes for patients diagnosed with post-COVID. Nine physicians collected data from 79 patients (65% female, 47 ± 16 SD). The most common TCM treatments for post-COVID were acupuncture (n = 66; 85%), Chinese pharmacological therapy (n = 61; 77%), and Chinese dietary counseling (n = 32; 41%). After an average of 7 ± 4 TCM consultations, physicians rated global symptom improvement as 62% ± 29%. Significant alleviation from the start of TCM treatment was observed in major symptoms, such as fatigue (P < .001), impaired physical performance (P < .001), and exertional dyspnea (P < .001). TCM treatment was associated with significant improvements in post-COVID symptoms, warranting further evaluation through randomized controlled studies.

Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension

Mattias, Francescapaola; Tsoy, Olga; Hammer, Elke; Gress, Alexander; Simm, Stefan...

J. Am. Soc. Nephrol. 36 (9), 1702–1715.

Open Access Peer Reviewed

ABSTRACT

BACKGROUND: Alterations in pre-mRNA splicing are crucial to the pathophysiology of various diseases. However, the effects of alternative splicing of mRNA on podocytes in hypertensive nephropathy are still unknown. The Sys_CARE project aimed to identify alternative splicing events involved in the development and progression of glomerular hypertension. METHODS: Murine podocytes were exposed to mechanical stretch, after which proteins and mRNA were analyzed by proteomics, RNA sequencing and several bioinformatic alternative splicing tools. RESULTS: Using transcriptomic and proteomic analysis, we identified significant changes in gene expression and protein abundance due to mechanical stretch. RNA-Seq identified over 3,000 alternative spliced genes after mechanical stretch, including all types of alternative splicing events. Among these, 17 genes exhibited an alternative splicing event across four different splicing analysis tools. From this group, we focused on Myl6, a component of the myosin protein complex, and Shroom3, an actin-binding protein essential for podocyte function. We identified two Shroom3 isoforms with significant expression changes under mechanical stretch, which was validated by qRT-PCR and in situ hybridization. Additionally, we observed an expression switch of two Myl6 isoforms after mechanical stretch, accompanied by an alteration in the C-terminal amino acid sequence. CONCLUSIONS: A comprehensive RNA-Seq analysis of mechanically stretched podocytes identified novel potential podocyte-specific biomarkers and highlighted significant alternative splicing events, notably in the mRNA of Shroom3 and Myl6.

Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)

Hochschule Coburg

Friedrich-Streib-Str. 2
96450 Coburg

Support of publications
Dr. phil. Jakob Hanke
Forschungsreferent
T +49 9561 317 360
jakob.hanke[at]hs-coburg.de