Droplet-Based Measurements of DNA-Templated Nanoclusters—Towards Point-of-Care Applications
Kluitmann, Jonas; Di Fiore, Stefan; Nölke, Greta; Drese, Klaus Stefan (2025)
Biosensors 15 (7), 417.
DOI: 10.3390/bios15070417
Open Access
Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system
Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel; Schmidt, Johannes; Simm, Stefan; Kalkhof, Stefan; Hildebrand, Janosch; Bosch, Thomas; Winnefeld, Marc; Grönniger, Elke; Siracusa, Annette (2025)
Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel...
Aging (Albany NY) 17 (7), 1784–1809.
Peer Reviewed
Aging is a complex process that significantly contributes to age-related diseases and poses significant challenges for effective interventions, with few holistic anti-aging approaches successfully reversing its signs. Heterochronic parabiosis studies illuminated the potential for rejuvenation through blood-borne factors, yet the specific drivers including underlying mechanisms remain largely unknown and until today insights have not been successfully translated to humans. In this study, we were able to recreate rejuvenation of the human skin via systemic factors using a microphysiological system including a 3D skin model and a 3D bone marrow model. Addition of young human serum in comparison to aged human serum resulted in an improvement of proliferation and a reduction of the biological age as measured by methylation-based age clocks in the skin tissue. Interestingly, this effect was only visible in the presence of bone marrow-derived cells. Further investigation of the bone marrow model revealed changes in the cell population in response to young versus aged human serum treatment. Using proteome analysis, we identified 55 potential systemic rejuvenating proteins produced by bone marrow-derived cells. For seven of these proteins, we were able to verify a rejuvenating effect on human skin cells using hallmarks of aging assays, supporting their role as systemic factors rejuvenating human skin tissue.
Privacy-preserving multicenter differential protein abundance analysis with FedProt
Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine; Barth, Teresa; Schweizer, Lisa; Giesbertz, Pieter; Schmidt, Johannes; Kalkhof, Stefan; Müller-Deile, Janina; van Veelen, Peter; Mohammed, Yassene; Hammer, Elke; Arend, Lis; Adamowicz, Klaudia; Laske, Tanja; Hartebrodt, Anne; Frisch, Tobias; Meng, Chen; Matschinske, Julian; Späth, Julian; Röttger, Richard; Schwämmle, Veit; Hauck, Stefanie; Lichtenthaler, Stefan; Imhof, Axel; Mann, Matthias; Ludwig, Christina; Kuster, Bernhard; Baumbach, Jan; Zolotareva, Olga (2025)
Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine...
Nature Computational Science 5 (8), 675–688.
DOI: 10.1038/s43588-025-00832-7
Peer Reviewed
汽车软件测试基础 (Basiswissen Automotive Softwaretest)
Bongard, R.; Dussa-Zieger, K.; Reißing, Ralf; Schulz, A. (2025)
Schönheit ist funktional. Über die Bedeutung ästhetischer Qualitäten von öffentlichen Räumen für eine Stadtgesellschaft.
Heinrich, Michael (2025)
Immer modern: Aufbruch, Hrsg. Architekten- und Ingenieursverein Berlin-Brandenburg AIV-BB. Wasmuth Verlag, Berlin., 102 - 117.
Gestalterisches Forschen und Kreativität im Bezugsrahmen der Humanorientierung
Heinrich, Michael (2025)
Gestalterisches Forschen, Neuwerk Magazin für Designwissenschaften, Kunsthochschule Burg Giebichenstein, Halle 2025 (1), 122-138.
Ecotoxicological assessment of over-the-counter NSAID (diclofenac, ibuprofen, aspirin) and antipyretic (acetaminophen) pharmaceuticals: A review of their toxicity effects on aquatic crustaceans
Singh, Delezia S.; Pflugmacher Lima, Stephan (2025)
Integrated Environmental Assessment and Management 22(1), 47 - 83.
DOI: 10.1093/inteam/vjaf082
Open Access Peer Reviewed
Commonly used, over-the-counter nonsteroidal anti-inflammatory drugs (OTC NSAIDs) and antipyretic pharmaceuticals represent emerging contaminants of concern, with high global consumption attributing to their frequent detection across diverse water systems. Concerns surround their harmful impacts on aquatic biota, especially because waterbodies represent the predominant receiving matrices for drug-imbued effluents and waste disposal. To support the growing evidence of toxicity effects from emerging contaminants like OTC drugs on nontarget organisms, ecotoxicological assessments have been conducted using bioassay experiments and biological models, like crustaceans. To shed light on the scope of toxicity data on common OTC drugs available for this sensitive group while identifying research gaps and poorly studied areas that need future ecotoxicological attention, the goal focused on reviewing existing literature on toxicity studies that involved crustaceans and commonly used NSAID and antipyretic OTC medications represented by ibuprofen, diclofenac, aspirin/acetylsalicylic acid, and paracetamol/acetaminophen. Published studies were accrued from literature databases using a systematic search strategy and a four-stage protocol. A total of 814 records resulted, with 68 meeting relevance following their eligibility screening against defined criteria. Extracted data were organized according to general bibliographical identifiers, experimental design aspects, and key findings. Assimilated information revealed that most studies focused on acute toxicity testing for the chosen pharmaceuticals using largely microcrustaceans as test models (Branchiopoda, Copepoda, Isopoda, Amphipoda, Ostracoda, and Mysida), especially conventionally known groups (daphnids). Ibuprofen was the most investigated across all taxa (32.9%), but effect concentrations for caridean shrimps (Neocaridina denticulata and Atyaephyra desmarestii) and the amphipod Hyalella azteca reflected notable sensitivity toward diclofenac. Fewer studies assessed mixtures, metabolites, and long-term/sublethal effects in relation to the focus drugs. Future research efforts can supplement these information deficiencies with the aid of efficient nontraditional (ecotoxicological) methodologies within ethical frameworks to support environmental policy and risk management for NSAID and antipyretic pharmaceuticals.
Die Bedeutung von Ästhetik für das Wohlbefinden des Menschen in der gebauten Umwelt
Heinrich, Michael (2025)
Vortrag und Diskussion, Tag der Architektur des BDA, Berlin, WES Landschaftsarchitektur.
Die Vielschichtigkeit ästhetischen Erlebens
Heinrich, Michael (2025)
Impulsvortag und Panelbeitrag, Ligeti-Zentrum, Hamburg (Laboratorien für Innovationen und Gesellschaftliche Entwicklung durch den Transfer von Ideen).
Steuerliche Anerkennung inkongruenter Gewinnausschüttungen
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 37-39.
Abgrenzung von Anlagevermögen und Umlaufvermögen
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 53-56.
Steuerfreiheit von Aufstockungsbeträgen nach dem AltTZG
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 60-63.
Kein Arbeitslohn bei schenkungsweiser Übertragung von Gesellschaftsanteilen zur Sicherung der Unternehmensnachfolge
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 65-68.
Basiszins zur Berechnung der Vorabpauschale gemäß § 18 Abs. 4 InvStG
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 75-77.
Verschmelzung mit steuerlicher Rückwirkung: kein Ausgleich von Gewinnen des Rückwirkungszeitraums mit einem Verlustrücktrag
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 77-80.
Familienstiftung als Finanzunternehmen im Sinne des § 8b Abs. 7 Satz 2 KStG 2011
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 80-83.
Gewinnrücklage bei Übernahme von Pensionsverpflichtungen
Demmler, Uwe (2025)
Steuerrecht aktuell 2025 (1), 57-60.
Real-Time GPU Tree Generation
Kuth, Bastian; Oberberger, Max; Faber, Carsten; Pfeifer, Pirmin; Seyedmasih, Tabaei; Baumeister, Dominik; Meyer, Quirin (2025)
Kuth, Bastian; Oberberger, Max; Faber, Carsten; Pfeifer, Pirmin; Seyedmasih, Tabaei...
Towards Motor Interference of Limb Configuration Changes–A Potential Measure for Human-Likeness of Robots
Mertcan, Kaya; Bauer, Jannik; Nickl, Fabian; Kühnlenz, Kolja Ernst (2025)
Proc of the International Conference on Human-Computer Interaction (HCII).
Peer Reviewed
Wie viel Heizlast ist genug? Einfluss der Heizlast-Berechnungsmethodik auf die Dimensionierung von Wärmepumpen.
Schaub, Michael; Floß, Alexander (2025)
cci Zeitung 2025 (07), 17-18.