Künstliche Intelligenz: Trends, Gefahren und Chancen
Interview für Radio Plassenburg, Sendung Heimat ist..., 7.2.2024.
Vorstellung des Forschungsprojekts AI4Coping
Meißner, Karin; Grubert, Jens (2024)
Interview im TV Oberfranken, Sendung 4you: Das neue Hochschulmagazin.
Open Access
Quelle: TV Oberfranken
Mapping expectancy-based appetitive placebo effects onto the brain in women
Khalid, Iraj ; Rodrigues, Belina ; Dreyfus, Hippolyte ; Frileux, Solène ; Meißner, Karin; Fossati, Philippe ; Hare, Todd Anthony ; Schmidt, Liane (2024)
Khalid, Iraj ; Rodrigues, Belina ; Dreyfus, Hippolyte ; Frileux, Solène ...
Nature Communications 15, 248 | 1-16.
DOI: 10.1038/s41467-023-44569-1
Open Access Peer Reviewed
Low dose ribosomal DNA P-loop mutation affects development and enforces autophagy in Arabidopsis
Shanmugam, Thiruvenkadam; Chaturvedi, Palak; Streit, Deniz; Ghatak, Arindam; Bergelt, Thorsten; Simm, Stefan; Weckwerth, Wolfram; Schleiff, Enrico (2024)
Shanmugam, Thiruvenkadam; Chaturvedi, Palak; Streit, Deniz; Ghatak, Arindam...
RNA biology 21 (1), 1–15.
DOI: 10.1080/15476286.2023.2298532
Open Access Peer Reviewed
Arabidopsis contains hundreds of ribosomal DNA copies organized within the nucleolar organizing regions (NORs) in chromosomes 2 and 4. There are four major types of variants of rDNA, VAR1-4, based on the polymorphisms of 3’ external transcribed sequences. The variants are known to be differentially expressed during plant development. We created a mutant by the CRISPR-Cas9-mediated excision of ~ 25 nt from predominantly NOR4 ribosomal DNA copies, obtaining mosaic mutational events on ~ 5% of all rDNA copies. The excised region consists of P-loop and Helix-82 segments of 25S rRNA. The mutation led to allelic, dosage-dependent defects marked by lateral root inhibition, reduced size, and pointy leaves, all previously observed for defective ribosomal function. The mutation in NOR4 led to dosage compensation from the NOR2 copies by elevated expression of VAR1 in mutants and further associated single-nucleotide variants, thus, resulting in altered rRNA sub-population. Furthermore, the mutants exhibited rRNA maturation defects specifically in the minor pathway typified by 32S pre-rRNA accumulation. Density-gradient fractionation and subsequent RT-PCR of rRNA analyses revealed that mutated copies were not incorporated into the translating ribosomes. The mutants in addition displayed an elevated autophagic flux as shown by the autophagic marker GFP-ATG8e, likely related to ribophagy.
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS-Like Zebrafish Model
Schindler, Maximilian; Siegerist, Florian; Lange, Tim; Simm, Stefan; Bach, Sophia-Marie; Klawitter, Marianne; Gehrig, Jochen; Gul, Sheraz; Endlich, Nicole (2023)
Schindler, Maximilian; Siegerist, Florian; Lange, Tim; Simm, Stefan; Bach, Sophia-Marie...
Journal of the American Society of Nephrology: JASN 34 (12), 1977–1990.
DOI: 10.1681/ASN.0000000000000235
Open Access Peer Reviewed
BACKGROUND: FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss of filtration barrier function and the development of sclerotic lesions. Therapies to treat FSGS are limited, and podocyte-specific drugs are unavailable. To address the need for treatments to delay or stop FSGS progression, researchers are exploring the repurposing of drugs that have been approved by the US Food and Drug Administration (FDA) for other purposes. METHODS: To identify drugs with potential to treat FSGS, we used a specific zebrafish screening strain to combine a high-content screening (HCS) approach with an in vivo model. This zebrafish screening strain expresses nitroreductase and the red fluorescent protein mCherry exclusively in podocytes (providing an indicator for podocyte depletion), as well as a circulating 78 kDa vitamin D-binding enhanced green fluorescent protein fusion protein (as a readout for proteinuria). To produce FSGS-like lesions in the zebrafish, we added 80 µ M metronidazole into the fish water. We used a specific screening microscope in conjunction with advanced image analysis methods to screen a library of 138 drugs and compounds (including some FDA-approved drugs) for podocyte-protective effects. Promising candidates were validated to be suitable for translational studies. RESULTS: After establishing this novel in vivo HCS assay, we identified seven drugs or compounds that were protective in our FSGS-like model. Validation experiments confirmed that the FDA-approved drug belinostat was protective against larval FSGS. Similar pan-histone deacetylase inhibitors also showed potential to reproduce this effect. CONCLUSIONS: Using an FSGS-like zebrafish model, we developed a novel in vivo HCS assay that identified belinostat and related pan-histone deacetylase inhibitors as potential candidates for treating FSGS.
Evaluation of crowdsourced mortality prediction models as a framework for assessing artificial intelligence in medicine
Bergquist, Timothy; Schaffter, Thomas; Yan, Yao; Yu, Thomas; Prosser, Justin; Gao, Jifan; Chen, Guanhua; Charzewski, Łukasz; Nawalany, Zofia; Brugere, Ivan; Retkute, Renata; Prusokas, Alidivinas; Prusokas, Augustinas; Choi, Yonghwa; Lee, Sanghoon; Choe, Junseok; Lee, Inggeol; Kim, Sunkyu; Kang, Jaewoo; Mooney, Sean; Guinney, Justin; Consortium, Patient (2023)
Bergquist, Timothy; Schaffter, Thomas; Yan, Yao; Yu, Thomas; Prosser, Justin...
Journal of the American Medical Informatics Association: JAMIA 31 (1), 35–44.
DOI: 10.1093/jamia/ocad159
Open Access Peer Reviewed
OBJECTIVE: Applications of machine learning in healthcare are of high interest and have the potential to improve patient care. Yet, the real-world accuracy of these models in clinical practice and on different patient subpopulations remains unclear. To address these important questions, we hosted a community challenge to evaluate methods that predict healthcare outcomes. We focused on the prediction of all-cause mortality as the community challenge question. MATERIALS AND METHODS: Using a Model-to-Data framework, 345 registered participants, coalescing into 25 independent teams, spread over 3 continents and 10 countries, generated 25 accurate models all trained on a dataset of over 1.1 million patients and evaluated on patients prospectively collected over a 1-year observation of a large health system. RESULTS: The top performing team achieved a final area under the receiver operator curve of 0.947 (95% CI, 0.942-0.951) and an area under the precision-recall curve of 0.487 (95% CI, 0.458-0.499) on a prospectively collected patient cohort. DISCUSSION: Post hoc analysis after the challenge revealed that models differ in accuracy on subpopulations, delineated by race or gender, even when they are trained on the same data. CONCLUSION: This is the largest community challenge focused on the evaluation of state-of-the-art machine learning methods in a healthcare system performed to date, revealing both opportunities and pitfalls of clinical AI.
Alzheimer-Demenz - Neue Therapieoptionen?
Funke, Susanne A.; Funke, Susanne A. (2023)
Kongress des TAO-Gesundheitsjahres 2023 / Hochschule Hof.
Physicians’ experiences of treating long COVID with traditional Chinese medicine ‐ a cross‐sectional survey
Kraft, Jana; Hardy, Anne; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina; Ziegler, Birgit; Meißner, Karin (2023)
Kraft, Jana; Hardy, Anne; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina...
Vortrag und Posterpräsentation auf 22. Deutschen Kongresses für Versorgungsforschung 2023, 4.-6.10.2023, Berlin.
Peer Reviewed
Treatment of Long/Post-COVID with Traditional Chinese Medicine (TCM) –a cross-sectional survey of TCM physicians
Hardy, Anne; Kraft, Jana; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina; Ziegler, Birgit; Meißner, Karin (2023)
Hardy, Anne; Kraft, Jana; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina...
Poster auf 20. Internationalem TAO Kongress 2023, Graz, Österreich.
Open Access Peer Reviewed
The effects of pilates and open-label placebos on severe primary dysmenorrhea - a randomized controlled pilot study
Ort, Sandra; Waibl, Paula; Stang, Marina; Funke, Susanne A.; Dalkner, Nina; Meißner, Karin (2023)
Ort, Sandra; Waibl, Paula; Stang, Marina; Funke, Susanne A.; Dalkner, Nina...
German Journal of Sports Medicine 74 (4), 151.
Peer Reviewed
Neue Therapieoptionen für die Alzheimer-Demenz?
Funke, Susanne A. (2023)
Demenzabend im Rahmen des TAO-Themenjahres 2023 - Gesundheit / Alte Kühlhalle Coburg .
Stress reduction through qigong, taiji, and acupressure
Meißner, Karin (2023)
Vortrag auf 6. SMS-Kongress "Chinesische Medizin im klinischen Alltag — Grundlagen, Anwendung & Wissenschaft", 8.-10.09.2023, Tutzing.
Peer Reviewed
Treatment of Long/Post-COVID with Traditional Chinese Medicine (TCM) –a cross-sectional survey of TCM physicians
Hardy, Anne; Kraft, Jana; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina; Ziegler, Birgit; Meißner, Karin (2023)
Hardy, Anne; Kraft, Jana; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina...
Poster auf 6. SMS-Kongress "Chinesische Medizin im klinischen Alltag — Grundlagen, Anwendung & Wissenschaft", 8.-10. September 2023, Tutzing.
Peer Reviewed
Trace Analysis of Metal(II) Pyrithiones in Building Materials by means of Adsorptive Stripping Voltammetry
Befolo, Olivier; Flechsig, Gerd-Uwe (2023)
Wissenschaftliches Poster: 74th Annual Meeting of the International Society of Electrochemistry in Lyon, France 2023.
Lebensqualität fördern mit Bewegung und Entspannung
Meißner, Karin (2023)
Vortrag auf dem Themenabend "Krebs –Was kann ich für mein Wohlbefinden tun?", TAO Themenjahr2023 – Gesundheit.
Placebo, nocebo & empathy
Meißner, Karin (2023)
Vortrag in Workshop "The role of empathy, placebo and nocebo effects to make every contact count (MECC) in healthcare" des "StoneygateCentre for Empathic Healthcare" (Chair: Prof. Dr. Jeremy Howick).
Die Rolle der Psyche in der Therapie: Placeboeffekte
Meißner, Karin (2023)
IMPULSTAGUNG 2.0 -PSYCHISCHE GESUNDHEIT SICHTBAR MACHEN, Klinische Abteilung für Psychiatrie und Psychotherapeutische Medizin, Universitätsklinikum Graz, 14.06.2023.
Placebo effects on nausea and motion sickness are resistant to experimentally-induced stress
Jacob, Carmen; Olliges, Elisabeth; Haile, A.; Hoffmann, Verena; Jacobi, Benjamin; Steinkopf, L.; Lanz, M.; Wittmann, M.; Tschöp, M. H.; Meißner, Karin (2023)
Jacob, Carmen; Olliges, Elisabeth; Haile, A.; Hoffmann, Verena; Jacobi, Benjamin...
Scientific Reports 13 (1), 9908.
DOI: 10.1038/s41598-023-36296-w
Open Access Peer Reviewed
Gesundheitsförderung und Prävention durch Gesundheitscoaches in der Routineversorgung – eine qualitative Interviewstudie mit Ärztinnen und Ärzten
Waibl, Paula; Rothenhäusler, Lena; Nöfer, Eberhard; Meißner, Karin (2023)
Prävention und Gesundheitsförderung 19, 250–258 .
DOI: 10.1007/s11553-023-01047-2
Open Access Peer Reviewed
Gesundheitsökonomische Bewertung einer open-label Placebo Intervention bei funktionellem Post-COVID Syndrom: Studienprotokoll
Hamberger, Jens; Hinterberger, T.; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva; Weimer, K. (2023)
Hamberger, Jens; Hinterberger, T.; Loew, T.; Meißner, Karin; Beschoner, Petra...
ePoster, Deutscher Kongress für Psychosomatische Medizin und Psychotherapie (DKPM), 22-24.06.2022, Berlin.
Peer Reviewed
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