Erstellung eines Fragebogens zur Evaluation der Lehre im Bereich der Naturheilverfahren (NHV) und Kommunikation im Medizinwesen (KIM)
Meißner, Karin (2023)
Teilnahme an Konsensuskonferenz, Fachbereich Integrative Medizin, Universitätsklinikum Ulm, Deutschland.
Alzheimer-Demenz – neue therapeutische Optionen?
Funke, Susanne A. (2023)
Lehrerfortbildung, Hochschule Coburg.
Co-infection of potential tick-borne pathogens of the order Rickettsiales and Borrelia burgdorferi s. l. and their link to season and area in Germany
Ernst (geb. Hoffmann), Angeline; Müller, T.; Fingerle, V.; Silaghi, C.; Noll, Matthias (2023)
Ernst (geb. Hoffmann), Angeline; Müller, T.; Fingerle, V.; Silaghi, C....
MDPI Microorganisms 11, 157.
DOI: 10.3390/microorganisms11010157
Open Access Peer Reviewed
Accuracy and Systematic Biases of Heart Rate Measurements by Consumer-Grade Fitness Trackers in Postoperative Patients: Prospective Clinical Trial.
Helmer, Philipp; Hottenrott, Sebastian; Rodemers, Philipp; Leppich, Robert; Helwich, Maja; Pryss, Rüdiger; Kranke, Peter; Meybohm, Patrick; Winkler, Bernd E; Sammeth, Michael (2022)
Helmer, Philipp; Hottenrott, Sebastian; Rodemers, Philipp; Leppich, Robert...
Journal of Medical Internet Research 24(12), e42359.
DOI: 10.2196/42359
Open Access Peer Reviewed
Background: Over the recent years, technological advances of wrist-worn fitness trackers heralded a new era in the continuous monitoring of vital signs. So far, these devices have primarily been used for sports.
Objective: However, for using these technologies in health care, further validations of the measurement accuracy in hospitalized patients are essential but lacking to date.
Methods: We conducted a prospective validation study with 201 patients after moderate to major surgery in a controlled setting to benchmark the accuracy of heart rate measurements in 4 consumer-grade fitness trackers (Apple Watch 7, Garmin Fenix 6 Pro, Withings ScanWatch, and Fitbit Sense) against the clinical gold standard (electrocardiography).
Results: All devices exhibited high correlation (r≥0.95; P<.001) and concordance (rc≥0.94) coefficients, with a relative error as low as mean absolute percentage error <5% based on 1630 valid measurements. We identified confounders significantly biasing the measurement accuracy, although not at clinically relevant levels (mean absolute error<5 beats per minute).
Conclusions: Consumer-grade fitness trackers appear promising in hospitalized patients for monitoring heart rate.
Quality of life in adults with congenital heart disease with and without pulmonary hypertension: a comparative study
Freiberger, Annika; Busse, Amely; Ewert, Peter; Huntgeburth, Michael; Kaemmerer, Harald; Kohls, Niko; Nagdyman, Nicole; Richter, Cristina; Röhrich, Christina; Von Scheidt, Fabian; Weyand, Michael; Freilinger, Sebastian; Andonian, Caroline (2022)
Freiberger, Annika; Busse, Amely; Ewert, Peter; Huntgeburth, Michael; Kaemmerer, Harald...
Cardiovascular Diagnosis and Therapy, 12(6), 758-766. , 758-766.
DOI: 10.21037/cdt-22-284
Peer Reviewed
Dark side of a bio-based and biodegradable plastic? Assessment of pathogenic microbes associated with poly(butylene succinate-co-adipate) under ambient and future climates using next-generation sequencing
Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Tongsuk, K.; Schädler , M.; Noll, Matthias; Purahong, W. (2022)
Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Tongsuk, K.; Schädler , M....
Frontiers in Plant Science 13, 966363.
DOI: 10.3389/fpls.2022.966363
Open Access Peer Reviewed
tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions
Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin; Mochmann, Liliana; Rad, Pegah; Weiss, Stefan; Simm, Stefan; Zeller, Tanja; Voelzke, Henry; Hoffmann, Wolfgang; Völker, Uwe; Felix, Stefan; Dörr, Marcus; Beling, Antje; Skurk, Carsten; Leistner, David-Manuel; Rauch, Bernhard; Hirose, Tetsuro; Heidecker, Bettina; Klingel, Karin; Nakagawa, Shinichi; Poller, Wolfram; Swirski, Filip; Haghikia, Arash; Poller, Wolfgang (2022)
Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin...
Cells 11 (24), 3970.
DOI: 10.3390/cells11243970
Open Access Peer Reviewed
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions have been assigned to the nuclear transcripts, data on biological functions of the small cytosolic transcripts are sparse. We previously found NEAT1-/- and MALAT1-/- mice to display massive atherosclerosis and vascular inflammation. Here, employing selective targeted disruption of menRNA or mascRNA, we investigate the tRNA-like molecules as critical components of innate immunity. CRISPR-generated human ΔmascRNA and ΔmenRNA monocytes/macrophages display defective innate immune sensing, loss of cytokine control, imbalance of growth/angiogenic factor expression impacting upon angiogenesis, and altered cell-cell interaction systems. Antiviral response, foam cell formation/oxLDL uptake, and M1/M2 polarization are defective in ΔmascRNA/ΔmenRNA macrophages, defining first biological functions of menRNA and describing new functions of mascRNA. menRNA and mascRNA represent novel components of innate immunity arising from the noncoding genome. They appear as prototypes of a new class of noncoding RNAs distinct from others (miRNAs, siRNAs) by biosynthetic pathway and intracellular kinetics. Their NEAT1-MALAT1 region of origin appears as archetype of a functionally highly integrated RNA processing system.
Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio; Bosch, Thomas; Wenck, Horst; Winnefeld, Marc; Grönniger, Elke; Simm, Stefan; Siracusa, Annette (2022)
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio...
The Journal of Investigative Dermatology 142 (12), 3136–3145.e11.
DOI: 10.1016/j.jid.2022.06.023
Open Access Peer Reviewed
Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and adequately respond to external stressors. Macrophages are important gatekeepers of tissue homeostasis, and it has been reported that their number and phenotype change during aging in a site-specific manner. How aging affects human skin macrophages and what implications this has for the aging process in the tissue are still not fully understood. Using single-cell RNA-sequencing analysis, we show that there is at least a 50% increase of macrophages in human aged skin, which appear to have developed from monocytes and exhibit more proinflammatory M1-like characteristics. In contrast, the cell-intrinsic ability of aged monocytes to differentiate into M1 macrophages was reduced. Using coculture experiments with aged dermal fibroblasts, we show that it is the aged microenvironment that drives a more proinflammatory phenotype of macrophages in the skin. This proinflammatory M1-like phenotype in turn negatively influenced the expression of extracellular matrix proteins by fibroblasts, emphasizing the impact of the aged macrophages on the skin phenotype.
Unspezifische Effekte von Operationen – Erkenntnisse aus der Placeboforschung
Meißner, Karin (2022)
Eingeladener Vortrag, Gründungsveranstaltung für das REGIOMED Zentrum für Wirbelsäulenmedizin, Regiomed Klinikum Lichtenfels .
Deep omics profiling of diabetic bone regeneration – Dysregulated molecular mechanisms and implications for personalized PCL-scaffold design
Kalkhof, Stefan (2022)
e:Med Meeting 2022 on Systems Medicine November 28-30, 2022 Heidelberg, DKFZ Communication Center.
Links among microbial communities, soil properties, and functions: Are fungi the sole players in the decomposition of bio-based and biodegradable plastic?
Guliyev , V.; Tanunchai, Benjawan; Noll, Matthias; Buscot, F.; Purahong, W.; Blagodatskaya , E. (2022)
Guliyev , V.; Tanunchai, Benjawan; Noll, Matthias; Buscot, F.; Purahong, W....
MDPI Polymers 14, 2801.
DOI: 10.3390/polym14142801
Open Access Peer Reviewed
Creditions in prevention and treatment: lessons learned from two empirical studies
Meißner, Karin (2022)
Vortrag auf der internationalen Tagung "The structure of creditions - methods, methodology, and assessment", Graz, Österreich.
Drivers of deadwood decay of 13 temperate tree species are similar between forest and grassland habitats
Kipping, Lydia; Maurer, Florian; Gossner, Martin M.; Muszynski, Sarah; Kahl, Tiemo; Kellner, H.; Weisser, Wolfgang W.; Jehmlich, N.; Noll, Matthias (2022)
Kipping, Lydia; Maurer, Florian; Gossner, Martin M.; Muszynski, Sarah; Kahl, Tiemo...
Frontiers in Forest & Global Change 5, 1020737.
DOI: 10.3389/ffgc.2022.1020737
Peer Reviewed
A systematic review to evaluate the stress relieving potential of qigong, taiji and acupressure
Meißner, Karin (2022)
Oral presentation, 2022 Xing-lin International Week of Chengdu University of Traditional Chinese Medicine (CDUTCM).
Selection of Listeria monocytogenes InlA-Binding Peptides Using Phage Display—Novel Compounds for Diagnostic Applications?
Kenzel, Julia; Brüggemann, Dagmar Adeline; Funke, Susanne A. (2022)
Applied Microbiology 2022 (4), 2 | 921-933.
DOI: 10.3390/applmicrobiol2040070
Open Access
Wie können IVF-Behandlungen weniger belastend gestaltet werden? Eine qualitative Studie zu den Erwartungen, Erfahrungen und Belastungen von Frauen mit wiederholt erfolglosen IVF-Behandlungen sollte Ansatzpunkte für Verbesserungen aufzeigen
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie; Olliges, Elisabeth; Kraft, Jana; Popovici, R. M.; Meißner, Karin (2022)
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie...
Frauenarzt - Offizielles Organ des Berufsverbands der Frauenärzte e.V. (BVF) sowie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. (DGGG) 63 (11), 722 – 726.
Mehr Lebensfreude durch Achtsamkeit und Resilienz
Kohls, Niko (2022)
Online-Keynote Veranstaltungsreihe „7 Lektionen zum Glück in der Medizin - Resilienz, Sinnhaftigkeit und Gesundheit für Mitarbeiter*innen im Gesundheitswesen“ des Philosophicum Herbipolense der Universität Würzburg, 27.10.2022. .
Resilience, Education and Architecture. Online,Presentation SHRINES OF WISDOM Conference.
Kohls, Niko (2022)
The Sacralization of Knowledge – A Core Dynamics of the Western Paradigm of Progress and its Architectural Expression within the College Topos, Jesus College, University of Cambridge, 16. Oktober 2022..
TCM combined with psychotherapy (sinosomatics) restores the cumulative birth rate of infertile women with poor prognosis to a normal level
Meißner, Karin (2022)
Oral presentation, 35th ICMART World Medical Acupuncture Congress, Bologna, Italy.
Entwicklung eines webbasierten Programms zur Risikoreduktion einer postpartalen Depression durch die Stärkung von salutogenetischen Protektivfaktoren
Kuhn, Maria; Kohls, Niko; Hinterberger, T. (2022)
Geburtshilfe Frauenheilkd, 82(10), 194.
Peer Reviewed
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de