This study investigates the social acceptance of integrated photovoltaic (IPV) systems in heritage and landscape contexts, focusing on Italian stakeholders in the construction sector. As part of the “BIPV meets History” research project, this study aims to identify barriers, potentials, drivers, and challenges for widespread PV technology adoption, considering heritage conservation, land preservation, energy production, and climate mitigation. A survey exploring opinions on PV technology integration was conducted. The survey was improved and extended to a total of 271 respondents, using the online method of Computer-Aided Web Interviewing (CAWI), to understand how perceptions of integrated photovoltaics have changed after COVID-19 and the European energy crisis, emphasizing aesthetic, environmental, economic, and personal aspects. The results indicate a general awareness of the technologies, with increasing acceptance in protected contexts, for historic buildings (from 51 to 68%) and especially landscapes (from 44 to 71%), driven by energy and environmental benefits. Cultural concerns, particularly the risk of impacting historical and natural identities, emerge as major barriers. Additionally, it is evident that awareness of PV panel recycling methods is still limited.

Renal cell carcinoma (RCC) is the most common form of kidney cancer, known for its immune evasion and resistance to chemotherapy. Evidence indicates that the SARS-CoV-2 virus may worsen outcomes for RCC patients, as well as patients with diminished renal function. Evidence suggests that the SARS-CoV-2 virus may exacerbate outcomes in RCC patients and those with impaired renal function. This study explored the unidirectional effects of RCC cells and the SARS-CoV-2 spike protein (S protein) on human renal proximal tubule epithelial cells (RPTECs) using a microphysiological approach. We co-cultured RCC cells (Caki-1) with RPTEC and exposed them to the SARS-CoV-2 S protein under dynamic 3D conditions. The impact on metabolic activity, gene expression, immune secretions, and S protein internalization was evaluated. The SARS-CoV-2 S protein was internalized by RPTEC but poorly interacted with RCC cells. RPTECs exposed to RCC cells and the S protein exhibited upregulated expression of genes involved in immunogenic pathways, particularly those related to antigen processing and presentation via the major histocompatibility complex I (MHCI). Additionally, increased TNF-α secretion suggested a pro-inflammatory response. Metabolic shifts toward glycolysis were observed in RCC co-culture, while the presence of the S protein led to minor changes. The presence of RCC cells amplified the immune-modulatory effects of the SARS-CoV-2 S protein on the renal epithelium, potentially exacerbating renal inflammation and fostering tumor-supportive conditions. These findings suggest that COVID-19 infections can impact renal function in the presence of kidney cancer.

The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized. The role of ILDR2 in podocytes, specialized epithelial cells in the kidney, is still unknown. We investigated the role of ILDR2 in glomeruli and its influence on blood filtration. Western blots, single-cell RNA sequencing (scRNA-seq), and superresolution microscopy showed a strong expression of ILDR2 in podocytes that colocalized with the podocyte-specific claudin CLDN5. Co-immunoprecipitation revealed that ILDR2 interacts with CLDN5. In glomerulopathies, induced by nephrotoxic serum and by desoxycorticosterone acetate (DOCA)-salt heminephrectomy, ILDR2 was strongly up-regulated. Furthermore, Ildr2 knockout mice exhibited glomerular hypertrophy and decreased podocyte density. However, they did not develop effacement of podocyte foot processes or proteinuria. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis of isolated glomeruli showed an increase in matrix proteins, such as fibronectin and collagens. This suggests a protective role of ILDR2 in glomerulopathies.

Innerhalb der Berufs- und Wirtschaftspädagogik (BWP) als Teildisziplin der Erziehungswissenschaften nehmen die Themenfelder der Professionalität und Professionalisierung von Lehrkräften zentrale Bereiche in Lehre und Forschung ein. Trotz einer längeren Tradition der Auseinandersetzung mit diesen Themen – man denke nur an den im Jahr 2009 erschienenen Sammelband „Lehrprofessionalität“ von und mit zahlreichen Vertreter:innen der BWP inklusive der Jubilarin – sind die Perspektiven sowohl in der Erziehungswissenschaft allgemein als auch spezifisch in der BWP noch immer heterogen. Sie reichen von strukturfunktionalistischen bis zu kompetenzorientierten Modellierungen, von Charakterisierungen individueller Arbeitsprozesse bis zum koordinierten Zusammenwirken verschiedener Professionsangehöriger, von der Rekonstruktion vollzogener Professionalisierungsschritte als berufsbiografischer Verlauf bis zu Diagnosen der Professionalisierungsbedarfe der etablierten ‚pädagogischen Praxis‘. Dies nehmen wir zum Anlass, ein Klassifikationsraster vorzustellen, mit dem einschlägige Forschungsbeiträge in diesem weitläufigen Themenfeld anhand von sechs grundlegenden Leitfragen geordnet werden können. Anhand beispielhafter Publikationen zeigen wir sodann, wie in der BWP zu diesen Leitfragen in Fachzeitschriften veröffentlicht wird.