FNG: Publikationen

Fate of a biodegradable plastic in forest soil: Dominant tree species and forest types drive changes in microbial community assembly, influence the composition of plastisphere, and affect poly(butylene succinate co adipate) degradation

Tanunchai, Benjawan; Ji, Li; Schröder, O. (Hg.); Gawol, Susanne J.; Geissler, Andreas ...

Science of the Total Environment 873, 162230.
DOI: 10.1016/j.scitotenv.2023.162230

Peer Reviewed

The effects of pilates and open-label placebo on severe primary dysmenorrhea - a randomized controlled pilot study

Ort, Sandra; Waibl, Paula; Stang, Marina; Funke, Susanne A.; Dalkner, Nina...

Psychosomatic Medicine 85 (4), A28.
DOI: 10.1097/PSY.0000000000001202

Peer Reviewed

Usanovich and his all-In-one acid-base concept

Flechsig, Gerd-Uwe (2023)

Centenary Workshop on the Bifurcation of Acidity – Protonism vs. Electronism.

ABSTRACT

This contribution considers the little-known universal acid-base concept of Usanovich. It is quite interesting and useful to see how one can get from the proton-based and quantitative Brönsted-Lowry theory and the electron-based Lewis approach to a comprehensive and unified acid-base concept that includes exchange of all kinds of ions and even electrons. When the consideration of electron exchange touches even redox reactions, however, the Usanovich concept appears to most chemists as too far of a stretch. Publishing the original idea in a Soviet journal in Russian language did not help either in promoting it. Later articles were published in German, and even some English chemistry text books considered the contribution of Usanovich. These chapters, however, would disappear in later editions, and so, what remains today is the fascinating history of acid base concepts that can teach us on how competing ideas contribute to the progress of science in chemistry.

Die Entwicklung von Resilienz durch Achtsamkeit & Selbstregulation – Umgang mit Stress und Belastung in Krisenzeiten. Impuls-Vortag auf Einladung des Bayrischen Landesamts für Pflege, 23.2.2023.

Kohls, Niko (2023)

Umgang mit Stress und Belastung in Krisenzeiten. Impuls-Vortag auf Einladung des Bayrischen Landesamts für Pflege, 23.2.2023..

FungalTraits vs. FUNGuild: Comparison of ecological functional assignments of leaf- and needle-associated fungi across 12 temperate tree species

Tanunchai, Benjawan; Ji, Li; Wahdan, S. F. M.; Hossen, Shakhawat; Delelegn, Y....

Microbial Ecology 2023 / 85, 01973-2 | 411–428.
DOI: 10.1007/s00248-022-01973-2

Open Access Peer Reviewed

Ergebnisse der Mitgliederbefragungen der Ärztlichen und Offenen Schule der SMS im Frühjahr 2022

Waibl, Paula; Engelhardt, Ute; Nögel, Rainer; Hempen, Moritz; Meißner, Karin (2023)

Chinesische Medizin 38 (1), 30-39.
DOI: 10.1007/s00052-023-00074-8

Open Access Peer Reviewed

Vitamin D-Pillen: Segen oder Abzocke?

Meißner, Karin (2023)

SWR Doku (Interview).

Taste matters: Mapping expectancy-based appetitive placebo effects onto the brain

Khalid, Iraj; Rodrigues, Belina; Dreyfus, Hippolyte; Frileux, Solene; Meißner, Karin...

bioRxiv (Pre-print).
DOI: 10.1101/2023.02.14.527858

Open Access

Highly Sensitive Photoacoustic NO 2 Measurement System Based on an Optimized Ring-Shaped Resonant Cell

Fort, Ada; Mugnaini, Marco; Panzardi, Enza; Vignoli, Valerio; Dötzer, Florian...

IEEE Transactions on Instrumentation and Measurement 2023 (72), 1-10.
DOI: 10.1109/TIM.2023.3244222

Peer Reviewed

Was ist Achtsamkeit?

Kohls, Niko (2023)

ImpulsvortrIag im Rahmen der Creapolis-„Was-ist...“-Reihe der Hochschule Coburg, Creapolis Makerspace, 6.2.2023.

Selbst- und Fremdführung durch Achtsamkeit und die Ausbildung von Resilienz: Lebensqualität durch gesundheitsförderlichen Umgang mit Stress durch achtsamkeitsbasierte Verfahren

Kohls, Niko (2023)

Interdisziplinäres Therapeutentreffen Oberfranken: Praxis Dr. Michael Pampel, Coburg, 1.2.2023..

Placebo in der Schmerzmedizin

Meißner, Karin (2023)

Vortrag auf der externen Schmerzkonferenz mit Qualitätszirkel 2023, Schön Klinik Bad Staffelstein / alphaMED Bamberg.

Erstellung eines Fragebogens zur Evaluation der Lehre im Bereich der Naturheilverfahren (NHV) und Kommunikation im Medizinwesen (KIM)

Meißner, Karin (2023)

Teilnahme an Konsensuskonferenz, Fachbereich Integrative Medizin, Universitätsklinikum Ulm, Deutschland.

Alzheimer-Demenz – neue therapeutische Optionen?

Funke, Susanne A. (2023)

Lehrerfortbildung, Hochschule Coburg.

Co-infection of potential tick-borne pathogens of the order Rickettsiales and Borrelia burgdorferi s. l. and their link to season and area in Germany

Ernst (geb. Hoffmann), Angeline; Müller, T.; Fingerle, V.; Silaghi, C....

MDPI Microorganisms 11, 157.
DOI: 10.3390/microorganisms11010157

Open Access Peer Reviewed

Accuracy and Systematic Biases of Heart Rate Measurements by Consumer-Grade Fitness Trackers in Postoperative Patients: Prospective Clinical Trial.

Helmer, Philipp; Hottenrott, Sebastian; Rodemers, Philipp; Leppich, Robert...

Journal of Medical Internet Research 24(12), e42359.
DOI: 10.2196/42359

Open Access Peer Reviewed

ABSTRACT

Background: Over the recent years, technological advances of wrist-worn fitness trackers heralded a new era in the continuous monitoring of vital signs. So far, these devices have primarily been used for sports.

Objective: However, for using these technologies in health care, further validations of the measurement accuracy in hospitalized patients are essential but lacking to date.

Methods: We conducted a prospective validation study with 201 patients after moderate to major surgery in a controlled setting to benchmark the accuracy of heart rate measurements in 4 consumer-grade fitness trackers (Apple Watch 7, Garmin Fenix 6 Pro, Withings ScanWatch, and Fitbit Sense) against the clinical gold standard (electrocardiography).

Results: All devices exhibited high correlation (r≥0.95; P<.001) and concordance (rc≥0.94) coefficients, with a relative error as low as mean absolute percentage error <5% based on 1630 valid measurements. We identified confounders significantly biasing the measurement accuracy, although not at clinically relevant levels (mean absolute error<5 beats per minute).

Conclusions: Consumer-grade fitness trackers appear promising in hospitalized patients for monitoring heart rate.

Quality of life in adults with congenital heart disease with and without pulmonary hypertension: a comparative study

Freiberger, Annika; Busse, Amely; Ewert, Peter; Huntgeburth, Michael; Kaemmerer, Harald...

Cardiovascular Diagnosis and Therapy, 12(6), 758-766. , 758-766.
DOI: 10.21037/cdt-22-284

Peer Reviewed

Dark side of a bio-based and biodegradable plastic? Assessment of pathogenic microbes associated with poly(butylene succinate-co-adipate) under ambient and future climates using next-generation sequencing

Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Tongsuk, K.; Schädler , M....

Frontiers in Plant Science 13, 966363.
DOI: 10.3389/fpls.2022.966363

Open Access Peer Reviewed

tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions

Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin...

Cells 11 (24), 3970.
DOI: 10.3390/cells11243970

Open Access Peer Reviewed

ABSTRACT

The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions have been assigned to the nuclear transcripts, data on biological functions of the small cytosolic transcripts are sparse. We previously found NEAT1-/- and MALAT1-/- mice to display massive atherosclerosis and vascular inflammation. Here, employing selective targeted disruption of menRNA or mascRNA, we investigate the tRNA-like molecules as critical components of innate immunity. CRISPR-generated human ΔmascRNA and ΔmenRNA monocytes/macrophages display defective innate immune sensing, loss of cytokine control, imbalance of growth/angiogenic factor expression impacting upon angiogenesis, and altered cell-cell interaction systems. Antiviral response, foam cell formation/oxLDL uptake, and M1/M2 polarization are defective in ΔmascRNA/ΔmenRNA macrophages, defining first biological functions of menRNA and describing new functions of mascRNA. menRNA and mascRNA represent novel components of innate immunity arising from the noncoding genome. They appear as prototypes of a new class of noncoding RNAs distinct from others (miRNAs, siRNAs) by biosynthetic pathway and intracellular kinetics. Their NEAT1-MALAT1 region of origin appears as archetype of a functionally highly integrated RNA processing system.

Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin

Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio...

The Journal of Investigative Dermatology 142 (12), 3136–3145.e11.
DOI: 10.1016/j.jid.2022.06.023

Open Access Peer Reviewed

ABSTRACT

Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and adequately respond to external stressors. Macrophages are important gatekeepers of tissue homeostasis, and it has been reported that their number and phenotype change during aging in a site-specific manner. How aging affects human skin macrophages and what implications this has for the aging process in the tissue are still not fully understood. Using single-cell RNA-sequencing analysis, we show that there is at least a 50% increase of macrophages in human aged skin, which appear to have developed from monocytes and exhibit more proinflammatory M1-like characteristics. In contrast, the cell-intrinsic ability of aged monocytes to differentiate into M1 macrophages was reduced. Using coculture experiments with aged dermal fibroblasts, we show that it is the aged microenvironment that drives a more proinflammatory phenotype of macrophages in the skin. This proinflammatory M1-like phenotype in turn negatively influenced the expression of extracellular matrix proteins by fibroblasts, emphasizing the impact of the aged macrophages on the skin phenotype.

Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)

Hochschule Coburg

Friedrich-Streib-Str. 2
96450 Coburg

Support of publications
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de