Effects of self-compassion and self-forgiveness on functional disability in chronic pain: Exploring stress, depression, and sleep as mediators
Altier, H.; Meek, R.; Toussaint, L.; Kohls, Niko; Hanshans, Christian ; Sirois, F.; Untner, J.; Hölzl, B.; Gaisberger, M.; Offenbaecher, M.; Hirsch, J. K. (2019)
Altier, H.; Meek, R.; Toussaint, L.; Kohls, Niko; Hanshans, Christian ; Sirois, F....
Oral presentation at the 66th Annual Convention of the Tennessee Psychological Association, Nashville, Tennessee.
Peer Reviewed
The intracellular distribution of the components of the GET system in vascular plants
Bodensohn, Uwe; Simm, Stefan; Fischer, Ken; Jäschke, Michelle; Groß, Lucia; Kramer, Katharina; Ehmann, Christian; Rensing, Stefan; Ladig, Roman; Schleiff, Enrico (2019)
Bodensohn, Uwe; Simm, Stefan; Fischer, Ken; Jäschke, Michelle; Groß, Lucia...
Biochimica Et Biophysica Acta. Molecular Cell Research 1866 (10), 1650–1662.
DOI: 10.1016/j.bbamcr.2019.06.012
Open Access Peer Reviewed
The guided entry of tail-anchored proteins (GET) pathway facilitates targeting and insertion of tail-anchored proteins into membranes. In plants, such a protein insertion machinery for the endoplasmic reticulum as well as constituents within mitochondrial and chloroplasts were discovered. Previous phylogenetic analysis revealed that Get3 sequences of Embryophyta form two clades representing cytosolic ("a") and organellar ("bc") GET3 homologs, respectively. Cellular fractionation of Arabidopsis thaliana seedlings and usage of the self-assembly GFP system in protoplasts verified the cytosolic (ATGet3a), plastidic (ATGet3b) and mitochondrial (ATGet3c) localization of the different homologs. The identified plant homologs of Get1 and Get4 in A. thaliana are localized in ER and cytosol, respectively, implicating a degree of conservation of the GET pathway in A. thaliana. Transient expression of Get3 homologs of Solanum lycopersicum, Medicago × varia or Physcomitrella patens with the self-assembly GFP technique in homologous and heterologous systems verified that multiple Get3 homologs with differing subcellular localizations are common in plants. Chloroplast localized Get3 homologs were detected in all tested plant systems. In contrast, mitochondrial localized Get3 homologs were not identified in S. lycopersicum, or P. patens, while we confirmed on the example of A. thaliana proteins that mitochondrial localized Get3 proteins are properly targeted in S. lycopersicum as well.
Characterization of aluminium oxid layers with a laser ultrasonic setup using the dispersion of Rayleigh waves
Brand, Felix; Singer, Ferdinand; Drese, Klaus Stefan (2019)
LUS4Metals. Linz, .
Health beliefs, attitudes, and health-related quality of life in persons with fibromyalgia: mediating role of treatment adherence
Rowe, C.; Sirios , F. ; Toussaint, L.; Kohls, Niko; Nöfer, Eberhard; Offenbacher, M.; Hirsch, J. K. (2019)
Rowe, C.; Sirios , F. ; Toussaint, L.; Kohls, Niko; Nöfer, Eberhard; Offenbacher, M....
Psychology, Health & Medicine, 24(8), 962-977. Retrieved from https://doi.org/10.1080/13548506.2019.1576913. doi:10.1080/13548506.2019.1576913, 962-977.
DOI: 10.1080/13548506.2019.1576913
Peer Reviewed
Challenges and Criticisms in the Field of Spirituality, Religiousness, and Health
Walach, H.; Kohls, Niko (2019)
In G. Lucchetti, M. F. Prieto Peres, & R. F. Damiano (Eds.), Spirituality, Religiousness and Health: From Research to Clinical Practice (pp. 33-48)., 33-48.
Das Quartier als Setting zur Förderung sozialer Integration und Gesundheitskompetenz: das kommunale Gesundheitsförderungsprojekt „Gesunde Südstadt“
Röhrich, Christina; Karl, V.; Pfeifer, G.; John, Dennis; Kohls, Niko (2019)
Das Gesundheitswesen, 81(08/09), 712-712. doi:10.1055/s-0039-1694507.
DOI: doi:10.1055/s-0039-1694507
Peer Reviewed
Functional diversification of tomato HsfA1 factors is based on DNA binding domain properties
El-Shershaby, Asmaa; Ullrich, Sarah; Simm, Stefan; Scharf, Klaus-Dieter; Schleiff, Enrico; Fragkostefanakis, Sotirios (2019)
El-Shershaby, Asmaa; Ullrich, Sarah; Simm, Stefan; Scharf, Klaus-Dieter...
Gene 714, 143985.
DOI: 10.1016/j.gene.2019.143985
Open Access Peer Reviewed
In all eukaryotes, the response to heat stress (HS) is dependent on the activity of HS transcription factors (Hsfs). Plants contain a large number of Hsfs, however, only members of the HsfA1 subfamily are considered as master regulators of stress response and thermotolerance. In Solanum lycopersicum, among the four HsfA1 members, only HsfA1a has been proposed to possess a master regulator function. We performed a comparative analysis of HsfA1a, HsfA1b, HsfA1c and HsfA1e at different levels of regulation and function. HsfA1a is constitutively expressed under control and stress conditions, while the other members are induced in specific tissues and stages of HS response. Despite that all members are localized in the nucleus when expressed in protoplasts, only HsfA1a shows a wide range of basal activity on several HS-induced genes. In contrast, HsfA1b, HsfA1c, and HsfA1e show only high activity for specific subsets of genes. Domain swapping mutants between HsfA1a and HsfA1c revealed that the variation in that transcriptional transactivation activity is due to differences in the DNA binding domain (DBD). Specifically, we identified a conserved arginine (R107) residue in the turn of β3 and β4 sheet in the C-terminus of the DBD of HsfA1a that is highly conserved in plant HsfA1 proteins, but is replaced by leucine and cysteine in tomato HsfA1c and HsfA1e, respectively. Although not directly involved in DNA interaction, R107 contributes to DNA binding and consequently the activity of HsfA1a. Thus, we demonstrate that this variation in DBD in part explains the functional diversification of tomato HsfA1 members.
Mindfulness Meditation and Fantasy Relaxation in a Group Setting Leads to a Diminished Sense of Self and an Increased Present Orientation
Kohls, Niko; Esch, Tobias; Gerber, L.; Adrian, L.; Wittmann, M. (2019)
Behavioral Sciences, 9(8), 87. Retrieved from https://www.mdpi.com/2076-328X/9/8/87 .
Peer Reviewed
Co-orthologues of ribosome biogenesis factors in A. thaliana are differentially regulated by transcription factors
Kovacevic, Jelena; Palm, Denise; Jooss, Domink; Bublak, Daniela; Simm, Stefan; Schleiff, Enrico (2019)
Kovacevic, Jelena; Palm, Denise; Jooss, Domink; Bublak, Daniela; Simm, Stefan...
Plant Cell Reports 38 (8), 937–949.
DOI: 10.1007/s00299-019-02416-y
Open Access Peer Reviewed
Different genes coding for one ribosome biogenesis factor are differentially expressed and are likely under the control of distinct transcription factors, which contributes to the regulatory space for ribosome maturation. Maturation of ribosomes including rRNA processing and modification, rRNA folding and ribosome protein association requires the function of many ribosome biogenesis factors (RBFs). Recent studies document plant-specific variations of the generally conserved process of ribosome biogenesis. For instance, distinct rRNA maturation pathways and intermediates have been identified, the existence of plant specific RBFs has been proposed and several RBFs are encoded by multiple genes. The latter in combination with the discussed ribosome heterogeneity points to a possible function of the different proteins representing one RBF in diversification of ribosomal compositions. Such factor-based regulation would require a differential regulation of their expression, may be even controlled by different transcription factors. We analyzed the expression profiles of genes coding for putative RBFs and transcription factors. Most of the genes coding for RBFs are expressed in a comparable manner, while different genes coding for a single RBF are often differentially expressed. Based on a selected set of genes we document a function of the transcription factors AtMYC1, AtMYC2, AtbHLH105 and AtMYB26 on the regulation of different RBFs. Moreover, on the example of the RBFs LSG1 and BRX1, both encoded by two genes, we give a first hint on a differential transcription factor dependence of expression. Consistent with this observation, the phenotypic analysis of RBF mutants suggests a relation between LSG1-1 and BRX1-1 expression and the transcription factor MYC1. In summary, we propose that the multiple genes coding for one RBF are required to enlarge the regulatory space for ribosome biogenesis.
Bewusstsein für Prävention und Gesundheitsförderung – Bedeutung für die Behandlung chronischer Erkrankungen
Röhrich, Christina; Kohls, Niko (2019)
Zeitschrift Herzblick – Das Merlin-AHF Projekt, Herausgeber Herzkind e. V. Sonderausgabe 3/2019.
Perceived stigma and health-related quality of life in the working uninsured: Does thwarted belongingness play a role? Stigma and Health, 4(1), 1-10.
Hirsch, J. K.; Sirios , F. ; Visser, P.; Brooks, B.; Kohls, Niko; Offenbacher, M.; Toussaint, L. (2019)
Hirsch, J. K.; Sirios , F. ; Visser, P.; Brooks, B.; Kohls, Niko; Offenbacher, M....
Perceived stigma and health-related quality of life in the working uninsured: Does thwarted belongingness play a role? Stigma and Health..
Open Access Peer Reviewed
FRI0693 Resilience traits in a large cohort of patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA) and fibromyalgia (FM)
Toussaint, L.; Kohls, Niko; Hanshans, C.; Vallejo, M.; Rivera, J.; Sirois, F.; Hirsch, J. K.; Untner, J.; Hölzl, B.; Gaisberger, M.; Offenbächer, M. (2019)
Toussaint, L.; Kohls, Niko; Hanshans, C.; Vallejo, M.; Rivera, J.; Sirois, F....
Annals of the Rheumatic Diseases, 78(Suppl 2), 1046-1046. Retrieved from https://ard.bmj.com/content/annrheumdis/78/Suppl_2/1046.1.full.pdf. doi:10.1136/annrheumdis-2019-eular.5361 .
Peer Reviewed
FRI0694 Self-reported sleeping problems and fatigue in large cohort of patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA) and fibromyalgia (FM)
Offenbächer, M.; Kohls, Niko; Hanshans, Christian ; Vallejo, M.; Rivera, J.; Sirios , F. ; Hirsch, J. K.; Untner, J.; Hölzl, B.; Gaisberger, M.; Toussaint, L. (2019)
Offenbächer, M.; Kohls, Niko; Hanshans, Christian ; Vallejo, M.; Rivera, J....
Annals of the Rheumatic Diseases, 78(Suppl 2), 1046-1046. Retrieved from https://ard.bmj.com/content/annrheumdis/78/Suppl_2/1046.2.full.pdf. doi:10.1136/annrheumdis-2019-eular.4912.
Open Access Peer Reviewed
Sicherheit statt Freiheit?! - Einsatz freiheitsentziehender Maßnahmen (FEM) in der Pflege von Menschen mit Demenz
Berzlanovich, A.; Kohls, Niko (2019)
In H. Walach & M. Loef (Eds.), Demenz – Prävention und Therapie (pp. 439 - 448). Essen: KVC., 439-448.
SAT0680 Educational needs of a large cohort of patients with different rheumatic and musculoskeletal diseases attending a health facility in Austria
Offenbaecher, M.; Toussaint, L.; Kohls, Niko; Hanshans, Christian ; Vallejo, M.; Rivera, J.; Sirios , F. ; Hirsch, J. K.; Untner, J.; Hölzl, B.; Gaisberger, M.; Ndosi, M. (2019)
Offenbaecher, M.; Toussaint, L.; Kohls, Niko; Hanshans, Christian ; Vallejo, M....
Annals of the Rheumatic Diseases 2019 / 78, 1442.
Peer Reviewed
Stress im Studium
Nagel, Andreas; John, Dennis; Kohls, Niko (2019)
Moment by Moment..
Bedeutung von Prävention, Gesundheitsförderung und die Rolle des salutogenetischen Denkens in der Behandlung von chronischen Erkrankungen
Röhrich, Christina; Kohls, Niko (2019)
Journal für angeborene Herzfehler, Band 7 7.
Regulation of two GTPases Toc159 and Toc34 in the translocon of the outer envelope of chloroplasts
Wiesemann, Katharina; Simm, Stefan; Mirus, Oliver; Ladig, Roman; Schleiff, Enrico (2019)
Biochimica Et Biophysica Acta. Proteins and Proteomics 1867 (6), 627–636.
DOI: 10.1016/j.bbapap.2019.01.002
Open Access Peer Reviewed
The GTPases Toc159 and Toc34 of the translocon of the outer envelope of chloroplasts (TOC) are involved in recognition and transfer of precursor proteins at the cytosolic face of the organelle. Both proteins engage multiple interactions within the translocon during the translocation process, including dimeric states of their G-domains. The units of the Toc34 homodimer are involved in the recognition of the transit peptide representing the translocation signal of precursor proteins. This substrate recognition is part of the regulation of the GTPase cycle of Toc34. The Toc159 monomer and the Toc34 homodimer recognize the transit peptide of the small subunit of Rubisco at the N- and at the C-terminal region, respectively. Analysis of the transit peptide interaction by crosslinking shows that the heterodimer between both G-domains binds pSSU most efficiently. While substrate recognition by Toc34 homodimer was shown to regulate nucleotide exchange, we provide evidence that the high activation energy of the GTPase Toc159 is lowered by substrate recognition. The nucleotide affinity of Toc34G homodimer and Toc159G monomer are distinct, Toc34G homodimer recognizes GDP and Toc159G GTP with highest affinity. Moreover, the analysis of the nucleotide association rates of the monomeric and dimeric receptor units suggests that the heterodimer has an arrangement distinct from the homodimer of Toc34. Based on the biochemical parameters determined we propose a model for the order of events at the cytosolic side of TOC. The molecular processes described by this hypothesis range from transit peptide recognition to perception of the substrate by the translocation channel.
Mindful Leader Development: How Leaders Experience the Effects of Mindfulness Training on Leader Capabilities
Rupprecht, S.; Falke, P.; Kohls, Niko; Tamdjidi, C.; Wittmann, M.; Kersemaekers, W. (2019)
Frontiers in Psychology, 10(1081). doi:10.3389/fpsyg.2019.01081.
DOI: 10.3389/fpsyg.2019.01081
Peer Reviewed
Von der Psychologie des Horizontes zu den epistemologischen Horizonten der akademischen Psychologie
Kohls, Niko (2019)
In B. Frischmann & C. Holtorf (Eds.), Über den Horizont - Standorte, Grenzen und Perspektiven (pp. 149 - 164): De Gruyter., 149-164.
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de