Publikationen HS Coburg

Refugees and Art: Tailor-Made Integrative Art Projects by Identifying Citizen Target Groups

Schwarz , Nicole; Gross, Hellen; Cramer von Clausbruch , Stefanie; Hary , Katharina ...

25 (2), 16-33.

Peer Reviewed

A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS-Like Zebrafish Model

Schindler, Maximilian; Siegerist, Florian; Lange, Tim; Simm, Stefan; Bach, Sophia-Marie...

Journal of the American Society of Nephrology: JASN 34 (12), 1977–1990.
DOI: 10.1681/ASN.0000000000000235

Open Access Peer Reviewed

ABSTRACT

BACKGROUND: FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss of filtration barrier function and the development of sclerotic lesions. Therapies to treat FSGS are limited, and podocyte-specific drugs are unavailable. To address the need for treatments to delay or stop FSGS progression, researchers are exploring the repurposing of drugs that have been approved by the US Food and Drug Administration (FDA) for other purposes. METHODS: To identify drugs with potential to treat FSGS, we used a specific zebrafish screening strain to combine a high-content screening (HCS) approach with an in vivo model. This zebrafish screening strain expresses nitroreductase and the red fluorescent protein mCherry exclusively in podocytes (providing an indicator for podocyte depletion), as well as a circulating 78 kDa vitamin D-binding enhanced green fluorescent protein fusion protein (as a readout for proteinuria). To produce FSGS-like lesions in the zebrafish, we added 80 µ M metronidazole into the fish water. We used a specific screening microscope in conjunction with advanced image analysis methods to screen a library of 138 drugs and compounds (including some FDA-approved drugs) for podocyte-protective effects. Promising candidates were validated to be suitable for translational studies. RESULTS: After establishing this novel in vivo HCS assay, we identified seven drugs or compounds that were protective in our FSGS-like model. Validation experiments confirmed that the FDA-approved drug belinostat was protective against larval FSGS. Similar pan-histone deacetylase inhibitors also showed potential to reproduce this effect. CONCLUSIONS: Using an FSGS-like zebrafish model, we developed a novel in vivo HCS assay that identified belinostat and related pan-histone deacetylase inhibitors as potential candidates for treating FSGS.

Evaluation of crowdsourced mortality prediction models as a framework for assessing artificial intelligence in medicine

Bergquist, Timothy; Schaffter, Thomas; Yan, Yao; Yu, Thomas; Prosser, Justin...

Journal of the American Medical Informatics Association: JAMIA 31 (1), 35–44.
DOI: 10.1093/jamia/ocad159

Open Access Peer Reviewed

ABSTRACT

OBJECTIVE: Applications of machine learning in healthcare are of high interest and have the potential to improve patient care. Yet, the real-world accuracy of these models in clinical practice and on different patient subpopulations remains unclear. To address these important questions, we hosted a community challenge to evaluate methods that predict healthcare outcomes. We focused on the prediction of all-cause mortality as the community challenge question. MATERIALS AND METHODS: Using a Model-to-Data framework, 345 registered participants, coalescing into 25 independent teams, spread over 3 continents and 10 countries, generated 25 accurate models all trained on a dataset of over 1.1 million patients and evaluated on patients prospectively collected over a 1-year observation of a large health system. RESULTS: The top performing team achieved a final area under the receiver operator curve of 0.947 (95% CI, 0.942-0.951) and an area under the precision-recall curve of 0.487 (95% CI, 0.458-0.499) on a prospectively collected patient cohort. DISCUSSION: Post hoc analysis after the challenge revealed that models differ in accuracy on subpopulations, delineated by race or gender, even when they are trained on the same data. CONCLUSION: This is the largest community challenge focused on the evaluation of state-of-the-art machine learning methods in a healthcare system performed to date, revealing both opportunities and pitfalls of clinical AI.

Cuticular microbiome composition of Osmia bicornis is different to Apis mellifera honeybees

Thamm, M.; Reiß, Fabienne; Sohl, Leon; Gabel, M.; Noll, Matthias; Scheiner, Ricarda (2023)

MDPI microorganisms 11, 2780.
DOI: 10.3390/microorganisms11112780

Open Access Peer Reviewed

Who the Freedom? – When Design meets Theatre

Weinmann, Natalie; Prent, Lilian (2023)

DOI: 10.21606/drslxd.2024.092

Open Access Peer Reviewed

"Wie müssen sich Hochschulen, Studiengänge und Lehrpersonen ändern, damit ein interdisziplinäres Studium umgesetzt werden kann?"

Holtorf, Christian (2023)

Ringvorlesung "Interdisziplinarität in Studium und Beruf", Hochschule Konstanz..

Open Access

Fachgespräch: Selbst- und Fremdführung durch Achtsamkeit und die Ausbildung von Resilienz. Online-Workshop für das Bayrische Landesamt für Pflege, Ansbach, 22.11.2023

Kohls, Niko (2023)

Achtsamkeit und Nachhaltigkeit: Eine wissenschaftliche Perspektive. Vortag im Rahmen der Climate School, Hochschule Coburg.

Kohls, Niko (2023)

Wärmepumpen im Wohngebäude-Bestand – Technologie, Anwendung, Förderung

Schaub, Michael (2023)

Vortragsreihe des Klima- und Umweltbeirats der Gemeinde Dörfles-Esbach.

Achtsamkeit und Resilienz: gesund und erfüllt im Lehrerberuf – geht das? Keynote 15. Lehrergesundheitstag Gesunderhaltung im Lehrerberuf – analog und digital, Hochschule Hof, 16.11.2023.

Kohls, Niko (2023)

Postgraduale Weiterbildung in Sozialtherapie - Eine Bedarfsanalyse aus den Perspektiven von Studierenden und Fachkräften

Deloie, Dario; Kröger, Christine (2023)

Soziale Arbeit - Zeitschrift für soziale und sozialverwandte Gebiete 72. Jahrgang (11), 414-421.

Peer Reviewed

GEG-konforme Beheizung von Wohngebäuden – eine technologische Einordnung

Schaub, Michael (2023)

Themenabend VDI-Bezirksgruppe Coburg.
DOI: 10.13140/RG.2.2.22273.63849

Open Access

Sinn & Kohärenz: Die Psychologie als Lehre von Erleben und Verhalten zwischen Theorie und Empirie.

Kohls, Niko (2023)

Vision Zukunftstechnologie trifft Gastro

Zagel, Christian (2023)

DEHOGA Bayern.

Automatisierte Shuttles im ÖPNV: Kooperationen bei Betrieb und Organisation

Wilde, Mathias; Riedelbauch, Lukas (2023)

Nahverkehrs-praxis - Fachzeitschrift für moderne Mobilität (11/12), 20-23.

Control in Hybrid Chatbots

Rüdel, Thomas; Leidner, Jochen L. (2023)

Technical Report, ArXiv Pre-Print Server.
DOI: 10.48550/arXiv.2311.11701

Open Access

Wärmewende: Von Mehrfamilienhäusern, Wärmepumpen und Extremwetter‐Ereignissen

Schaub, Michael (2023)

Transforming Economies.

Open Access

Placebo responses and effects: Processes, potential, and ethical considerations in clinical care

Kohls, Niko; Leyva, Monica A.; Giordano, James (2023)

Placebo Effects Through the Lens of Translational Research 2023, 251 - 266.
DOI: 10.1093/med/9780197645444.003.0019

Open Access Peer Reviewed

Subjektivität und Objektivität im Kunsturteil

Heinrich, Michael (2023)

Vortrag und Diskussion, Schönheit im Wandel der Zeiten, Vorlesungsreihe, Lehrstuhl Philosophie II, Universität Bamberg, 2023.

Analytical and Numerical Investigations on the Stator Guide Vanes for Low-Pressure Axial Fans

Fritsche, Manuel; Epple, Philipp; Delgado , Antonio (2023)

ASME 2023 International Mechanical Engineering Congress and Exposition (IMECE2023) New Orleans, Louisiana, USA October 29–November 2, 2023..

Peer Reviewed

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Hochschule Coburg

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Support of publications

Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de