Leptolyngbya sp. NIVA-CYA 255, a Promising Candidate for Poly(3-hydroxybutyrate) Production under Mixotrophic Deficiency Conditions
Kettner, Alexander; Noll, Matthias; Griehl, C. (2022)
MDPI Biomolecules 2022 (504), 12.
DOI: 10.3390/biom12040504
Open Access Peer Reviewed
Psychosomatic interventions for functional post-COVID syndromes. Open-label placebo and paced breathing as patient-tailored interventions
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva; Jarczok, Marc N.; Weimer, K. (2022)
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva...
Poster presentation A1634, 79th Annual Scientific Meeting of the American Psychosomatic Society (APS), March 23-26, 2022, Long Beach, California, US 84 (5), A1-A153.
DOI: 10.1097/PSY.0000000000001095
Peer Reviewed
Podcast Inside Hochschule
Arbeiter, Georg (2022)
Podcast Radio Eins.
Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela; Grundhoff, Adam; Wegwitz, Florian ; Kalkhof, Stefan; Hildebrand, Janosch (2022)
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela...
Cells 11 (6), 959.
DOI: 10.3390/cells11060959
Open Access Peer Reviewed
Cross-kingdom interactions and functional patterns of active microbiota matter in governing deadwood decay
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M.; Jonas, Malter; Buscot, F.; Noll, Matthias (2022)
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M....
Proceedings of the Royal Society Biological Sciences 2022, 20220130.
DOI: 10.1098/rspb.2022.0130
Open Access Peer Reviewed
Von der „Lebensstilschluderei“ über die Gesundheitskompetenz zur agilen und resilienten Organisation Online-Keynote „Asset Gesundheit: Die unternehmerischen Vorteile. Die eigentliche Idee von BGM und warum es sich rechnet.
Kohls, Niko (2022)
Unternehmerforum Ruhr, Keynote, Online-Event.
Fahrerlose Shuttles im öffentlichen Personennahverkehr: Akzeptanz und Einstellung in der Bevölkerung
Wilde, Mathias; Rebhan , Jakob (2022)
Standort - Zeitschrift für Angewandte Geographie 46 (1), 2-8.
DOI: 10.1007/s00548-021-00746-2
Open Access Peer Reviewed
Resilienz, Schattenachtsamkeit und Spiritualität - Gedanken zur Dialektik von Bewusstseinskultivierung in Krisenzeiten
Kohls, Niko (2022)
Report Psychologie 47 (3), 6-10.
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie; Müller-Kuller, Uta; Gutfreund, Niklas; Riegel, Kristina; Smits, Jos; Schleiff, Enrico; Rajalingam, Krishnaraj; Zhou, Huiqing; Simm, Stefan; Dötsch, Volker (2022)
Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie...
Cell Death & Disease 13 (3), 204.
DOI: 10.1038/s41419-022-04659-2
Open Access Peer Reviewed
Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore, not only detrimental for the individual but affect the entire species. In oocytes, the surveillance of the structural integrity of the DNA is maintained by the p53 family member TAp63α. The TAp63α protein is highly expressed in a closed and inactive state and gets activated to the open conformation upon the detection of DNA damage, in particular DNA double-strand breaks. To understand the cellular response to DNA damage that leads to the TAp63α triggered oocyte death we have investigated the RNA transcriptome of oocytes following irradiation at different time points. The analysis shows enhanced expression of pro-apoptotic and typical p53 target genes such as CDKn1a or Mdm2, concomitant with the activation of TAp63α. While DNA repair genes are not upregulated, inflammation-related genes become transcribed when apoptosis is initiated by activation of STAT transcription factors. Furthermore, comparison with the transcriptional profile of the ΔNp63α isoform from other studies shows only a minimal overlap, suggesting distinct regulatory programs of different p63 isoforms.
Diversität und Teilhabe in Kunst und Kultur
Gross, Hellen (2022)
Kulturkonferenz des Landes Nordrhein-Westfalen 2022, 22. Februar 2022, virtuell .
Erweiterung von Gefahren- und Risikoanalysen der Funktionalen Sicherheit um Aspekte der Produktsicherheit nach ISO 12100
Emig , Moritz ; Metz, Pierre; Reißing, Ralf (2022)
Software Engineering 2022 Workshops, 2022, 82-93.
DOI: 10.18420/se2022-ws-11
Open Access Peer Reviewed
Aerodynamic Performance Analysis Of Winglets Of Modern Sailplanes
Kästner , J.; Epple, Philipp; Steppert, Michael (2022)
ASME 2021 International Mechanical Engineering Congress and Exposition IMECE2021
November 1–5, 2021
Virtual, Online 10.
DOI: 10.1115/IMECE2021-69672
Peer Reviewed
In this work the aerodynamic performance of winglets of modern sailplanes were investigated. First isolated wings with winglets were designed and investigated and compared to the wings without winglets, showing the fundamental working principle and effectiveness of winglets. Then a complete sailplane was designed with an integrated inviscid flow method with XFLR5 [1] combined with Navier-Stokes CFD with Siemens PLM STAR CCM+ computations. In such a way a modern sailplane was designed for operation with winglets. Using this modern sailplane design the impact of winglets on sailplanes was investigated in detail. This modern sailplane was simulated with CFD in the configurations without winglets and with two modern advanced winglets and their aerodynamic characteristics and performance were investigated and compared. All aerodynamic results are analyzed and shown in detail.
Wege zum Erfolg: Hundert Jahre Schaubilder von Interdisziplinarität
Holtorf, Christian (2022)
Vortrag am Fakultätszentrum für transdisziplinäre historischkulturwissenschaftliche Studien, Universität Wien.
A novel D-amino acid peptide with therapeutic potential, designated ISAD1, inhibits aggregation of disease relevant pro-aggregant mutant Tau and prevents Tau toxicity in vitro
Aillaud, Isabelle; Kaniyappan, S.; Chandupatla, R.R.; Ramirez, L.-M.; Alkhashrom, Sewar ; Eichler, Jutta; Horn, A. H. C.; Zweckstetter , M.; Mandelkow, E.; Sticht, H.; Funke, Susanne A. (2022)
Aillaud, Isabelle; Kaniyappan, S.; Chandupatla, R.R.; Ramirez, L.-M....
Alzheimer's Research & Therapy 14, 15.
DOI: 10.1186/s13195-022-00959-z
Open Access Peer Reviewed
Unternehmensgesundheit JETZT!
Kohls, Niko (2022)
Online-Keynote am Neujahrsempfang der Münchner Assekuranz.
Was ist Inklusion?
Lohrenscheit , Claudia (2022)
Vortrag im Rahmen der Reihe Creapolis am 10.1.2022 (Online via ZOOM).
Herausforderungen anders begegnen
Kohls, Niko (2022)
Moment by Moment 1, S.64 - 67.
New Work im New Office - Der Wandel der Arbeitswelt und dessen Auswirkungen auf den Büroalltag
Donhauser, A.; Phillips, Mark ; Vogt , Jennifer (2022)
Das menschliche Büro- The human(e) office 2022, 77-95.
DOI: 10.1007/978-3-658-33519-9_4
Open Access
ATLAS-FeliCity: Supporting Energy Retrofit of the Heritage Building Stock Through a Simplified Digital Twin
Polo López, Cristina; Khjoa, Ahmed; Curto, Ivan; Haas, Franziska; Exner, Dagmar; Troi, Alexandra (2022)
Polo López, Cristina; Khjoa, Ahmed; Curto, Ivan; Haas, Franziska; Exner, Dagmar...
Proceedings of EuroSun 2022 - ISES and IEA SHC International Conference on Solar Energy for Buildings and Industry, 1–12.
DOI: 10.18086/eurosun.2022.02.07
Peer Reviewed
BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells
Forkel, Hannes; Grabarczyk, Piotr; Depke, Maren; Troschke-Meurer, Sascha; Simm, Stefan; Hammer, Elke; Michalik, Stephan; Hentschker, Christian; Corleis, Björn; Loyal, Lucie; Zumpe, Maxi; Siebert, Nikolai; Dorhoi, Anca; Thiel, Andreas; Lode, Holger; Völker, Uwe; Schmidt, Christian (2022)
Forkel, Hannes; Grabarczyk, Piotr; Depke, Maren; Troschke-Meurer, Sascha; Simm, Stefan...
Oncoimmunology 11 (1), 2148850.
DOI: 10.1080/2162402X.2022.2148850
Open Access Peer Reviewed
BCL11B, an essential transcription factor for thymopoiesis, regulates also vital processes in post-thymic lymphocytes. Increased expression of BCL11B was recently correlated with the maturation of NK cells, whereas reduced BCL11B levels were observed in native and induced T cell subsets displaying NK cell features. We show that BCL11B-depleted CD8+ T cells stimulated with IL-15 acquired remarkable innate characteristics. These induced innate CD8+ (iiT8) cells expressed multiple innate receptors like NKp30, CD161, and CD16 as well as factors regulating migration and tissue homing while maintaining their T cell phenotype. The iiT8 cells effectively killed leukemic cells spontaneously and neuroblastoma spheroids in the presence of a tumor-specific monoclonal antibody mediated by CD16 receptor activation. These iiT8 cells integrate the innate natural killer cell activity with adaptive T cell longevity, promising an interesting therapeutic potential. Our study demonstrates that innate T cells, albeit of limited clinical applicability given their low frequency, can be efficiently generated from peripheral blood and applied for adoptive transfer, CAR therapy, or combined with therapeutic antibodies.