Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-Vaccines
Mandler, Markus; Santic, Radmila ; Gruber , Petra; Cinar, Yeliz ; Pichler, Dagmar ; Funke, Susanne A.; Willbold, Dieter; Schneeberger , Achim ; Schmidt , Walter; Mattner , Frank (2015)
Mandler, Markus; Santic, Radmila ; Gruber , Petra; Cinar, Yeliz ; Pichler, Dagmar ...
PLOS ONE.
DOI: 10.1371/journal.pone.0115237
Open Access Peer Reviewed
Subjective expansion of extended time-spans in experienced meditators
Wittmann, M.; Otten, S.; Schötz, E.; Sarikaya, A.; Lehnen, H.; Jo, H.-G.; Kohls, Niko; Schmidt, S.; Meißner, Karin (2015)
Wittmann, M.; Otten, S.; Schötz, E.; Sarikaya, A.; Lehnen, H.; Jo, H.-G.; Kohls, Niko...
Frontiers in Psychology, 5..
Peer Reviewed
QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015)
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A....
Scientific reports 2015 5, 13222.
DOI: 10.1038/srep13222
Peer Reviewed
Strong evidence exists for a central role of amyloid ß-protein (Aß) oligomers in the pathogenesis of Alzheimer`s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aß aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aß aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.
Kompetenz in Bildung: Die Hochschule in der Bildungsregion Coburg
Hammer, Veronika; Holtorf, Christian (2015)
Coburg 2015.
Subjective expansion of extended time-spans in experienced meditators
Wittmann, M.; Otten, S.; Schötz, E.; Sarikaya, A.; Lehnen, H.; Jo, H.-G.; Kohls, Niko; Schmidt, Sabine; Meißner, Karin (2015)
Wittmann, M.; Otten, S.; Schötz, E.; Sarikaya, A.; Lehnen, H.; Jo, H.-G.; Kohls, Niko...
Frontiers in Psychology 2015 5, 1586.
DOI: 10.3389/fpsyg.2014.01586
Peer Reviewed
Experienced meditators typically report that they experience time slowing down in meditation practice as well as in everyday life. Conceptually this phenomenon may be understood through functional states of mindfulness, i.e., by attention regulation, body awareness, emotion regulation, and enhanced memory. However, hardly any systematic empirical work exists regarding the experience of time in meditators. In the current cross-sectional study, we investigated whether 42 experienced mindfulness meditation practitioners (with on average 10 years of experience) showed differences in the experience of time as compared to 42 controls without any meditation experience matched for age, sex, and education. The perception of time was assessed with a battery of psychophysical tasks assessing the accuracy of prospective time judgments in duration discrimination, duration reproduction, and time estimation in the milliseconds to minutes range as well with several psychometric instruments related to subjective time such as the Zimbardo Time Perspective Inventory, the Barratt Impulsivity Scale and the Freiburg Mindfulness Inventory. In addition, subjective time judgments on the current passage of time and retrospective time ranges were assessed. While subjective judgements of time were found to be significantly different between the two groups on several scales, no differences in duration estimates in the psychophysical tasks were detected. Regarding subjective time, mindfulness meditators experienced less time pressure, more time dilation, and a general slower passage of time. Moreover, they felt that the last week and the last month passed more slowly. Overall, although no intergroup differences in psychophysical tasks were detected, the reported findings demonstrate a close association between mindfulness meditation and the subjective feeling of the passage of time captured by psychometric instruments.
Psychophysiology of duration estimation in experienced mindfulness meditators and matched controls
Otten, S.; Schötz, E.; Wittmann, M.; Schmidt, Sabine; Kohls, Niko; Meißner, Karin (2015)
Frontiers in Psychology 2015 6, 1215.
DOI: 10.3389/fpsyg.2015.01215
Peer Reviewed
Recent research suggests that bodily signals and interoception are strongly related to our sense of time. Mindfulness meditators train to be aware of their body states and therefore could be more accurate at interval timing. In this study, n = 22 experienced mindfulness meditators and n = 22 matched controls performed both, an acoustic and a visual duration reproduction task of 8, 14, and 20 s intervals, while heart rate and skin conductance were continuously assessed. In addition, participants accomplished a heart beat perception task and two selective attention tasks. Results revealed no differences between meditators and controls with respect to performance in duration reproduction or attentional capacities. Additionally no group difference in heart beat perception scores was found. Across all subjects, correlational analyses revealed several associations between performance in the duration reproduction tasks and psychophysiological changes, the latter being also related to heart beat perception scores. Furthermore, former findings of linearly increasing cardiac periods and decreasing skin conductance levels during the auditory duration estimation task (Meissner and Wittmann, 2011) could be replicated, and these changes could also be observed during a visual duration reproduction task. In contrast to our earlier findings, the heart beat perception test was not related with timing performance. Overall, although experienced meditators did not differ from matched controls with respect to duration reproduction and interoceptive awareness, this study adds significantly to the emerging view that time perception is related to autonomic regulation and awareness of body states.
Kulturelle Bildung: Mehr als schöne Worte?
Hammer, Veronika; Holtorf, Christian (2015)
Kompetenz in Bildung. Die Hochschule in der Bildungsregion Coburg, Hochschule Coburg, , 23-25.
Der Nordpol - eine Erzählung
Holtorf, Christian (2015)
in: Safia Azzouni/Stefan Böschen/Carsten Reinhardt (Hg.): Erzählung und Geltung. Wissenschaft zwischen Autorschaft und Autorität. Weilerswist: Velbrück Wissenschaft, 133-155.
Peacebuilding - Gender - Social Work
Franger, G.; Lohrenscheit , Claudia (2015)
Internationale Sozialarbeit / Oldenburg 2015 (12), 10-20.
How to combat Racism against Refugees
Lohrenscheit , Claudia (2015)
Peacebuilding – Gender – Social Work. International Human Rights Dialogue: Celebrating the 100th Anniversary of the Women’s Peace Congress; Paulo Freire Verlag, Oldenburg 2015 (280 Seiten), 208-218.
Das Menschenrecht auf Bildung: ein unerfülltes Versprechen mit viel Potenzial
Lohrenscheit , Claudia (2015)
Huhle, N./ Huhle T.: Die subversive Kraft der Menschenrechte: Rainer Huhle zum radikalen Jubiläum. Paulo Freire Verlag, Oldenburg 2015, 185-196.
Artikel 26
Lohrenscheit , Claudia (2015)
Böhm, O./Katheder, D. (Hg.): Grundkurs Menschenrechte. Die 30 Artikel. Kommentare und Anregungen für die politische Bildung. Nürnberg 2015, 116-131.
Lehren und Prüfen im Requirements Engineering am Beispiel eines Master- Kurses für Ingenieure
Reißing, Ralf (2015)
Workshop Studentische Ausbildung und Weiterbildung in Anforderungsspezifikationen (SAGWAS), Oktober 2015, Cottbus. In: Cunningham, D.; Hofstedt, P.; Meer, K.; Schmitt, I. (Hrsg.): Informatik 2015. Lecture Notes in Informatics (LNI), Gesellschaft für Informatik, , 623-624.
Peer Reviewed
Mindful in a random forest: Assessing the validity of mindfulness items using random forests methods
Sauer, S.; Lemke, J.; Zinn, W.; Büttner, R.; Kohls, Niko (2015)
Personality and Individual Differences 81, 117-123..
DOI: 10.1016/j.paid.2014.09.011
Peer Reviewed
No effect of the cyclooxygenase-2 inhibitor etoricoxib on pre-emptive and post-operative analgesia in visceral surgery: results of a randomized controlled trial
Fleckenstein , J.; Kohls, Niko; Evtouchenko, E.; Lohmeyer, L.; Kramer, S.; Lang , P. M. ; Siebeck , M. ; Mussak , T. ; Hatz , R. ; Heindl , B. ; Conzen , P.; Rehm, M. ; Czerner , S. ; Zwißler, B. ; Irnich , D. (2015)
Fleckenstein , J.; Kohls, Niko; Evtouchenko, E.; Lohmeyer, L.; Kramer, S....
European Journal of Pain. 20 (2).
DOI: 10.1002/ejp.699
Open Access Peer Reviewed
E-learning innovations for the education of general practitioners at the Bavarian Virtual University (BVU) – a model for other countries
Vogel , B.; Karmann, C. ; Mehring , M. ; Schneider, A.; Offenbächer, M.; Kohls, Niko; Schelling, J. (2015)
Vogel , B.; Karmann, C. ; Mehring , M. ; Schneider, A.; Offenbächer, M.; Kohls, Niko...
Bio-Algorithms and Med-Systems.
DOI: 10.1515/bams-2015-0006
Open Access Peer Reviewed
Kompetenz in Bildung: Die Hochschule in der Bildungsregion Coburg
Hammer, Veronika; Holtorf, Christian (2015)
DCT: Coburg .
Integrierte Stadtentwicklung und die Gestaltung nachhaltiger Mobilität: Zum Stand der Planungspraxis am Beispiel der Stadt Leipzig
Blechschmidt, Andreas; Lanzendorf, Martin; Wilde, Mathias (2015)
Raumforschung und Raumordnung 73 (6), 423-437.
DOI: 10.1007/s13147-015-0372-5
Peer Reviewed
Die Re-Organisation der Verkehrssysteme: Warum sich die städtische Verkehrsplanung zu einer Mobilitätsplanung weiterentwickeln sollte
Wilde, Mathias (2015)
Standort - Zeitschrift für Angewandte Geographie 39 (1), 22-25.
DOI: 10.1007/s00548-015-0364-2
Mobilität im ländlichen Raum
Wilde, Mathias (2015)
Handbuch der kommunalen Verkehrsplanung: für die Praxis in Stadt und Region.
Peer Reviewed