Mirror-image phage display for the selection of D-amino acid peptide ligands as potential therapeutics
Funke, Susanne A.; Malhis, Marwa (2024)
Current Protocolls 2024 (4), e957.
Open Access Peer Reviewed
Neues Verfahren zeigt Lockerung von Hüftgelenken im Mikrometerbereich
Reckter, Bettina (2024)
VDI nachrichten, 2024..
Künstliche Intelligenz: Trends, Gefahren und Chancen
Interview für Radio Plassenburg, Sendung Heimat ist..., 7.2.2024.
Biological nitrogen fixation, diversity and community structure of diazotrophs in two mosses in 25 temperate forests
Groß , C.; Hossen, Shakhawat; Dittrich, S.; Knorr, K.-H.; Borken , W.; Noll, Matthias (2024)
Groß , C.; Hossen, Shakhawat; Dittrich, S.; Knorr, K.-H.; Borken , W....
Environmental Microbiology 26, e16555.
DOI: 10.1111/1462-2920.16555
Open Access Peer Reviewed
Vorstellung des Forschungsprojekts AI4Coping
Meißner, Karin; Grubert, Jens (2024)
Interview im TV Oberfranken, Sendung 4you: Das neue Hochschulmagazin.
Open Access
Quelle: TV Oberfranken
Poultry litter biochar soil amendment affects microbial community structures, promotes phosphorus cycling and growth of barley (Hordeum vulgare).
Deinert, L.; Hossen, Shakhawat; Ikoyi, I.; Kwapinksi, W.; Noll, Matthias; Schmalenberger, Achim (2024)
Deinert, L.; Hossen, Shakhawat; Ikoyi, I.; Kwapinksi, W.; Noll, Matthias...
European Journal of Soil Biology 120, 103591.
DOI: 10.1016/j.ejsobi.2023.103591
Peer Reviewed
Active soil microbial composition and proliferation are directly affected by the presence of biocides from building materials
Kalkhof, Stefan; Reiß, Fabienne; Kiefer, Nadine; Purahong, Witoon; Borken , W.; Noll, Matthias (2024)
Kalkhof, Stefan; Reiß, Fabienne; Kiefer, Nadine; Purahong, Witoon; Borken , W....
Science of the Total Environment 912, 168689.
DOI: 10.1016/j.scitotenv.2023.168689
Peer Reviewed
Eluates from facades at the beginning of their service time affect aquatic and sediment organisms
Kalkhof, Stefan; Kiefer, Nadine; Nichterlein, Moritz; Reiß, Fabienne; Runge, M.; Biermann, U.; Wieland, Thomas; Noll, Matthias (2024)
Kalkhof, Stefan; Kiefer, Nadine; Nichterlein, Moritz; Reiß, Fabienne; Runge, M....
Science of the Total Environment. 906, 167531.
DOI: 10.1016/j.scitotenv.2023.167531
Peer Reviewed
Mapping expectancy-based appetitive placebo effects onto the brain in women
Khalid, Iraj ; Rodrigues, Belina ; Dreyfus, Hippolyte ; Frileux, Solène ; Meißner, Karin; Fossati, Philippe ; Hare, Todd Anthony ; Schmidt, Liane (2024)
Khalid, Iraj ; Rodrigues, Belina ; Dreyfus, Hippolyte ; Frileux, Solène ...
Nature Communications 15, 248 | 1-16.
DOI: 10.1038/s41467-023-44569-1
Open Access Peer Reviewed
Low dose ribosomal DNA P-loop mutation affects development and enforces autophagy in Arabidopsis
Shanmugam, Thiruvenkadam; Chaturvedi, Palak; Streit, Deniz; Ghatak, Arindam; Bergelt, Thorsten; Simm, Stefan; Weckwerth, Wolfram; Schleiff, Enrico (2024)
Shanmugam, Thiruvenkadam; Chaturvedi, Palak; Streit, Deniz; Ghatak, Arindam...
RNA biology 21 (1), 1–15.
DOI: 10.1080/15476286.2023.2298532
Open Access Peer Reviewed
Arabidopsis contains hundreds of ribosomal DNA copies organized within the nucleolar organizing regions (NORs) in chromosomes 2 and 4. There are four major types of variants of rDNA, VAR1-4, based on the polymorphisms of 3’ external transcribed sequences. The variants are known to be differentially expressed during plant development. We created a mutant by the CRISPR-Cas9-mediated excision of ~ 25 nt from predominantly NOR4 ribosomal DNA copies, obtaining mosaic mutational events on ~ 5% of all rDNA copies. The excised region consists of P-loop and Helix-82 segments of 25S rRNA. The mutation led to allelic, dosage-dependent defects marked by lateral root inhibition, reduced size, and pointy leaves, all previously observed for defective ribosomal function. The mutation in NOR4 led to dosage compensation from the NOR2 copies by elevated expression of VAR1 in mutants and further associated single-nucleotide variants, thus, resulting in altered rRNA sub-population. Furthermore, the mutants exhibited rRNA maturation defects specifically in the minor pathway typified by 32S pre-rRNA accumulation. Density-gradient fractionation and subsequent RT-PCR of rRNA analyses revealed that mutated copies were not incorporated into the translating ribosomes. The mutants in addition displayed an elevated autophagic flux as shown by the autophagic marker GFP-ATG8e, likely related to ribophagy.
Leadership as a Mental Shield: How Leaders of Specialised Police Units Can Promote Inner Resilience and Mental Stability.
Jäger, Tamara; Giordano, J.; Kohls, Niko (2023)
, 401-425.
Peer Reviewed
Guided Acoustic Waves in Polymer Rods with Varying Immersion Depth in Liquid
Lutter, Klaus; Backer, Alexander; Drese, Klaus Stefan (2023)
Sensors 2023 (23), 9892.
DOI: 10.3390/s23249892
Open Access Peer Reviewed
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS-Like Zebrafish Model
Schindler, Maximilian; Siegerist, Florian; Lange, Tim; Simm, Stefan; Bach, Sophia-Marie; Klawitter, Marianne; Gehrig, Jochen; Gul, Sheraz; Endlich, Nicole (2023)
Schindler, Maximilian; Siegerist, Florian; Lange, Tim; Simm, Stefan; Bach, Sophia-Marie...
Journal of the American Society of Nephrology: JASN 34 (12), 1977–1990.
DOI: 10.1681/ASN.0000000000000235
Open Access Peer Reviewed
BACKGROUND: FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss of filtration barrier function and the development of sclerotic lesions. Therapies to treat FSGS are limited, and podocyte-specific drugs are unavailable. To address the need for treatments to delay or stop FSGS progression, researchers are exploring the repurposing of drugs that have been approved by the US Food and Drug Administration (FDA) for other purposes. METHODS: To identify drugs with potential to treat FSGS, we used a specific zebrafish screening strain to combine a high-content screening (HCS) approach with an in vivo model. This zebrafish screening strain expresses nitroreductase and the red fluorescent protein mCherry exclusively in podocytes (providing an indicator for podocyte depletion), as well as a circulating 78 kDa vitamin D-binding enhanced green fluorescent protein fusion protein (as a readout for proteinuria). To produce FSGS-like lesions in the zebrafish, we added 80 µ M metronidazole into the fish water. We used a specific screening microscope in conjunction with advanced image analysis methods to screen a library of 138 drugs and compounds (including some FDA-approved drugs) for podocyte-protective effects. Promising candidates were validated to be suitable for translational studies. RESULTS: After establishing this novel in vivo HCS assay, we identified seven drugs or compounds that were protective in our FSGS-like model. Validation experiments confirmed that the FDA-approved drug belinostat was protective against larval FSGS. Similar pan-histone deacetylase inhibitors also showed potential to reproduce this effect. CONCLUSIONS: Using an FSGS-like zebrafish model, we developed a novel in vivo HCS assay that identified belinostat and related pan-histone deacetylase inhibitors as potential candidates for treating FSGS.
Evaluation of crowdsourced mortality prediction models as a framework for assessing artificial intelligence in medicine
Bergquist, Timothy; Schaffter, Thomas; Yan, Yao; Yu, Thomas; Prosser, Justin; Gao, Jifan; Chen, Guanhua; Charzewski, Łukasz; Nawalany, Zofia; Brugere, Ivan; Retkute, Renata; Prusokas, Alidivinas; Prusokas, Augustinas; Choi, Yonghwa; Lee, Sanghoon; Choe, Junseok; Lee, Inggeol; Kim, Sunkyu; Kang, Jaewoo; Mooney, Sean; Guinney, Justin; Consortium, Patient (2023)
Bergquist, Timothy; Schaffter, Thomas; Yan, Yao; Yu, Thomas; Prosser, Justin...
Journal of the American Medical Informatics Association: JAMIA 31 (1), 35–44.
DOI: 10.1093/jamia/ocad159
Open Access Peer Reviewed
OBJECTIVE: Applications of machine learning in healthcare are of high interest and have the potential to improve patient care. Yet, the real-world accuracy of these models in clinical practice and on different patient subpopulations remains unclear. To address these important questions, we hosted a community challenge to evaluate methods that predict healthcare outcomes. We focused on the prediction of all-cause mortality as the community challenge question. MATERIALS AND METHODS: Using a Model-to-Data framework, 345 registered participants, coalescing into 25 independent teams, spread over 3 continents and 10 countries, generated 25 accurate models all trained on a dataset of over 1.1 million patients and evaluated on patients prospectively collected over a 1-year observation of a large health system. RESULTS: The top performing team achieved a final area under the receiver operator curve of 0.947 (95% CI, 0.942-0.951) and an area under the precision-recall curve of 0.487 (95% CI, 0.458-0.499) on a prospectively collected patient cohort. DISCUSSION: Post hoc analysis after the challenge revealed that models differ in accuracy on subpopulations, delineated by race or gender, even when they are trained on the same data. CONCLUSION: This is the largest community challenge focused on the evaluation of state-of-the-art machine learning methods in a healthcare system performed to date, revealing both opportunities and pitfalls of clinical AI.
Cuticular microbiome composition of Osmia bicornis is different to Apis mellifera honeybees
Thamm, M.; Reiß, Fabienne; Sohl, Leon; Gabel, M.; Noll, Matthias; Scheiner, Ricarda (2023)
MDPI microorganisms 11, 2780.
DOI: 10.3390/microorganisms11112780
Open Access Peer Reviewed
Fachgespräch: Selbst- und Fremdführung durch Achtsamkeit und die Ausbildung von Resilienz. Online-Workshop für das Bayrische Landesamt für Pflege, Ansbach, 22.11.2023
Kohls, Niko (2023)
Achtsamkeit und Nachhaltigkeit: Eine wissenschaftliche Perspektive. Vortag im Rahmen der Climate School, Hochschule Coburg.
Kohls, Niko (2023)
Achtsamkeit und Resilienz: gesund und erfüllt im Lehrerberuf – geht das? Keynote 15. Lehrergesundheitstag Gesunderhaltung im Lehrerberuf – analog und digital, Hochschule Hof, 16.11.2023.
Kohls, Niko (2023)
Sinn & Kohärenz: Die Psychologie als Lehre von Erleben und Verhalten zwischen Theorie und Empirie.
Kohls, Niko (2023)
Placebo responses and effects: Processes, potential, and ethical considerations in clinical care
Kohls, Niko; Leyva, Monica A.; Giordano, James (2023)
Placebo Effects Through the Lens of Translational Research 2023, 251 - 266.
DOI: 10.1093/med/9780197645444.003.0019
Open Access Peer Reviewed
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de