Buchholz-Schuster, Eckardt (2014)
Zeitschrift der Savigny-Stiftung für Rechtsgeschichte, Germanistische Abteilung 2014/ Bd. 131, 560 ff..
DOI: 10.7767/zrgga-2014-0147
Schaub, Michael (2014)
Masterarbeit, Hochschule Biberach, 2014.
Martin, Roman; Hackert, Philipp; Ruprecht, Maike; Simm, Stefan; Brüning, Lukas; Mirus, Oliver; Sloan, Katherine; Kudla, Grzegorz; Schleiff, Enrico; Bohnsack, Markus (2014)
Martin, Roman; Hackert, Philipp; Ruprecht, Maike; Simm, Stefan; Brüning, Lukas...
RNA (New York, N.Y.) 20 (8), 1173–1182.
DOI: 10.1261/rna.044669.114
Ribosome biogenesis in yeast requires 75 small nucleolar RNAs (snoRNAs) and a myriad of cofactors for processing, modification, and folding of the ribosomal RNAs (rRNAs). For the 19 RNA helicases implicated in ribosome synthesis, their sites of action and molecular functions have largely remained unknown. Here, we have used UV cross-linking and analysis of cDNA (CRAC) to reveal the pre-rRNA binding sites of the RNA helicase Rok1, which is involved in early small subunit biogenesis. Several contact sites were identified in the 18S rRNA sequence, which interestingly all cluster in the "foot" region of the small ribosomal subunit. These include a major binding site in the eukaryotic expansion segment ES6, where Rok1 is required for release of the snR30 snoRNA. Rok1 directly contacts snR30 and other snoRNAs required for pre-rRNA processing. Using cross-linking, ligation and sequencing of hybrids (CLASH) we identified several novel pre-rRNA base-pairing sites for the snoRNAs snR30, snR10, U3, and U14, which cluster in the expansion segments of the 18S rRNA. Our data suggest that these snoRNAs bridge interactions between the expansion segments, thereby forming an extensive interaction network that likely promotes pre-rRNA maturation and folding in early pre-ribosomal complexes and establishes long-range rRNA interactions during ribosome synthesis.
Wittmann, M.; Peter, J.; Gutina, O.; Otten, S.; Kohls, Niko; Meißner, Karin (2014)
Personality and Individual Differences, 64(0), 41-45. , 41-45.
Berzlanovich, A.; Kirsch, S.; Herold-Majumdar, A.; Randzio, O; Kohls, Niko (2014)
In T. Gaertner, B. Gansweid, H. Gerber, F. Schwegler, & U. Heine (Eds.), Die Pflegeversicherung: Handbuch zur Begutachtung, Qualitätsprüfung, Beratung und Fortbildung (3 ed., pp. 462-470). Berlin: Walter de Gruyter., 462-470.
Offenbacher, M.; Herold-Majumdar, Astrid; Frauenhofer, Andreas; Thomas, Lisa; Roletscheck, Heike; Kohls, Niko; Bührlen, Brigitte (2014)
Offenbacher, M.; Herold-Majumdar, Astrid; Frauenhofer, Andreas; Thomas, Lisa...
Lage: Jacobs Verlag 2014..
Kaltwasser, V.; Sauer, S.; Kohls, Niko (2014)
In S. Schmidt & H. Walach (Eds.), Meditation – Neuroscientific Approaches and Philosophical Implications (Vol. 2, pp. 381-404): Springer International Publishing., 381-404.
Heinrich, Michael (2014)
Vortrag und Proceedings, 5th Annual International Conference on Visual and Performing Arts, Athens Institute for Education and Research, 2014.
Sundberg, Tobias; Petzold, M.; Kohls, Niko; Falkenberg, T. (2014)
PLoS ONE, 9(5). .
Cmyrev , A. ; Reißing, Ralf (2014)
ESIT 2014, April 2014, Krabi. .
Jurkat, H.; Christina, U.; V., Anke; Janosch,, R.; Sauer, S.; Ott, U.; Büssing, Arndt; Kohls, Niko (2014)
Jurkat, H.; Christina, U.; V., Anke; Janosch,, R.; Sauer, S.; Ott, U.; Büssing, Arndt...
Paper presented at the Deutscher Kongress für Psychosomatische Medizin und Psychotherapie Berlin, 26 – 29.3.2014..
Esch, Tobias; Offenbächer, M.; Kohls, Niko (2014)
In P. Angerer, J. Glaser, H. Gündel, P. Henningsen, C. Lahmann, S. Letzel & D. Nowak (Eds.), Psychische und psychosomatische Gesundheit in der Arbeit (pp. 261 - 268). Landsberg: Ecomed., 261-268.
Geelhaar, Jens; Markert, Michael; Deich, Johannes; Schied, Martin (2014)
Proceedings of the 8th International Conference on Tangible, Embedded and Embodied Interaction 2014, 365-368.
DOI: 10.1145/2540930.2567900
Ebersberger, Ingo; Simm, Stefan; Leisegang, Matthias; Schmitzberger, Peter; Mirus, Oliver; von Haeseler, Arndt; Bohnsack, Markus; Schleiff, Enrico (2014)
Ebersberger, Ingo; Simm, Stefan; Leisegang, Matthias; Schmitzberger, Peter...
Nucleic Acids Research 42 (3), 1509–1523.
DOI: 10.1093/nar/gkt1137
Ribosome biogenesis is fundamental for cellular life, but surprisingly little is known about the underlying pathway. In eukaryotes a comprehensive collection of experimentally verified ribosome biogenesis factors (RBFs) exists only for Saccharomyces cerevisiae. Far less is known for other fungi, animals or plants, and insights are even more limited for archaea. Starting from 255 yeast RBFs, we integrated ortholog searches, domain architecture comparisons and, in part, manual curation to investigate the inventories of RBF candidates in 261 eukaryotes, 26 archaea and 57 bacteria. The resulting phylogenetic profiles reveal the evolutionary ancestry of the yeast pathway. The oldest core comprising 20 RBF lineages dates back to the last universal common ancestor, while the youngest 20 factors are confined to the Saccharomycotina. On this basis, we outline similarities and differences of ribosome biogenesis across contemporary species. Archaea, so far a rather uncharted domain, possess 38 well-supported RBF candidates of which some are known to form functional sub-complexes in yeast. This provides initial evidence that ribosome biogenesis in eukaryotes and archaea follows similar principles. Within eukaryotes, RBF repertoires vary considerably. A comparison of yeast and human reveals that lineage-specific adaptation via RBF exclusion and addition characterizes the evolution of this ancient pathway.
Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A.; Willbold, Dieter; Schaal , Heiner (2014)
Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A....
AIDS Research and Therapy 11, 1.
DOI: 10.1186/1742-6405-11-1
Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr; Nagel-Steger, Luitgard; Funke, Susanne A.; Willbold, Dieter; Strodel , B. (2014)
Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr...
National Library of Medicine
National Center for Biotechnology Information, 1448-57.
DOI: 10.2174/0929867321666131129122247
Wilde, Mathias (2014)
Raumforschung und Raumordnung 72 (5), 371-384.
DOI: 10.1007/s13147-014-0301-z
Wilde, Mathias (2014)
RaumPlanung (3), 61-64.
Wilde, Mathias (2014)
25.
DOI: 10.1007/978-3-658-03819-9
Exner, Dagmar; Lucchi, Elena; Troi, Alexandra; Freundorfer, Franz; Andrè, Mathilde; Kofler Engl, Waltraud (2014)
Exner, Dagmar; Lucchi, Elena; Troi, Alexandra; Freundorfer, Franz; Andrè, Mathilde...
Proceedings of the 18th international Passive House Conference, Aachen.
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg