Biocide-containing facades alter culture-based bacterial and fungal community composition and resistance patterns to Octylisothiazolinone
Ciok, Michal; Diener, Julia; Otte, Franziska; Nichterlein, Moritz; Kalkhof, Stefan; Noll, Matthias (2025)
Ciok, Michal; Diener, Julia; Otte, Franziska; Nichterlein, Moritz; Kalkhof, Stefan...
MDPI Microorganisms 2025 (13), 2284.
DOI: 10.3390/microorganisms13102284
Open Access Peer Reviewed
The enrichment of nitrogen-fixing bacteria on biodegradable plastics during the early stage of degradation under agricultural soil conditions and changing climate.
Tanunchai, Benjawan; Nonthijun, Parada; Schädler , M.; Disayathanoowat, Terd; Noll, Matthias (2025)
Tanunchai, Benjawan; Nonthijun, Parada; Schädler , M.; Disayathanoowat, Terd...
Journal of Hazardous Materials Advances 2025 (vgaf156).
DOI: 10.1016/j.hazadv.2025.100793
Peer Reviewed
To address the issue of plastic pollution, biodegradable plastics have been developed as an alternative to conventional
non-biodegradable plastics. Nitrogen(N)-fixing bacteria have been shown to play a pivotal role in the
microbial degradation of biodegradable plastics. However, little is known about how N-fixing bacteria respond to
plastic degradation in agricultural practice. Therefore, this study aimed to (i) provide insights into the N-fixing
bacteria associated with biodegradable plastics during the early stage of degradation (after 60 days of exposure),
and (ii) examine the impact of agricultural practices and climate simulations on the enrichment of N-fixing
bacteria across various plastic types: poly(butylene succinate) (PBS), polybutylene adipate terephthalate (PBAT),
and polyethylene (PE) as a reference. Our findings revealed that N-fixing bacterial genera, particularly Sphingomonas,
Hymenobacter, Massilia, and Methylobacterium-Methylorubrum, outcompete other N-fixing bacteria in the
plastisphere at the early degradation stage, while they are almost absent in the initial soils. These bacterial
groups have been previously linked to plastic degradation and the production of plastic-degrading enzymes.
Moreover, our results indicate that agricultural practices and climate conditions did not significantly affect the
enrichment of N-fixing bacteria. Instead, this study explored the enrichment of these bacteria on biodegradable
plastics, particularly PBAT and PBS, under changing climate and land use conditions during the early degradation
phase. Additionally, we identified soil-associated minor N-fixing bacteria that dominate these N-poor
plastics in both conventional and organic farming systems. Identifying plastic-preferring microbial groups is
crucial for understanding the microbial plastic degradation process under the real world’s scenario.
Die Auswirkungen einer 8-wöchigen Yoga-Intervention auf Angst und stressbedingte Symptome bei Brustkrebspatientinnen nach der Akutbehandlung: Protokoll einer randomisierten kontrollierten Studie
Hiller, Annika; Iser, Lilli; Schulz, Juliane; Antwerpen, Cornelia (2025)
DGMP/DGMS Kongress, Jena, Germany. .
Peer Reviewed
Prädiktoren der Effektivität VR-basierter Interventionen zur Stressreduktion: Ein systematisches Review mit Metaanalyse
Strauch, Hannah; Schuil, Isabel; Simm, Stefan; Grubert, Jens; Kalamkar, Snehanjali (2025)
DGMP/DGMS Kongress, Jena, Germany.
Peer Reviewed
Effekte von multisensorischem virtuellem Waldbaden auf Stress und Wohlbefinden von gesunden Erwachsenen – eine randomisierte kontrollierte Studie
Schuil, Isabel; Kalamkar, Snehanjali; Simm, Stefan; Grubert, Jens; Streuber, Stephan (2025)
Schuil, Isabel; Kalamkar, Snehanjali; Simm, Stefan; Grubert, Jens...
DGMP/DGMS Kongress, Jena, Germany.
Single-cell RNA sequencing delineates renal anti-fibrotic mechanisms mediated by TRPC6 inhibition
Xu, Yao; Zheng, Zhihuang; Oswald, Marleen; Cheng, Guozhe; Liu, Jun; Zhai, Qidi; Kruegel, Ute; Schaefer, Michael; Gerhardt, Holger; Endlich, Nicole; Gollasch, Maik; Simm, Stefan; Tsvetkov, Dmitry (2025)
Xu, Yao; Zheng, Zhihuang; Oswald, Marleen; Cheng, Guozhe; Liu, Jun; Zhai, Qidi...
Adv. Sci. (Weinh.) 12 (33), e01175.
Peer Reviewed
Chronic kidney disease (CKD) is characterized by persistent inflammation and tubulointerstitial fibrosis leading to end-stage renal disease. Transient receptor potential canonical 6 (TRPC6) channel inhibition mitigates tubular injury and renal fibrosis in murine models of unilateral ureteral obstruction (UUO) and 2-month chronic post-ischemia-reperfusion injury (2m post-I/R). Through integrated analysis of single-cell-RNA-sequencing (scRNA-Seq) data from UUO mice treated with the selective TRPC6 inhibitor SH045, here the renoprotective cell composition and cell type-specific transcriptional programs are defined. We explored translational aspects by conducting an in-depth scRNA-Seq analysis of kidney samples from patients with CKD. These results reveal global transcriptional shifts with a dramatic diversification of inflammatory cells, endothelial cells and fibroblasts. Notably, a distinct subpopulation of novel endothelial cells is delineated, which is termed ECRIN, that regulate inflammatory networks implicating VEGF and GAS signaling pathways. The data also indicates that inhibition of TRPC6 channels triggers a Prnp transcription factor regulatory network, which contributes to the alleviation of renal fibrosis. The key findings are supported at the protein level by immunofluorescence and western blot analysis. We observed similar patterns in the chronic 2m postI/R injury model. These findings provide novel insights into the potential therapeutic benefits of TRPC6 inhibition in CKD.
Plasma-treated water applied as a foliar spray promotes root growth in barley
Krüger, Andrea; Schlömer, Stefan; Simm, Stefan; Bold, Jessica; Stöhr, Christine (2025)
BMC Plant Biol. 25 (1), 1210.
Open Access Peer Reviewed
Symptoms of post-traumatic distress and quality of life in adults with aortopathy and congenital heart defects or hereditary connective tissue diseases
Dreher, Helena; Dewald, Oliver; Freiberger, Annika; Freilinger, Sebastian; Harig, Frank; Nagdyman, Nicole; Strueven, Nina; Suleiman, Mathieu; Mellert, Fritz; Kohls, Niko; Kaemmerer-Suleiman, Ann-Sophie (2025)
Dreher, Helena; Dewald, Oliver; Freiberger, Annika; Freilinger, Sebastian; Harig, Frank...
Cardiovascular Diagnosis and Therapy 0 (0).
Open Access Peer Reviewed
Encapsulated biocides in façade materials impact leaching and UV stability, resulting in lower aquatic toxicity of the eluates
Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine; Noll, Matthias; Kalkhof, Stefan (2025)
Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine...
Environmental Science and Pollution Research 2025 (32), 16324-16339.
DOI: 10.1093/etojnl/vgaf156
Peer Reviewed
Systematic Comparison of Bone Proteome Extraction Methods to Allow for Integrated Proteomics–Metabolomics Correlation
Wiltzsch, Vivien; Schmidt, Johannes; Adamowicz, Klaudia; Lauterbach, Theresa; Lehmann, Jörg; Baumbach, Jan; Laske, Tanja; Kalkhof, Stefan (2025)
Wiltzsch, Vivien; Schmidt, Johannes; Adamowicz, Klaudia; Lauterbach, Theresa...
Journal of Proteome Research 24 (9), 4362–4376.
DOI: 10.1021/acs.jproteome.4c01060
Peer Reviewed
Neurocognitive Factors in Spiritual Experiences and Practices
Kohls, Niko; Giordano, James (2025)
, 1–13.
DOI: 10.1007/978-3-031-38971-9_1976-1
Peer Reviewed
Forgiveness and Physical Health: A Review of Theory and Evidence
Toussaint, Loren; Webb, Jon; Hirsch, Jameson; Kohls, Niko; Offenbaecher, Martin; Dezutter, Jessie; Nguyen, Quang; Vallejo, Miguel; Sirois, Fuschia (2025)
Toussaint, Loren; Webb, Jon; Hirsch, Jameson; Kohls, Niko; Offenbaecher, Martin...
, 245–268.
DOI: 10.1007/978-3-031-89095-6_11
Peer Reviewed
This chapter offers an overview of the forgiveness and health connection. We offer a review of common ways to define forgiveness of others and self-forgiveness. Stress-and-coping theories of forgiveness of others and self-forgiveness are outlined. Both theories consider antecedents, correlates, and health outcomes of forgiveness of others and self-forgiveness and both offer a comprehensive and interpretive lens through which to view empirical research on associations between forgiveness of others and self-forgiveness with health outcomes. In reviewing 73 studies, we found seventy-five percent showed at least one connection between a dimension of forgiveness and a physical health outcome. We conclude by integrating and interpreting the research literature, identifying caveats and limitations, and offering a research agenda. Researchers and practitioners are encouraged to think broadly and model forgiveness-health relationships on established psychological and health theories and to execute theory-guided studies of the forgiveness and health connection.
Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system
Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel; Schmidt, Johannes; Simm, Stefan; Kalkhof, Stefan; Hildebrand, Janosch; Bosch, Thomas; Winnefeld, Marc; Grönniger, Elke; Siracusa, Annette (2025)
Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel...
Aging (Albany NY) 17 (7), 1784–1809.
Peer Reviewed
Aging is a complex process that significantly contributes to age-related diseases and poses significant challenges for effective interventions, with few holistic anti-aging approaches successfully reversing its signs. Heterochronic parabiosis studies illuminated the potential for rejuvenation through blood-borne factors, yet the specific drivers including underlying mechanisms remain largely unknown and until today insights have not been successfully translated to humans. In this study, we were able to recreate rejuvenation of the human skin via systemic factors using a microphysiological system including a 3D skin model and a 3D bone marrow model. Addition of young human serum in comparison to aged human serum resulted in an improvement of proliferation and a reduction of the biological age as measured by methylation-based age clocks in the skin tissue. Interestingly, this effect was only visible in the presence of bone marrow-derived cells. Further investigation of the bone marrow model revealed changes in the cell population in response to young versus aged human serum treatment. Using proteome analysis, we identified 55 potential systemic rejuvenating proteins produced by bone marrow-derived cells. For seven of these proteins, we were able to verify a rejuvenating effect on human skin cells using hallmarks of aging assays, supporting their role as systemic factors rejuvenating human skin tissue.
Privacy-preserving multicenter differential protein abundance analysis with FedProt
Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine; Barth, Teresa; Schweizer, Lisa; Giesbertz, Pieter; Schmidt, Johannes; Kalkhof, Stefan; Müller-Deile, Janina; van Veelen, Peter; Mohammed, Yassene; Hammer, Elke; Arend, Lis; Adamowicz, Klaudia; Laske, Tanja; Hartebrodt, Anne; Frisch, Tobias; Meng, Chen; Matschinske, Julian; Späth, Julian; Röttger, Richard; Schwämmle, Veit; Hauck, Stefanie; Lichtenthaler, Stefan; Imhof, Axel; Mann, Matthias; Ludwig, Christina; Kuster, Bernhard; Baumbach, Jan; Zolotareva, Olga (2025)
Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine...
Nature Computational Science 5 (8), 675–688.
DOI: 10.1038/s43588-025-00832-7
Placebo Interventions to Modulate Appetite: Sex-Specific Psychobiological and Cognitive Responses
Symposium "Exploring the World of Appetite: How Placebo and Nocebo Impact Hunger, Food Preferences, and Weight Changes" (Żegleń M, Meissner K, Schmidt L), 5th International Conference of the Society for Interdisciplinary Placebo Studies (SIPS), Krakau, Polen.
Peer Reviewed
Cardiological rehabilitation, prehabilitation, and cardiovascular prevention in adults with congenital heart defects: tasks and services of the German Pension Insurance-part 1: preventive cardiology and prehabilitation
Barth, J; Dewald, O; Ewert, Peter; Freiberger, Annika; Freilinger, Sebastian; Gampert, T; Harig, F; Hörer, J; Holdenrieder, S.; Huntgeburth, Michael; Kaemmerer-Suleiman, A; Kohls, Niko; Nagdyman, Nicole; Neidenbach, R,; Schmiedeberg, W; Suleiman, M; Von Scheidt, Fabian; Koch, D; Wagener, W; Mentzner, D; Kaemmerer, Harald; Mellert, F (2025)
Barth, J; Dewald, O; Ewert, Peter; Freiberger, Annika; Freilinger, Sebastian...
Cardiovasc Diagn Ther 15 (3), 684-695.
DOI: 10.21037/cdt-2024-691
Open Access Peer Reviewed
Cardiological rehabilitation, prehabilitation, and cardiovascular prevention in adults with congenital heart defects: tasks and services of the German Pension Insurance-part 2: cardiological rehabilitation
Barth, J; Dewald, O; Ewert, Peter; Freiberger, Annika; Freilinger, Sebastian; Gampert, T; Harig, F; Hörer, J; Holdenrieder, S.; Huntgeburth, Michael; Kaemmerer-Suleiman, A; Kohls, Niko; Nagdyman, Nicole; Neidenbach, R,; Schmiedeberg, W; Suleiman, M; Von Scheidt, Fabian; Koch, D; Wagener, W; Mentzner, D; Mellert, F; Kaemmerer, Harald (2025)
Barth, J; Dewald, O; Ewert, Peter; Freiberger, Annika; Freilinger, Sebastian...
Cardiovasc Diagn Ther 15 (3), 696-704.
DOI: 10.21037/cdt-2024-692
Open Access Peer Reviewed
Exploring the Role of Negative Expectations and Emotions in Primary Dysmenorrhea: Insights from a Case-Control Study
Thomann, Verena; Gomaa, Nadya; Stang, Marina; Funke, Susanne A.; Meißner, Karin (2025)
BMC Women's Health (25), 241.
Open Access Peer Reviewed
Traditional Chinese medicine for post-COVID: A retrospective cohort study
Kraft, Jana; Hardy, Anne; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina; Ziegler, Birgit; Waibl, Paula; Meißner, Karin (2025)
Kraft, Jana; Hardy, Anne; Baustädter, Verena; Bögel-Witt, Martina; Krassnig, Katharina...
Medicine 104 (18), e42275.
Open Access Peer Reviewed
Post-COVID syndrome affects at least 10% of individuals recovering from COVID-19. Currently, there is no causal treatment. This retrospective cohort study aimed to evaluate the potential of traditional Chinese medicine (TCM) in treating post-COVID symptoms. TCM physicians in Germany and Austria completed online questionnaires to retrospectively record symptoms, treatment approaches, and outcomes for patients diagnosed with post-COVID. Nine physicians collected data from 79 patients (65% female, 47 ± 16 SD). The most common TCM treatments for post-COVID were acupuncture (n = 66; 85%), Chinese pharmacological therapy (n = 61; 77%), and Chinese dietary counseling (n = 32; 41%). After an average of 7 ± 4 TCM consultations, physicians rated global symptom improvement as 62% ± 29%. Significant alleviation from the start of TCM treatment was observed in major symptoms, such as fatigue (P < .001), impaired physical performance (P < .001), and exertional dyspnea (P < .001). TCM treatment was associated with significant improvements in post-COVID symptoms, warranting further evaluation through randomized controlled studies.
Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension
Mattias, Francescapaola; Tsoy, Olga; Hammer, Elke; Gress, Alexander; Simm, Stefan; Lio, Chit; Ameling, Sabine; Amann, Kerstin; Dreher, Leonie; Wenzel, Ulrich; Kacprowski, Tim; List, Markus; Kalinina, Olga; Endlich, Karlhans; Baumbach, Jan; Völker, Uwe; Endlich, Nicole; Kliewe, Felix (2025)
Mattias, Francescapaola; Tsoy, Olga; Hammer, Elke; Gress, Alexander; Simm, Stefan...
J. Am. Soc. Nephrol. 36 (9), 1702–1715.
Open Access Peer Reviewed
BACKGROUND: Alterations in pre-mRNA splicing are crucial to the pathophysiology of various diseases. However, the effects of alternative splicing of mRNA on podocytes in hypertensive nephropathy are still unknown. The Sys_CARE project aimed to identify alternative splicing events involved in the development and progression of glomerular hypertension. METHODS: Murine podocytes were exposed to mechanical stretch, after which proteins and mRNA were analyzed by proteomics, RNA sequencing and several bioinformatic alternative splicing tools. RESULTS: Using transcriptomic and proteomic analysis, we identified significant changes in gene expression and protein abundance due to mechanical stretch. RNA-Seq identified over 3,000 alternative spliced genes after mechanical stretch, including all types of alternative splicing events. Among these, 17 genes exhibited an alternative splicing event across four different splicing analysis tools. From this group, we focused on Myl6, a component of the myosin protein complex, and Shroom3, an actin-binding protein essential for podocyte function. We identified two Shroom3 isoforms with significant expression changes under mechanical stretch, which was validated by qRT-PCR and in situ hybridization. Additionally, we observed an expression switch of two Myl6 isoforms after mechanical stretch, accompanied by an alteration in the C-terminal amino acid sequence. CONCLUSIONS: A comprehensive RNA-Seq analysis of mechanically stretched podocytes identified novel potential podocyte-specific biomarkers and highlighted significant alternative splicing events, notably in the mRNA of Shroom3 and Myl6.
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