Design Strategies for a Sustainable Future
Weinmann, Natalie; Ritz, Franziska (2025)
Vortrag: Creative Skills Week Prague 2025.
Ultrasonic Flow Measurement Using Guided Acoustic Waves: Application of Cylindrical Modes in Pipe Systems
Backer, Alexander; Drese, Klaus Stefan (2025)
Proceedings, 2025 ICU PADERBORN, 9th International Congress on Ultrasonics – ICU 2025, 85-88.
DOI: 10.5162/Ultrasonic2025/A12-b3
Open Access
This paper explores an alternative approach to ultrasonic flow measurement using guided acoustic waves in cylindrical modes. Unlike conventional methods with diagonal sound propagation, the entire pipe including the fluid is excited to vibrate, reducing path-dependent correction factors. A ring-shaped sensor was developed for a DN15 steel pipe. Results show a signal time shift 2.5 times greater than with Lamb wave-based sensors, adjustable over distance. This approach enables precise, non-invasive flow measurement across various pipe diameters.
Stellt euch vor, Innovation wäre ein Studiengang der Wirtschaftsinformatik
Grosch, Christian (2025)
Science Slam, 6. MINT Symposium 2025, Nürnberg.
Handreichung zur Lehre mit (mathematischen) Concept Maps
Pawlowsky, Raik; Rischke, Roman; Wick , Michael (2025)
Tagungsband MINT-Symposium 2025, 395-402.
Open Access Peer Reviewed
Entwicklung innovativer Produktideen projektbasiert lehren und prüfen
Lindner, Alisa; Reißing, Ralf (2025)
6. Symposium zur Hochschullehre in den MINT-Fächern, 153-160.
Open Access Peer Reviewed
Quantitative Ultrasound for Hip Joint Prostheses Osteointegration Monitoring
Lützelberger, Jan (2025)
Talk, 2025 IEEE International Ultrasonics Symposium (IUS), Utrecht, 2025.
Background, Motivation and Objective
Hip joint prostheses (HJP) are increasingly common with an aging population. The most frequent complication is aseptic loosening, linked to bone resorption and a growing soft tissue gap between bone and implant. However, integration monitoring and loosening diagnosis still rely on expensive, static X-ray imaging. Ultrasound, despite cheaper, dynamic, and radiation-free, is not yet viable due to its limits in resolving tissue beyond the bone.
This work presents how a novel quantitative ultrasound (QUS) data processing approach could improve HJP monitoring by quantitatively assessing osteointegration. While the basic concept was already tested on artificial models, we now show first clinical results for ultrasonic thickness measurements of the bone-implant gap at hip implant patients compared to X-ray imaging.
Statement of Contribution/Methods
Our approach is based on an analysis of raw (RF) beamformed ultrasonic data. A scan line perpendicular to the bone surface is extracted and a certain signal range following the dominant bone reflection is transformed to the frequency domain using a Fast Fourier Transform (FFT) (a). The gap thickness, indicating local osteointegration quality and potential loosening signs, is then determined by evaluating the frequency spacing of minima in the amplitude spectrum.
To demonstrate the potential of our QUS method, we analyzed ultrasonic scans from six HJP patients at one fixed position each (sagittal and transversal) using a handheld scanner (C3 HD3, Clarius, Canada) and compared the measured gap thicknesses with x-ray images.
Results/Discussion
(b) shows the gap thicknesses determined using our QUS method in comparison with the visual assessment of corresponding X-ray images. Despite the small sample size and some simplifying assumptions used for this first feasibility test, the clear trend highlights the approach’s potential for assessing local implant integration. The cases where no gap could be seen in the x-ray image illustrate its potential for gap detection beyond X-ray resolution limits.
Besides gap thickness, our QUS approach could also reveal elasticity changes in the soft-tissue gap, potentially indicating critical biofilm formation. Further steps also include extending our method to an automated thickness detection during dynamic scanning and integrating results into B-mode images, e. g., using color coding.
Effizienz von Wärmepumpensystemen: Ursachen und Einfluss des Abfalls der Vorlauftemperatur
Floß, Alexander; Schaub, Michael (2025)
Moderne Gebäudetechnik 2025 (6), 47-49.
Lernen lernen – Stress, Achtsamkeit und Resilienz - Votrag bei der Med School Kloster Banz zu Beginn des Medizinstudiums
Kohls, Niko (2025)
Die Auswirkungen einer 8-wöchigen Yoga-Intervention auf Angst und stressbedingte Symptome bei Brustkrebspatientinnen nach der Akutbehandlung: Protokoll einer randomisierten kontrollierten Studie
Hiller, Annika; Iser, Lilli; Schulz, Juliane; Antwerpen, Cornelia (2025)
DGMP/DGMS Kongress, Jena, Germany. .
Peer Reviewed
Prädiktoren der Effektivität VR-basierter Interventionen zur Stressreduktion: Ein systematisches Review mit Metaanalyse
Strauch, Hannah; Schuil, Isabel; Simm, Stefan; Grubert, Jens; Kalamkar, Snehanjali (2025)
DGMP/DGMS Kongress, Jena, Germany.
Peer Reviewed
Effekte von multisensorischem virtuellem Waldbaden auf Stress und Wohlbefinden von gesunden Erwachsenen – eine randomisierte kontrollierte Studie
Schuil, Isabel; Kalamkar, Snehanjali; Simm, Stefan; Grubert, Jens; Streuber, Stephan (2025)
Schuil, Isabel; Kalamkar, Snehanjali; Simm, Stefan; Grubert, Jens...
DGMP/DGMS Kongress, Jena, Germany.
Single-cell RNA sequencing delineates renal anti-fibrotic mechanisms mediated by TRPC6 inhibition
Xu, Yao; Zheng, Zhihuang; Oswald, Marleen; Cheng, Guozhe; Liu, Jun; Zhai, Qidi; Kruegel, Ute; Schaefer, Michael; Gerhardt, Holger; Endlich, Nicole; Gollasch, Maik; Simm, Stefan; Tsvetkov, Dmitry (2025)
Xu, Yao; Zheng, Zhihuang; Oswald, Marleen; Cheng, Guozhe; Liu, Jun; Zhai, Qidi...
Adv. Sci. (Weinh.) 12 (33), e01175.
Peer Reviewed
Chronic kidney disease (CKD) is characterized by persistent inflammation and tubulointerstitial fibrosis leading to end-stage renal disease. Transient receptor potential canonical 6 (TRPC6) channel inhibition mitigates tubular injury and renal fibrosis in murine models of unilateral ureteral obstruction (UUO) and 2-month chronic post-ischemia-reperfusion injury (2m post-I/R). Through integrated analysis of single-cell-RNA-sequencing (scRNA-Seq) data from UUO mice treated with the selective TRPC6 inhibitor SH045, here the renoprotective cell composition and cell type-specific transcriptional programs are defined. We explored translational aspects by conducting an in-depth scRNA-Seq analysis of kidney samples from patients with CKD. These results reveal global transcriptional shifts with a dramatic diversification of inflammatory cells, endothelial cells and fibroblasts. Notably, a distinct subpopulation of novel endothelial cells is delineated, which is termed ECRIN, that regulate inflammatory networks implicating VEGF and GAS signaling pathways. The data also indicates that inhibition of TRPC6 channels triggers a Prnp transcription factor regulatory network, which contributes to the alleviation of renal fibrosis. The key findings are supported at the protein level by immunofluorescence and western blot analysis. We observed similar patterns in the chronic 2m postI/R injury model. These findings provide novel insights into the potential therapeutic benefits of TRPC6 inhibition in CKD.
Plasma-treated water applied as a foliar spray promotes root growth in barley
Krüger, Andrea; Schlömer, Stefan; Simm, Stefan; Bold, Jessica; Stöhr, Christine (2025)
BMC Plant Biol. 25 (1), 1210.
Open Access Peer Reviewed
Wie der Abfall der Versorgungstemperatur die Effizienz von Wärmepumpensystemen signifikant reduziert
Floß, Alexander; Schaub, Michael (2025)
KI Kälte · Luft · Klimatechnik 61 (08-09), 42-46.
Wärmepumpen (WP) stellen eine Schlüsseltechnologie für die Energiewende im Gebäudesektor dar. Die Erkenntnis, dass die Effizienz von WP vom Temperaturhub zwischen Wärmequelle und Wärmesenke und damit von der benötigten Vorlauftemperatur abhängt, ist mittlerweile weit verbreitet. Vor diesem Hintergrund werden Raumheizeinrichtungen auch so ausgewählt und ausgelegt, dass sie mit einem möglichst niedrigen Temperaturniveau auskommen. Wenig Aufmerksamkeit wird bisweilen aber der Tatsache geschenkt, dass in den hydraulischen Systemen ein Abfall der Vorlauf- bzw. Versorgungstemperatur (Drop of Supply Temperature (DoST)) von der WP bis zum Verbraucher auftritt, der im weiten Bereich zwischen 0 und 20 K variiert. Dies führt mitunter zu einer Effizienzverschlechterung des WP-Betriebs von bis zu 50 %. Der vorliegende Beitrag beschäftigt sich mit den oft vermeidbaren Ursachen und gibt Größenordnungen für den DoST an. Hieraus kann die Effizienzverschlechterung für das Wärmepumpen-System (WPS) nach „CARNOT“ abgeschätzt werden.
Welcome to the ML Team: A Chat Agent as a Project Management Support Agent
Reiche, Michael; Leidner, Jochen L. (2025)
11th Intelligent Systems Conference 2025 (Intellisys'25), 28-29 August 2025, Amsterdam, The Netherlands.
Peer Reviewed
Leistungsgeregelte Wärmepumpen und Pufferspeicher effizient kombinieren
Floß, Alexander; Schaub, Michael (2025)
Moderne Gebäudetechnik Sonderausgabe 2025, 32-35.
FEM-Based Modeling of Guided Acoustic Waves on Free and Fluid-Loaded Plates
Landskron, Johannes; Backer, Alexander; Wolf, Conrad R.; Fischerauer, Gerhard; Drese, Klaus Stefan (2025)
Landskron, Johannes; Backer, Alexander; Wolf, Conrad R.; Fischerauer, Gerhard...
MDPI Applied Sciences 2025 (15), 9116.
DOI: 10.3390/app15169116
Open Access Peer Reviewed
Symptoms of post-traumatic distress and quality of life in adults with aortopathy and congenital heart defects or hereditary connective tissue diseases
Dreher, Helena; Dewald, Oliver; Freiberger, Annika; Freilinger, Sebastian; Harig, Frank; Nagdyman, Nicole; Strueven, Nina; Suleiman, Mathieu; Mellert, Fritz; Kohls, Niko; Kaemmerer-Suleiman, Ann-Sophie (2025)
Dreher, Helena; Dewald, Oliver; Freiberger, Annika; Freilinger, Sebastian; Harig, Frank...
Cardiovascular Diagnosis and Therapy 0 (0).
Open Access Peer Reviewed
Encapsulated biocides in façade materials impact leaching and UV stability, resulting in lower aquatic toxicity of the eluates
Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine; Noll, Matthias; Kalkhof, Stefan (2025)
Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine...
Environmental Science and Pollution Research 2025 (32), 16324-16339.
DOI: 10.1093/etojnl/vgaf156
Peer Reviewed
Motor interference of elbow configuration changes in human-robot interaction
Kaya, Mertcan; Becker, Kevon; Först, Christian; Greve, Jannik; Keller, Jan; Meserle, Maximilian; Siegel, Raphael; Stelzer, Jonas; Kühnlenz, Kolja Ernst (2025)
Kaya, Mertcan; Becker, Kevon; Först, Christian; Greve, Jannik; Keller, Jan...
26 (1), 131-149.
Peer Reviewed
Referat Forschungs- und Drittmittelservice (FDS)
Hochschule Coburg
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Monika SchnabelForschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de