Selection and characterization of Tau targeting D-peptides as a potential therapeutic approach for Alzheimer’s Disease
Aillaud, Isabelle; Malhis, Marwa; Kaniyappan, S.; Chandupatla, R.R.; Ramirez, L.-M.; Alkhashrom, Sewar ; Eichler, Jutta; Horn, A. H. C.; Zweckstetter , M.; Mandelkow, E.; Sticht, H.; Funke, Susanne A. (2023)
Aillaud, Isabelle; Malhis, Marwa; Kaniyappan, S.; Chandupatla, R.R.; Ramirez, L.-M....
AD/PD 2023 International Conference, Hybrid, 28.03.-01.04.2023.
The effects of pilates and open-label placebo on severe primary dysmenorrhea - a randomized controlled pilot study
Ort, Sandra; Waibl, Paula; Stang, Marina; Funke, Susanne A.; Dalkner, Nina; Meißner, Karin (2023)
Ort, Sandra; Waibl, Paula; Stang, Marina; Funke, Susanne A.; Dalkner, Nina...
Psychosomatic Medicine 85 (4), A28.
DOI: 10.1097/PSY.0000000000001202
Peer Reviewed
Ergebnisse der Mitgliederbefragungen der Ärztlichen und Offenen Schule der SMS im Frühjahr 2022
Waibl, Paula; Engelhardt, Ute; Nögel, Rainer; Hempen, Moritz; Meißner, Karin (2023)
Chinesische Medizin 38 (1), 30-39.
DOI: 10.1007/s00052-023-00074-8
Open Access
Taste matters: Mapping expectancy-based appetitive placebo effects onto the brain
Khalid, Iraj; Rodrigues, Belina; Dreyfus, Hippolyte; Frileux, Solene; Meißner, Karin; Fossati, Philippe; Hare, Todd Anthony; Schmidt, Liane (2023)
Khalid, Iraj; Rodrigues, Belina; Dreyfus, Hippolyte; Frileux, Solene; Meißner, Karin...
bioRxiv (Pre-print).
DOI: 10.1101/2023.02.14.527858
Open Access
Placebo in der Schmerzmedizin
Meißner, Karin (2023)
Vortrag auf der externen Schmerzkonferenz mit Qualitätszirkel 2023, Schön Klinik Bad Staffelstein / alphaMED Bamberg.
Alzheimer-Demenz – neue therapeutische Optionen?
Funke, Susanne A. (2023)
Lehrerfortbildung, Hochschule Coburg.
tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions
Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin; Mochmann, Liliana; Rad, Pegah; Weiss, Stefan; Simm, Stefan; Zeller, Tanja; Voelzke, Henry; Hoffmann, Wolfgang; Völker, Uwe; Felix, Stefan; Dörr, Marcus; Beling, Antje; Skurk, Carsten; Leistner, David-Manuel; Rauch, Bernhard; Hirose, Tetsuro; Heidecker, Bettina; Klingel, Karin; Nakagawa, Shinichi; Poller, Wolfram; Swirski, Filip; Haghikia, Arash; Poller, Wolfgang (2022)
Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin...
Cells 11 (24), 3970.
DOI: 10.3390/cells11243970
Open Access Peer Reviewed
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions have been assigned to the nuclear transcripts, data on biological functions of the small cytosolic transcripts are sparse. We previously found NEAT1-/- and MALAT1-/- mice to display massive atherosclerosis and vascular inflammation. Here, employing selective targeted disruption of menRNA or mascRNA, we investigate the tRNA-like molecules as critical components of innate immunity. CRISPR-generated human ΔmascRNA and ΔmenRNA monocytes/macrophages display defective innate immune sensing, loss of cytokine control, imbalance of growth/angiogenic factor expression impacting upon angiogenesis, and altered cell-cell interaction systems. Antiviral response, foam cell formation/oxLDL uptake, and M1/M2 polarization are defective in ΔmascRNA/ΔmenRNA macrophages, defining first biological functions of menRNA and describing new functions of mascRNA. menRNA and mascRNA represent novel components of innate immunity arising from the noncoding genome. They appear as prototypes of a new class of noncoding RNAs distinct from others (miRNAs, siRNAs) by biosynthetic pathway and intracellular kinetics. Their NEAT1-MALAT1 region of origin appears as archetype of a functionally highly integrated RNA processing system.
Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio; Bosch, Thomas; Wenck, Horst; Winnefeld, Marc; Grönniger, Elke; Simm, Stefan; Siracusa, Annette (2022)
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio...
The Journal of Investigative Dermatology 142 (12), 3136–3145.e11.
DOI: 10.1016/j.jid.2022.06.023
Open Access Peer Reviewed
Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and adequately respond to external stressors. Macrophages are important gatekeepers of tissue homeostasis, and it has been reported that their number and phenotype change during aging in a site-specific manner. How aging affects human skin macrophages and what implications this has for the aging process in the tissue are still not fully understood. Using single-cell RNA-sequencing analysis, we show that there is at least a 50% increase of macrophages in human aged skin, which appear to have developed from monocytes and exhibit more proinflammatory M1-like characteristics. In contrast, the cell-intrinsic ability of aged monocytes to differentiate into M1 macrophages was reduced. Using coculture experiments with aged dermal fibroblasts, we show that it is the aged microenvironment that drives a more proinflammatory phenotype of macrophages in the skin. This proinflammatory M1-like phenotype in turn negatively influenced the expression of extracellular matrix proteins by fibroblasts, emphasizing the impact of the aged macrophages on the skin phenotype.
Unspezifische Effekte von Operationen – Erkenntnisse aus der Placeboforschung
Meißner, Karin (2022)
Eingeladener Vortrag, Gründungsveranstaltung für das REGIOMED Zentrum für Wirbelsäulenmedizin, Regiomed Klinikum Lichtenfels .
Creditions in prevention and treatment: lessons learned from two empirical studies
Meißner, Karin (2022)
Vortrag auf der internationalen Tagung "The structure of creditions - methods, methodology, and assessment", Graz, Österreich.
A systematic review to evaluate the stress relieving potential of qigong, taiji and acupressure
Meißner, Karin (2022)
Oral presentation, 2022 Xing-lin International Week of Chengdu University of Traditional Chinese Medicine (CDUTCM).
Selection of Listeria monocytogenes InlA-Binding Peptides Using Phage Display—Novel Compounds for Diagnostic Applications?
Kenzel, Julia; Brüggemann, Dagmar Adeline; Funke, Susanne A. (2022)
Applied Microbiology 2022 (4), 2 | 921-933.
DOI: 10.3390/applmicrobiol2040070
Open Access
Placebo effects in medicine
Meißner, Karin (2022)
Vortrag im Rahmen der Vorlesungsreihe "Hot Topics in Psychology", TUM Fakultät für Sport- und Gesundheitswissenschaften.
Wie können IVF-Behandlungen weniger belastend gestaltet werden? Eine qualitative Studie zu den Erwartungen, Erfahrungen und Belastungen von Frauen mit wiederholt erfolglosen IVF-Behandlungen sollte Ansatzpunkte für Verbesserungen aufzeigen
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie; Olliges, Elisabeth; Kraft, Jana; Popovici, R. M.; Meißner, Karin (2022)
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie...
Frauenarzt - Offizielles Organ des Berufsverbands der Frauenärzte e.V. (BVF) sowie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. (DGGG) 63 (11), 722 – 726.
Placeboeffekte in der Medizin
Meißner, Karin (2022)
Chinesische Medizin 37 (3), 127–137.
DOI: 10.1007/s00052-022-00069-x
Open Access
Pain management with “eye movement desensitization and reprocessing” (EMDR): a pilot study to improve quality of life
Weiß, Katharina; Kohls, Niko (2022)
Prävention und Gesundheitsförderung.
DOI: 10.1007/s11553-022-00983-9
Open Access Peer Reviewed
Background
Effective pain management with long-lasting effects for patients with chronic pain is still a challenge.
Aim
Investigation of the effects of a health-promoting intervention with “eye movement desensitization and reprocessing” (EMDR) in patients with chronic pain and a possible improvement of their quality of life.
Method
Using a paper–pencil survey, 30 patients with chronic pain were interviewed at two timepoints using subscales of the German Pain Questionnaire (DSF), the Pain Disability Index (PDI), and the WHO Quality of Life—Short Version (WHOQOL-BREF). Between the two timepoints, the patients in the intervention group were treated with EMDR.
Results
Some significant results indicate that quality of life is improved by using EMDR to treat chronic pain. In the intervention group, quality of life improved significantly in the domains of physical, psychological, and global quality of life compared to both timepoints.
Conclusion
Due to the explorative character of this study, however, findings can only be cautiously interpreted, and long-term studies with larger samples and follow-up surveys should be conducted to clarify statements about the efficacy and long-term effects of EMDR treatment for chronic pain. This treatment method appears to be of great potential, and use of EMDR an integral part of a multimodal, interdisciplinary pain therapy seems promising.
Gesundheitscoaches in der Routineversorgung aus ärztlicher Sicht - eine qualitative Interviewstudie
Waibl, Paula; Rothenhäusler, Lena; Nöfer, Eberhard; Meißner, Karin (2022)
Vortrag, "Gesundheitsförderung in der post-pandemischen Phase", Jahrestagung des D|A|CH - Netzwerks für Gesundheitsförderung 2022, 16.-18. September in Hall in Tirol, Österreich.
Peer Reviewed
Application of the Community Readiness Model for childhood obesity prevention: a scoping review
Schröder, Maike; Schnabel, Monika; Hassel, Holger; Babitsch , Birgit (2022)
37 (4), 1-10.
DOI: 10.1093/heapro/daac120
Peer Reviewed
Tau Aggregation Inhibiting Peptides as Potential Therapeutics for Alzheimer Disease
Aillaud, Isabelle; Funke, Susanne A. (2022)
Cellular and Molecular Neurobiology 2022.
DOI: 10.1007/s10571-022-01230-7
Open Access Peer Reviewed
Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine; Geyer, Joachim; Simm, Stefan; Tzvetkov, Mladen (2022)
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine...
International Journal of Molecular Sciences 23 (9), 5100.
DOI: 10.3390/ijms23095100
Open Access Peer Reviewed
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing in six additional dog breeds. Next, dog OCT1 and OCT2 were stably overexpressed in HEK293 cells and the transport kinetics of five drugs were analyzed. We observed strong differences in the transport kinetics between dog and human orthologs. Dog OCT1 transported fenoterol with 12.9-fold higher capacity but 14.3-fold lower affinity (higher KM) than human OCT1. Human OCT1 transported ipratropium with 5.2-fold higher capacity but 8.4-fold lower affinity than dog OCT1. Compared to human OCT2, dog OCT2 showed 10-fold lower transport of fenoterol and butylscopolamine. In conclusion, the functional characterization of dog OCT1 and OCT2 reported here may have implications when using dogs as pre-clinical models as well as for drug therapy in dogs.
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