Reliability of continuous vital sign monitoring in post-operative patients employing consumer-grade fitness trackers: A randomised pilot trial
Helmer, Philipp; Hottenrott, Sebastian; Wienböker, Kathrin; Pryss, Rüdiger; Drosos, Vasileios; Seitz, Anna Katharina; Röder, Daniel; Jovanoviç, Aleksandar; Kranke, Peter; Meybohm, Patrick; Winkler, Bernd E (2024)
Helmer, Philipp; Hottenrott, Sebastian; Wienböker, Kathrin; Pryss, Rüdiger...
eCollection 2024 Jan-Dec (10), 20552076241254026.
DOI: 10.1177/20552076241254026
Open Access Peer Reviewed
Psychotherapy with somatosensory stimulation as a complementary treatment for women with endometriosis-associated pain – a qualitative study
Limmer, A.; Weber, Annemarie; Olliges, Elisabeth; Kraft, Jana; Beissner, F.; Preibisch, C.; Meißner, Karin (2024)
Limmer, A.; Weber, Annemarie; Olliges, Elisabeth; Kraft, Jana; Beissner, F....
BMC Complementary Medicine and Therapies 24, 426 | 1-9.
DOI: 10.1186/s12906-024-04731-8
Open Access Peer Reviewed
Was ist dran am Placebo-Effekt?
Meißner, Karin (2024)
Interview in Ö1, Sendung Dimensionen, 23.12.2024.
Open Access
Satiety-enhancing placebo intervention decreases selective attention to food cues
Lanz, Marina; Hoffmann, Verena; Meißner, Karin (2024)
Frontiers in Psychiatry 15, 1472532 | 1-11.
DOI: 10.3389/fpsyt.2024.1472532
Open Access Peer Reviewed
Best-Practice-Beispiele der Evaluationsforschung in der kommunalen Gesundheitsförderung: das Projekt „Gesunde Südstadt"
John, Dennis; Kohls, Niko (2024)
(77), 8.
DOI: 10.17883/fet-schriften077
Open Access
Seit Inkrafttreten des Präventionsgesetzes (PrävG) im Jahr 2015 wurden bundesweit Projekte der gesetzlichen Krankenversicherungen (GKV) zur Gesundheitsförderung und Prävention (GfP) initiiert. Die Messung der Wirkung von GfP wurde im PrävG nicht explizit formuliert, mit der Folge, dass in den letzten 10 Jahren externe Evaluationsstudien nicht flächendeckend und systematisch in GKV-geförderten Projekten zur GfP eingesetzt wurden. Dennoch gibt es einige Beispiele von Evaluationsstudien, die Effekte von GKV-geförderten Projekten der GfP auf relevante Zielgruppen in verschiedenen Lebenswelten empirisch untersucht haben, vor allem in der kommunalen Gesundheitsförderung. Evaluation von Projekten der GfP in Kommunen wurden sowohl in Städten als auch im ländlichen Raum durchgeführt. Evaluationsforschung in GKV-geförderten Projekten der GfP ist auch 10 Jahre nach Inkrafttreten des Präventionsgesetzes kein wissenschaftlicher Selbstzweck. Evidenzbasierung und Wirkungsorientierung tragen - auch vor dem Hintergrund eines zunehmenden legitimatorischen (Kosten-)Drucks - zur Nachhaltigkeit von Projekten der GfP bei. Im folgenden Beitrag wird ein Best-Practice-Beispiel vorgestellt, mit dem Ziel aufzuzeigen, wie externe Begleitevaluationen in GKV-geförderten Projekten der kommunalen Gesundheits-förderung integriert werden können.
TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury
Hartmannsberger, Beate; Ben-Kraiem, Adel; Kramer, Sofia; Guidolin, Carolina; Kazerani, Ida; Doppler, Kathrin; Thomas, Dominique; Gurke, Robert; Sisignano, Marco; Kalelkar, Pranav; García, Andrés; Monje, Paula; Nusrat, Asma; Sammeth, Michael; Krug, Susanne; Sommer, Claudia; Rittner, Heike (2024)
Hartmannsberger, Beate; Ben-Kraiem, Adel; Kramer, Sofia; Guidolin, Carolina...
Acta Neuropathologica 149 (16), 1.
Open Access Peer Reviewed
Feels like home: A biobased and biodegradable plastic offers a novel habitat for diverse plant pathogenic fungi in temperate forest ecosystems
Nonthijun, Parada; Tanunchai, Benjawan; Schroeter , Simon Andreas; Wahdan, S. F. M.; Alves , G. E.; Hilke , Ines; Buscot, F.; Schulze, Ernst-Detlef ; Disayathanoowat, Terd; Purahong, W.; Noll, Matthias (2024)
Nonthijun, Parada; Tanunchai, Benjawan; Schroeter , Simon Andreas; Wahdan, S. F. M....
Microbial Ecology 2024 (87), 155.
DOI: 10.1007/s00248-024-02466-0.
Open Access Peer Reviewed
SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma
Somova, Maryna; Simm, Stefan; Ehrhardt, Jens; Schoon, Janosch; Burchardt, Martin; Pinto, Pedro (2024)
Somova, Maryna; Simm, Stefan; Ehrhardt, Jens; Schoon, Janosch; Burchardt, Martin...
Cells 13 (24), 2038.
DOI: 10.3390/cells13242038
Open Access Peer Reviewed
Renal cell carcinoma (RCC) is the most common form of kidney cancer, known for its immune evasion and resistance to chemotherapy. Evidence indicates that the SARS-CoV-2 virus may worsen outcomes for RCC patients, as well as patients with diminished renal function. Evidence suggests that the SARS-CoV-2 virus may exacerbate outcomes in RCC patients and those with impaired renal function. This study explored the unidirectional effects of RCC cells and the SARS-CoV-2 spike protein (S protein) on human renal proximal tubule epithelial cells (RPTECs) using a microphysiological approach. We co-cultured RCC cells (Caki-1) with RPTEC and exposed them to the SARS-CoV-2 S protein under dynamic 3D conditions. The impact on metabolic activity, gene expression, immune secretions, and S protein internalization was evaluated. The SARS-CoV-2 S protein was internalized by RPTEC but poorly interacted with RCC cells. RPTECs exposed to RCC cells and the S protein exhibited upregulated expression of genes involved in immunogenic pathways, particularly those related to antigen processing and presentation via the major histocompatibility complex I (MHCI). Additionally, increased TNF-α secretion suggested a pro-inflammatory response. Metabolic shifts toward glycolysis were observed in RCC co-culture, while the presence of the S protein led to minor changes. The presence of RCC cells amplified the immune-modulatory effects of the SARS-CoV-2 S protein on the renal epithelium, potentially exacerbating renal inflammation and fostering tumor-supportive conditions. These findings suggest that COVID-19 infections can impact renal function in the presence of kidney cancer.
The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights
Siegerist, Florian; Kliewe, Felix; Hammer, Elke; Schakau, Paul; Chi Soh, Joanne; Weber, Claudia; Lindenmeyer, Maja; Reichelt-Wurm, Simone; Drenic, Vedran; Chatziantoniou, Christos; Chadjichristos, Christos; Zhang, Yiying; Simm, Stefan; Banas, Miriam; Nauck, Matthias; Völker, Uwe; Endlich, Nicole (2024)
Siegerist, Florian; Kliewe, Felix; Hammer, Elke; Schakau, Paul; Chi Soh, Joanne...
iScience 27 (12), 111329.
DOI: 10.1016/j.isci.2024.111329
Open Access Peer Reviewed
The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized. The role of ILDR2 in podocytes, specialized epithelial cells in the kidney, is still unknown. We investigated the role of ILDR2 in glomeruli and its influence on blood filtration. Western blots, single-cell RNA sequencing (scRNA-seq), and superresolution microscopy showed a strong expression of ILDR2 in podocytes that colocalized with the podocyte-specific claudin CLDN5. Co-immunoprecipitation revealed that ILDR2 interacts with CLDN5. In glomerulopathies, induced by nephrotoxic serum and by desoxycorticosterone acetate (DOCA)-salt heminephrectomy, ILDR2 was strongly up-regulated. Furthermore, Ildr2 knockout mice exhibited glomerular hypertrophy and decreased podocyte density. However, they did not develop effacement of podocyte foot processes or proteinuria. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis of isolated glomeruli showed an increase in matrix proteins, such as fibronectin and collagens. This suggests a protective role of ILDR2 in glomerulopathies.
Stressfrei durch die Wechseljahre: Bewältigungsstrategien für ein gesundes und aktives Leben
Meißner, Karin (2024)
Vortrag auf dem Menopausenfachtag des Landratsamts Lichtenfels.
Selbstfürsorge im Alltag
Kohls, Niko (2024)
Krisen überstehen: Psychologe gibt Tipps, wie Sie unsichere Zeiten meistern
Kohls, Niko (2024)
Focus Online.
Überleben in VUCA- und BANI-Welten: Neue Anforderungen an Stressbewältigung
Kohls, Niko (2024)
Verhaltenstherapie & Psychosoziale Praxis 56 (3), 410–426.
Predictors of the Effectiveness of Immersive VR based Interventions for Stress Reduction: A Protocol for a Systematic Review with Meta-Analysis
Strauch, Hannah; Schuil, Isabel; Simm, Stefan; Kraft, Mirko; Meißner, Karin (2024)
Mind-Bull. Mind-Body Med. Res 3, 12-13.
Open Access Peer Reviewed
Stress-Reducing Effects of Forest Bathing in Immersive Virtual Reality: Protocol for a Randomized Controlled Trial
Schuil, Isabel; Kalamkar, Snehanjali; Grubert, Jens; Streuber, Stephan; Meißner, Karin (2024)
Schuil, Isabel; Kalamkar, Snehanjali; Grubert, Jens; Streuber, Stephan...
Mind-Bull. Mind-Body Med. Res 3, 16-17.
Open Access Peer Reviewed
XModNN: Explainable Modular Neural Network to Identify Clinical Parameters and Disease Biomarkers in Transcriptomic Datasets
Oldenburg, Jan; Wagner, Jonas; Troschke-Meurer, Sascha; Plietz, Jessica; Kaderali, Lars; Völzke, Henry; Nauck, Matthias; Homuth, Georg; Völker, Uwe; Simm, Stefan (2024)
Oldenburg, Jan; Wagner, Jonas; Troschke-Meurer, Sascha; Plietz, Jessica; Kaderali, Lars...
Biomolecules 14 (12), 1501.
DOI: 10.3390/biom14121501
Open Access Peer Reviewed
The Explainable Modular Neural Network (XModNN) enables the identification of biomarkers, facilitating the classification of diseases and clinical parameters in transcriptomic datasets. The modules within XModNN represent specific pathways or genes of a functional hierarchy. The incorporation of biological insights into the architectural design reduced the number of parameters. This is further reinforced by the weighted multi-loss progressive training, which enables successful classification with a reduced number of replicates. The combination of this workflow with layer-wise relevance propagation ensures a robust post hoc explanation of the individual module contribution. Two use cases were employed to predict sex and neuroblastoma cell states, demonstrating that XModNN, in contrast to standard statistical approaches, results in a reduced number of candidate biomarkers. Moreover, the architecture enables the training on a limited number of examples, attaining the same performance and robustness as support vector machine and random forests. The integrated pathway relevance analysis improves a standard gene set overrepresentation analysis, which relies solely on gene assignment. Two crucial genes and three pathways were identified for sex classification, while 26 genes and six pathways are highly important to discriminate adrenergic-mesenchymal cell states in neuroblastoma cancer.
Leichter leben mit Endometriose: Ganzheitliche Behandlungsansätze
Meißner, Karin (2024)
Vortrag am Landratsamt Kronach.
Comparative Methods for Demystifying Spatial Transcriptomics
Sammeth, Michael; Mudra, Susann; Bialdiga, Sina; Hartmannsberger, Beate; Kramer, Sofia; Rittner, Heike (2024)
Sammeth, Michael; Mudra, Susann; Bialdiga, Sina; Hartmannsberger, Beate; Kramer, Sofia...
Comparative Genomics 2024 (2802), 515-546.
DOI: 10.1007/978-1-0716-3838-5
Peer Reviewed
Interpretable Hierarchical Neural Networks for RNAseq Phenotyping
Jovanovic, Aleksandar; Sammeth, Michael (2024)
Peer Reviewed
4you - das Hochschulmagazin: Forschungsprojekte rund um die Ernährung
Meißner, Karin (2024)
TV Oberfranken.
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de