Das Bauen neu denken
Heinrich, Michael (2024)
Echt Oberfranken, Regionalmagazin 2024 (71).
Long-term monitoring data of hygrothermal conditions of a retrofitted historic building in Settequerce, South Tyrol (Italy)
Panico, Simone; Larcher, Marco; Herrera-Avellanosa, Daniel; Cennamo, David; Troi, Alexandra (2024)
Panico, Simone; Larcher, Marco; Herrera-Avellanosa, Daniel; Cennamo, David...
Data in Brief 53, 110137.
DOI: 10.1016/j.dib.2024.110137
Open Access Peer Reviewed
Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Kliewe, Felix; Siegerist, Florian; Hammer, Elke; Al-Hasani, Jaafar; Amling, Theodor; Hollemann, Jonas; Schindler, Maximilian; Drenic, Vedran; Simm, Stefan; Amann, Kerstin; Daniel, Christoph; Lindenmeyer, Maja; Hecker, Markus; Völker, Uwe; Endlich, Nicole (2024)
Kliewe, Felix; Siegerist, Florian; Hammer, Elke; Al-Hasani, Jaafar; Amling, Theodor...
Communications Biology 7 (1), 446.
DOI: 10.1038/s42003-024-06125-5
Open Access Peer Reviewed
Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in podocytes after mechanical stretch and relocalizes from focal adhesions to actin filaments. In zyxin knockout podocytes, we found that the loss of zyxin reduced the expression of vinculin and VASP as well as the expression of matrix proteins, such as fibronectin. This suggests that zyxin is a central player in the translation of mechanical forces in podocytes. In vivo, zyxin is highly up-regulated in patients suffering from diabetic nephropathy and in hypertensive DOCA-salt treated mice. Furthermore, zyxin loss in mice resulted in proteinuria and effacement of podocyte foot processes that was measured by super resolution microscopy. This highlights the essential role of zyxin for podocyte maintenance in vitro and in vivo, especially under mechanical stretch.
EWIG Erfahrungswissen teilen – intergenerativ lernen: Chancen nachhaltigen Handelns für eine gesellschaftliche Transformation im Hochschulsetting
Esslinger, Adelheid Susanne; Schadt, Christian (2024)
Srpinger: Herausgeberband.
DOI: 10.1007/978-3-662-67740-7_1
PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods.
Freilinger, Sebastian; Kohls, Niko; Kaemmerer, Harald (2024)
BMC Cardiovascular Disorders 24 (1), 181.
DOI: 10.1186/s12872-024-03833-y
Open Access Peer Reviewed
Simulationsgetrieben Auslegungs- und Optimierungsstrategie für den Anwendungsfall eines Axialventilators mit Leitapparat
Fritsche, Manuel (2024)
Dissertation. Friedrich-Alexander-Universität Erlangen-Nürnberg, 2024.
Peer Reviewed
Homo Narrans: From Information to Narratives
Leidner, Jochen L. (2024)
Invited Keynote, Seventh International Workshop on Narrative Extraction from Texts (Text2Story 2024) held in conjunction with the 46th European Conference on Information Retrieval (ECIR 2024), Glasgow, Scotland, UK, 23 March 2024.
Enzymatic machinery of wood-inhabiting fungi that degrade temperate tree species
Kipping, Lydia; Jehmlich, N.; Moll, Julia; Noll, Matthias; Gossner, Martin M.; Bossche, Tim van den; Edelmann, Pascal; Borken , W.; Hofrichter, M.; Kellner, H. (2024)
Kipping, Lydia; Jehmlich, N.; Moll, Julia; Noll, Matthias; Gossner, Martin M....
The ISME Journal 2024/18/1, wrae050.
DOI: 10.1093/ismejo/wrae050
Open Access Peer Reviewed
Versatile platform for mobile detection of environmental pollutants using DNA Quantum Clusters
Kluitmann, Jonas; Drese, Klaus Stefan (2024)
Vortrag auf dem 12th Workshop of Chemical and Biological Micro Laboratory Technology CBM2024 in Ilmenau, März 2024.
Environmental pollution is an ever-growing concern. Industrial sites as well as agricultural use areas can bear immense harmful burdens. Unintentionally improperly disposed of wastes as well as illegally dumped chemicals pose additional risks in the environment, while remains of pharmaceuticals are a regular concern in sources of drinking water. Pollutants such as PFAS and microplastics could even be detected in the most remote regions of the earth and are known for adverse effects on humans and their environment. Establishing a comprehensive overview of where pollution of which severity and with what substances occurs is thus important, so remediations can be planned and prioritized. This necessitates fast, versatile, reliable and cheap measurements, ideally directly at sampling sites.
A promising class of transducers for detecting a multitude of pollutants are DNA Quantum Clusters. QC:DNA are highly sensitive and selective transducers for many substances, showing responses in their fluorescent behaviors based on their chemical environment. Based on the specific design, QC:DNA can interact with different chemical species and exhibit tuned excitation and emission wavelengths.
For the use of such transducers, we present a fluorescence reader integrated around capillaries. The system is designed for easy and fast customization for a large range of excitation and emission wavelengths while focusing on system portability and striving for affordability. The microfluidic system controlling and performing the assay is based on droplet sequences to facilitate fast mixing while allowing for incubation times with minimal dispersion and enabling a temporary storage and a precise processing of samples.
Die Entwicklung von individueller, gesellschaftlicher und planetarischer Resilienz - Achtsamkeit und ihre Bedeutsamkeit für Umwelt-, Klimaschutz und Nachhaltigkeit
Kohls, Niko; Pollan, Sandra; Heinrich, Michael (2024)
Erfolgsformel Achtsamkeit: Bewusst führen, nachhaltig gewinnen, Hrsg. Weifenbach, M., Litego Verlag 2024.
Peer Reviewed
Ultrasonic Interferometric Procedure for Quantifying Prosthesis Loosening
Lützelberger, Jan (2024)
Invited Talk, 87th Annual Meeting of the DPG - Deutsche Physikalische Gesellschaft, Berlin, 2024.
Loosening of an artificial hip joint is a frequent complication in orthopedics and trauma surgery. Due to a lack of accuracy, conventional diagnostic methods such as projection radiography cannot reliably diagnose loosening in its early stages or detect whether it is associated with the formation of a biofilm in the bone-implant interface.
In this work, we developed an ultrasonic measurement procedure for quantifying the thickness of the layer between bone and prosthesis as a correlate to loosening. In principle, it also allows for the material characterization of the interface. An analytical model for the reflection of sound waves in a three-layer system was combined with a new data processing method to face the challenges of the specific medical application. By non-linear fitting the theoretical prediction of the model to the actual shape of the reflected sound waves in frequency domain, the thickness of the interlayer can be determined and predictions about its physical properties are possible. The presented approach was successfully applied to idealized test systems and a bone-implant system for thickness determination in the range of approx. 200 µm to 2 mm [1].
The talk will focus on the physical background and the key concepts of the procedure as well as on representative experiments, but also highlight its future potential in medical application.
[1] J. Lützelberger et al., Sensors 23, 5942 (2023)
Mesh shaders on AMD RDNA™ graphics cards: Procedural grass rendering
Faber, Carsten; Kuth, Bastian; Oberberger, Max; Meyer, Quirin (2024)
Open Access
Wärmepumpen in Mehrfamilienhäusern – Mythen & Einsatzmöglichkeiten bzw. -grenzen
Schaub, Michael (2024)
Online-Infoveranstaltung der ENERGIEregion Nürnberg e.V..
The healing seven: how architecture impacts health.
Koppen, Gemma (2024)
Ringvorlesung: Health, Environment and Architecture – Discourses from the Past, Challenges for the Present, Perspectives for the Future, University of Durham, Durham.
Die Superkraft der Resilienz: Wie wir lernen, gesund & stark zu bleiben
Kohls, Niko (2024)
Gefangen in der Positivitätsfalle: Wann das Immer-Glücklich-Sein gefährlich wird
Kohls, Niko (2024)
Gefangen in der Positivitätsfalle: Wann das Immer-Glücklich-Sein gefährlich wird.
Mesh shaders on AMD RDNA™ graphics cards: Font- and vector-art rendering with mesh shaders
Kuth, Bastian; Oberberger, Max; Meyer, Quirin (2024)
Open Access
Wärmepumpen im Wohngebäude-Bestand– Kältemittel, Einsatzgrenzen, Hybridsysteme
Schaub, Michael (2024)
Online-Tagung des BTGA „BEG und Großwärmepumpen - Übersicht und aktuelle Informationen“.
DOI: 10.13140/RG.2.2.29962.27847
Open Access
Tau targeting D-peptides as a potential therapeutic approach for Alzheimer’s Disease
Funke, Susanne A. (2024)
AD/PD Conference 2024, Lissabon.
Clinical Social Work in Germany: Development, current state and future challenges
Pauls, Helmut; Gabriel, Maite; Kröger, Christine; Wesenberg, Sandra; Gahleitner, S. (2024)
1. Aufl., ZKS Medien Verlag, Höchberg.
Peer Reviewed