FNG: Publikationen

Stress reduction through taiji: a systematic review and meta‑analysis

Kraft, Jana; Waibl, Paula; Meißner, Karin (2024)

BMC Complementary Medicine and Therapies 24, 210 | 1-14.
DOI: 10.1186/s12906-024-04493-3

Open Access Peer Reviewed

Agent-based modeling to estimate the impact of lockdown scenarios and events on a pandemic exemplified on SARS-CoV-2

Nitzsche, Christian; Simm, Stefan (2024)

Scientific Reports 14 (1), 13391.
DOI: 10.1038/s41598-024-63795-1

Open Access Peer Reviewed

ABSTRACT

In actual pandemic situations like COVID-19, it is important to understand the influence of single mitigation measures as well as combinations to create most dynamic impact for lockdown scenarios. Therefore we created an agent-based model (ABM) to simulate the spread of SARS-CoV-2 in an abstract city model with several types of places and agents. In comparison to infection numbers in Germany our ABM could be shown to behave similarly during the first wave. In our model, we implemented the possibility to test the effectiveness of mitigation measures and lockdown scenarios on the course of the pandemic. In this context, we focused on parameters of local events as possible mitigation measures and ran simulations, including varying size, duration, frequency and the proportion of events. The majority of changes to single event parameters, with the exception of frequency, showed only a small influence on the overall course of the pandemic. By applying different lockdown scenarios in our simulations, we could observe drastic changes in the number of infections per day. Depending on the lockdown strategy, we even observed a delayed peak in infection numbers of the second wave. As an advantage of the developed ABM, it is possible to analyze the individual risk of single agents during the pandemic. In contrast to standard or adjusted ODEs, we observed a 21% (with masks) / 48% (without masks) increased risk for single reappearing participants on local events, with a linearly increasing risk based on the length of the events.

Author Correction: Integrating tumor and healthy epithelium in a micro-physiology multi-compartment approach to study renal cell carcinoma pathophysiology

Somova, Maryna; Simm, Stefan; Padmyastuti, Adventina; Ehrhardt, Jens; Schoon, Janosch...

Scientific Reports 14 (1), 14663.
DOI: 10.1038/s41598-024-64959-9

Open Access Peer Reviewed

Integrating Traditional Chinese Medicine and Psychotherapy in Women with Endometriosis: A Clinical Trial

Meißner, Karin (2024)

2024 Taiwan-German Joint Symposium on TCM health promotion, University & China Medical University Hospital, Taichung, Taiwan.

Nurturing Hope: Reproductive Outcomes with Sinosomatics Following Unsuccessful IVF Attempts

Pfeiffer, Antonia; Popovici, R. M.; Vogel, A.; von Hasselbach, Yumiko; Beissner, F....

Complementary Medicine Research.
DOI: 10.1159/000539408

Open Access Peer Reviewed

Explaining jet lag symptom dynamics by mathematical estimates of circadian phase post-flight

Aschl, Franz; Müller, Johannes ; Hammad, Grégory ; Oexle, Konrad ...

Conference "Society for Research on Biological Rhythms (SRBR) Biennial Meeting", San Juan, Puerto Rico, May 18-22, 2024.

Peer Reviewed

Lebensqualität und Schmerzen von Patienten mit symptomatischer CMD – eine Fragebogenerhebung

Pampel, M.; Herrmann, Sarah; Kohls, Niko; Meißner, Karin (2024)

Journal of Craniomandibular Function 16 (2), 133-144.

Peer Reviewed

Mehr Lebensfreude durch Resilienz und Achtsamkeit

Kohls, Niko (2024)

Gesundheitstag 2024 der Stadt Coburg.

‘Pathfinder-CHD Registry’ A prospective, comprehensive heart failure database of Adults with Congenital Heart Disease

Kaemmerer, Harald; Kohls, Niko; Freilinger, Sebastian (2024)

Poster Presentation 57th Annual Meeting of the Association for European Paediatric and Congenital Cardiology to be held in Porto, Portugal, between 8-11 May 2024..

Peer Reviewed

Kann Architektur krank machen? Gesundheit braucht Ästhetik

Kohls, Niko; Heinrich, Michael (2024)

Podcast Hochschule Coburg.

Kann Architektur krank machen? Gesundheit braucht Ästhetik

Heinrich, Michael; Kohls, Niko (2024)

Podcast Hochschule Coburg.

Gesundheitstag für Lehrkräfte

Kohls, Niko (2024)

Organisation.

Integrating tumor and healthy epithelium in a micro-physiology multi-compartment approach to study renal cell carcinoma pathophysiology

Somova, Maryna; Simm, Stefan; Padmyastuti, Adventina; Ehrhardt, Jens; Schoon, Janosch...

Scientific Reports 2024 / 14 (1), 9357.
DOI: 10.1038/s41598-024-60164-w

Open Access Peer Reviewed

ABSTRACT

The advent of micro-physiological systems (MPS) in biomedical research has enabled the introduction of more complex and relevant physiological into in vitro models. The recreation of complex morphological features in three-dimensional environments can recapitulate otherwise absent dynamic interactions in conventional models. In this study we developed an advanced in vitro Renal Cell Carcinoma (RCC) that mimics the interplay between healthy and malignant renal tissue. Based on the TissUse Humimic platform our model combines healthy renal proximal tubule epithelial cells (RPTEC) and RCC. Co-culturing reconstructed RPTEC tubules with RCC spheroids in a closed micro-perfused circuit resulted in significant phenotypical changes to the tubules. Expression of immune factors revealed that interleukin-8 (IL-8) and tumor necrosis factor-alfa (TNF-α) were upregulated in the non-malignant cells while neutrophil gelatinase-associated lipocalin (NGAL) was downregulated in both RCC and RPTEC. Metabolic analysis showed that RCC prompted a shift in the energy production of RPTEC tubules, inducing glycolysis, in a metabolic adaptation that likely supports RCC growth and immunogenicity. In contrast, RCC maintained stable metabolic activity, emphasizing their resilience to external factors. RNA-seq and biological process analysis of primary RTPTEC tubules demonstrated that the 3D tubular architecture and MPS conditions reverted cells to a predominant oxidative phosphorylate state, a departure from the glycolytic metabolism observed in 2D culture. This dynamic RCC co-culture model, approximates the physiology of healthy renal tubules to that of RCC, providing new insights into tumor-host interactions. Our approach can show that an RCC-MPS can expand the complexity and scope of pathophysiology and biomarker studies in kidney cancer research.

Mehr Lebensfreude durch Achtsamkeit und Resilienz

Kohls, Niko (2024)

Vortrag.

Forum 1.5 Bamberg-Coburg e.V. als zivilgesellschaftlicher Akteur im regionalen Raum für Transformation

Esslinger, Adelheid Susanne (2024)

15. Internationale NPO-Colloquium, Frankfurt a.M..

Peer Reviewed

Nachhaltigkeit an der Hochschule – ein whole instutution approach im Fallbeispiel

Esslinger, Adelheid Susanne; Tvrtkovic, Mario (2024)

15. Internationales NPO-Kolloquium, Frankfurt a.M..

Peer Reviewed

Zyxin is important for the stability and function of podocytes, especially during mechanical stretch

Kliewe, Felix; Siegerist, Florian; Hammer, Elke; Al-Hasani, Jaafar; Amling, Theodor...

Communications Biology 7 (1), 446.
DOI: 10.1038/s42003-024-06125-5

Open Access Peer Reviewed

ABSTRACT

Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in podocytes after mechanical stretch and relocalizes from focal adhesions to actin filaments. In zyxin knockout podocytes, we found that the loss of zyxin reduced the expression of vinculin and VASP as well as the expression of matrix proteins, such as fibronectin. This suggests that zyxin is a central player in the translation of mechanical forces in podocytes. In vivo, zyxin is highly up-regulated in patients suffering from diabetic nephropathy and in hypertensive DOCA-salt treated mice. Furthermore, zyxin loss in mice resulted in proteinuria and effacement of podocyte foot processes that was measured by super resolution microscopy. This highlights the essential role of zyxin for podocyte maintenance in vitro and in vivo, especially under mechanical stretch.

PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods.

Freilinger, Sebastian; Kohls, Niko; Kaemmerer, Harald (2024)

BMC Cardiovascular Disorders 24 (1), 181.
DOI: 10.1186/s12872-024-03833-y

Open Access Peer Reviewed

Enzymatic machinery of wood-inhabiting fungi that degrade temperate tree species

Kipping, Lydia; Jehmlich, N.; Moll, Julia; Noll, Matthias; Gossner, Martin M....

The ISME Journal 2024/18/1, wrae050.
DOI: 10.1093/ismejo/wrae050

Open Access Peer Reviewed

Die Entwicklung von individueller, gesellschaftlicher und planetarischer Resilienz - Achtsamkeit und ihre Bedeutsamkeit für Umwelt-, Klimaschutz und Nachhaltigkeit

Kohls, Niko; Pollan, Sandra; Heinrich, Michael (2024)

Erfolgsformel Achtsamkeit: Bewusst führen, nachhaltig gewinnen, Hrsg. Weifenbach, M., Litego Verlag 2024.

Peer Reviewed

Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)

Hochschule Coburg

Friedrich-Streib-Str. 2
96450 Coburg

Support of publications
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de