CFD: Communication-efficient federated distillation via soft-label quantization and delta coding
Sattler, Felix; Marban, Arturo; Rischke, Roman; Samek, Wojciech (2022)
IEEE Transactions on Network Science and Engineering 9 (4), 2025-2038.
Open Access Peer Reviewed
Federated learning in dentistry: Chances and challenges
Rischke, Roman; Schneider, Lisa; Müller, Karsten; Samek, Wojciech; Schwendicke, Falk; Krois, Joachim (2022)
Rischke, Roman; Schneider, Lisa; Müller, Karsten; Samek, Wojciech; Schwendicke, Falk...
Journal of Dental Research 101 (11), 1269-1273.
Open Access Peer Reviewed
Mehr Lebensfreude durch Achtsamkeit und Resilienz
Kohls, Niko (2022)
Gelassener und stärker durch die richtige Balance. München: Südwest..
Forgiveness and Physical Health: A Review of Theory and Evidence
Toussaint, L.; Webb, J. R.; Hirsch, J. K.; Kohls, Niko; Offenbacher, M.; Dezutter, J.; Nguyen, Q. A.; Vallejo, M. (2022)
Toussaint, L.; Webb, J. R.; Hirsch, J. K.; Kohls, Niko; Offenbacher, M.; Dezutter, J....
In F. Sirois (Ed.), Palgrave Handbook of Positive Psychology and Health. .
Peer Reviewed
Resilienz und Achtsamkeit im Hörsaal – Entwicklung von Selbstregulationskompetenz und Bewusstseinsbildung an Hochschulen
Kohls, Niko (2022)
Didaktiknachrichten 07, S. 9 – 12., 9-12.
Tau Aggregation Inhibiting Peptides as Potential Therapeutics for Alzheimer Disease
Aillaud, Isabelle; Funke, Susanne A. (2022)
Cellular and Molecular Neurobiology 2022.
DOI: 10.1007/s10571-022-01230-7
Open Access Peer Reviewed
Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine; Geyer, Joachim; Simm, Stefan; Tzvetkov, Mladen (2022)
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine...
International Journal of Molecular Sciences 23 (9), 5100.
DOI: 10.3390/ijms23095100
Open Access Peer Reviewed
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing in six additional dog breeds. Next, dog OCT1 and OCT2 were stably overexpressed in HEK293 cells and the transport kinetics of five drugs were analyzed. We observed strong differences in the transport kinetics between dog and human orthologs. Dog OCT1 transported fenoterol with 12.9-fold higher capacity but 14.3-fold lower affinity (higher KM) than human OCT1. Human OCT1 transported ipratropium with 5.2-fold higher capacity but 8.4-fold lower affinity than dog OCT1. Compared to human OCT2, dog OCT2 showed 10-fold lower transport of fenoterol and butylscopolamine. In conclusion, the functional characterization of dog OCT1 and OCT2 reported here may have implications when using dogs as pre-clinical models as well as for drug therapy in dogs.
Emission of CO2 and CH4 From 13 Deadwood Tree Species Is Linked to Tree Species Identity and Management Intensity in Forest and Grassland Habitats
Kipping, Lydia; Gossner, Martin M.; Koschorreck, Matthias; Muszynski, Sarah; Maurer, Florian; Weisser, Wolfgang W.; Noll, Matthias (2022)
Kipping, Lydia; Gossner, Martin M.; Koschorreck, Matthias; Muszynski, Sarah...
Global Biogeochemical Cycles 2022 (36), 5.
DOI: 10.1029/2021GB007143
Open Access Peer Reviewed
Open-label Placebos (Journal club)
Meißner, Karin; Olliges, Elisabeth; Weimer, K.; Beissner, F. (2022)
Complementary Medicine Research 29 (2), 23-29.
DOI: 10.1159/000524073
Open Access
More than you can see: Unraveling the ecology and biodiversity of lichenized fungi associated with leaves and needles of 12 temperate tree species using high throughput sequencing
Tanunchai, Benjawan; Schroeter , Simon Andreas; Ji, Li; Wahdan, S. F. M.; Hossen, Shakhawat; Lehnert , A.-S.; Grünberg, H.; Gleixner, Gerd; Buscot, F.; Schulze, Ernst-Detlef ; Noll, Matthias; Purahong, W. (2022)
Tanunchai, Benjawan; Schroeter , Simon Andreas; Ji, Li; Wahdan, S. F. M....
Frontiers in Microbiology 13, 90753.
DOI: 10.3389/fmicb.2022.907531
Open Access Peer Reviewed
Interactions Between High Load of a Bio-based and Biodegradable Plastic and Nitrogen Fertilizer Affect Plant Biomass and Health: A Case Study with Fusarium solani and Mung Bean (Vigna radiata L.)
Scheid, Sarah-Maria ; Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Buscot , F.; Noll, Matthias; Purahong , W. (2022)
Scheid, Sarah-Maria ; Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Buscot , F....
Brief Communication.
DOI: 10.1007/s10924-022-02435-z
Open Access
Leptolyngbya sp. NIVA-CYA 255, a Promising Candidate for Poly(3-hydroxybutyrate) Production under Mixotrophic Deficiency Conditions
Kettner, Alexander; Noll, Matthias; Griehl, C. (2022)
MDPI Biomolecules 2022 (504), 12.
DOI: 10.3390/biom12040504
Open Access Peer Reviewed
Psychosomatic interventions for functional post-COVID syndromes. Open-label placebo and paced breathing as patient-tailored interventions
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva; Jarczok, Marc N.; Weimer, K. (2022)
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva...
Poster presentation A1634, 79th Annual Scientific Meeting of the American Psychosomatic Society (APS), March 23-26, 2022, Long Beach, California, US 84 (5), A1-A153.
DOI: 10.1097/PSY.0000000000001095
Peer Reviewed
Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela; Grundhoff, Adam; Wegwitz, Florian ; Kalkhof, Stefan; Hildebrand, Janosch (2022)
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela...
Cells 11 (6), 959.
DOI: 10.3390/cells11060959
Open Access Peer Reviewed
Cross-kingdom interactions and functional patterns of active microbiota matter in governing deadwood decay
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M.; Jonas, Malter; Buscot, F.; Noll, Matthias (2022)
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M....
Proceedings of the Royal Society Biological Sciences 2022, 20220130.
DOI: 10.1098/rspb.2022.0130
Open Access Peer Reviewed
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie; Müller-Kuller, Uta; Gutfreund, Niklas; Riegel, Kristina; Smits, Jos; Schleiff, Enrico; Rajalingam, Krishnaraj; Zhou, Huiqing; Simm, Stefan; Dötsch, Volker (2022)
Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie...
Cell Death & Disease 13 (3), 204.
DOI: 10.1038/s41419-022-04659-2
Open Access Peer Reviewed
Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore, not only detrimental for the individual but affect the entire species. In oocytes, the surveillance of the structural integrity of the DNA is maintained by the p53 family member TAp63α. The TAp63α protein is highly expressed in a closed and inactive state and gets activated to the open conformation upon the detection of DNA damage, in particular DNA double-strand breaks. To understand the cellular response to DNA damage that leads to the TAp63α triggered oocyte death we have investigated the RNA transcriptome of oocytes following irradiation at different time points. The analysis shows enhanced expression of pro-apoptotic and typical p53 target genes such as CDKn1a or Mdm2, concomitant with the activation of TAp63α. While DNA repair genes are not upregulated, inflammation-related genes become transcribed when apoptosis is initiated by activation of STAT transcription factors. Furthermore, comparison with the transcriptional profile of the ΔNp63α isoform from other studies shows only a minimal overlap, suggesting distinct regulatory programs of different p63 isoforms.
Auf dem Weg zu Energieeffizienter Künstlicher Intelligenz: Welche Energieeinsparpotentiale bieten KI-Anwendungen?
Babilon, Linda; Kratochwill, Lisa; Müller, Karsten; Rischke, Roman; Samek, Wojciech; Stabernack, Benno; Steinert, Fritjof (2022)
Babilon, Linda; Kratochwill, Lisa; Müller, Karsten; Rischke, Roman; Samek, Wojciech...
Deutsche-Energie-Agentur (Hrsg.).
Open Access
A novel D-amino acid peptide with therapeutic potential, designated ISAD1, inhibits aggregation of disease relevant pro-aggregant mutant Tau and prevents Tau toxicity in vitro
Aillaud, Isabelle; Kaniyappan, S.; Chandupatla, R.R.; Ramirez, L.-M.; Alkhashrom, Sewar ; Eichler, Jutta; Horn, A. H. C.; Zweckstetter , M.; Mandelkow, E.; Sticht, H.; Funke, Susanne A. (2022)
Aillaud, Isabelle; Kaniyappan, S.; Chandupatla, R.R.; Ramirez, L.-M....
Alzheimer's Research & Therapy 14, 15.
DOI: 10.1186/s13195-022-00959-z
Open Access Peer Reviewed
Nitrogen fixing bacteria facilitate microbial biodegradation of a bio-based and biodegradable plastic in soils under ambient and future climatic conditions
Tanunchai, Benjawan; Kalkhof, Stefan; Guliyev , V.; Wahdan, S. F. M.; Krstic, Dennis; Schädler , M.; Geissler, Andreas ; Buscot, F.; Blagodatskaya , E.; Noll, Matthias; Purahong, W. (2022)
Tanunchai, Benjawan; Kalkhof, Stefan; Guliyev , V.; Wahdan, S. F. M.; Krstic, Dennis...
Environmental Science: Processes & Impacts Royal Society of Chemistry 2022 / 24, d1em00426c | 233-241.
DOI: 10.1039/D1EM00426C
Peer Reviewed
Herausforderungen anders begegnen
Kohls, Niko (2022)
Moment by Moment 1, S.64 - 67.
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de