40S ribosome biogenesis co-factors are essential for gametophyte and embryo development
Missbach, Sandra; Weis, Benjamin; Martin, Roman; Simm, Stefan; Bohnsack, Markus; Schleiff, Enrico (2013)
Missbach, Sandra; Weis, Benjamin; Martin, Roman; Simm, Stefan; Bohnsack, Markus...
PloS One 8 (1), e54084.
DOI: 10.1371/journal.pone.0054084
Open Access Peer Reviewed
Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in Arabidopsis thaliana, namely Rrp5, Pwp2, Nob1, Enp1 and Noc4. The characterization of the proteins in respect to localization, enzymatic activity and association with pre-ribosomal complexes is shown. Additionally, analyses of T-DNA insertion mutants aimed to reveal an involvement of the plant co-factors in ribosome biogenesis. The investigated proteins localize mainly to the nucleolus or the nucleus, and atEnp1 and atNob1 co-migrate with 40S pre-ribosomal complexes. The analysis of T-DNA insertion lines revealed that all proteins are essential in Arabidopsis thaliana and mutant plants show alterations of rRNA intermediate abundance already in the heterozygous state. The most significant alteration was observed in the NOB1 T-DNA insertion line where the P-A3 fragment, a 23S-like rRNA precursor, accumulated. The transmission of the T-DNA through the male and female gametophyte was strongly inhibited indicating a high importance of ribosome co-factor genes in the haploid stages of plant development. Additionally impaired embryogenesis was observed in some mutant plant lines. All results support an involvement of the analyzed proteins in ribosome biogenesis but differences in rRNA processing, gametophyte and embryo development suggested an alternative regulation in plants.
Freiheitsentziehende Maßnahmen in der Pflege – Wo ist die Grenze zwischen Fürsorge und Übergriff?
Berzlanovich, A.; Kirsch, S.; Schöpfer, J.; Keil, W; Kohls, Niko (2012)
MMW - Fortschritte der Medizin, 154(20), 53-55, 53-55.
Gerichtliche Genehmigungspraxis und pflegewissenschaftlicher Ansatz bei freiheitsentziehenden Maßnahmen - ein Widerspruch?
Berzlanovich, A.; Kirsch, L.; Kohls, Niko (2012)
Betreuungsrechtliche Praxis (3), 95 - 99., 95 - 99.
Peer Reviewed
Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy
Sun, Na; Hartmann, Rudolf ; Lecher, Justin ; Stoldt , Matthias ; Funke, Susanne A.; Gremer, Lothar; Ludwig , Hans-Henning ; Demuth, Hans-Ulrich; Kleinschmidt , Martin ; Willbold, Dieter (2012)
Sun, Na; Hartmann, Rudolf ; Lecher, Justin ; Stoldt , Matthias ; Funke, Susanne A....
J Pept Sci
2012 Nov;18(11):691-5 2012, 18.
DOI: 10.1002/psc.2456
Open Access Peer Reviewed
Mirror image phage display--generating stable therapeutically and diagnostically active peptides with biotechnological means
Sun, Na; Funke, Susanne A.; Willbold, Dieter (2012)
J Biotechnol 161, 2.
DOI: 10.1016/j.jbiotec.2012.05.019
Open Access Peer Reviewed
Quality of life in patients with fibromyalgia: validation and psychometric properties of the German Quality of Life Scale (QOLS-G)
Offenbächer, M.; Sauer, S.; Kohls, Niko; Waltz, M.; Schoeps, P. (2012)
Rheumatology International, 32(10), 3243-3252, 3243-3252.
Peer Reviewed
Durchgängiges Variantenmanagement auf Basis eines Merkmalmodells für effizientes Testen hochvariabler Systeme
Cmyrev , A. ; Nörenberg , R.; Hopp, D.; Reißing, Ralf (2012)
4. Autotest, Oktober 2012, Stuttgart.
Specific Objectivity of Mindfulness—A Rasch Analysis of the Freiburg Mindfulness Inventory
Sauer, S.; Ziegler, M.; Danay, E; M., Ives, , J.; Kohls, Niko (2012)
Mindfulness, 4(1), 45-54., 45-54.
Peer Reviewed
Consistency Checking of Feature Mapping between Requirements and Test Artefacts
Cmyrev , A. ; Nörenberg , R.; Hopp, D.; Reißing, Ralf (2012)
19th ISPE International Conference on Concurrent Engineering (CE2012), September 2012, Trier.
Peer Reviewed
The evaluation of etoricoxib as a preemptive and postoperative analgetic in a randomised controlled trial in 103 patients with laparotomy or thoracotomy
Fleckenstein , J.; Kohls, Niko; Irnich , D. (2012)
14th World Congress of the International Association for the Study of Pain. Milano, Italien. August 27-31, 2012..
Peer Reviewed
Erkanntes und Erlebtes - Die Geschichte eines Buches des protestantischen Gelehrten Wilhelm Wundt aus dem Besitz des jüdischen Apothekers Leopold Scheyer
Andert, K.; Kohls, Niko (2012)
Bibliotheksdienst, 11, 908 – 912., 908-912.
Are spiritual and transpersonal aspects important for “Clinical Parapsychology”?
Kohls, Niko (2012)
In W. Kramer, E. Bauer & G. Hövelmann (Eds.), Perspectives of Clinical Parapsychology (pp. 135 - 148). Bunnik: Stichting Het Johan Borgman Fonds., 135-148.
Towards Enhancing Healing Processes by Developing and Facilitating Technological Aspects of Optimal Healing Environments - Setting the Stage
Kohls, Niko; M., Ives, , J.; Sakallaris, B.; Jonas, W. B. (2012)
In M. Bachmann, J. Ives, N. Kohls & H. Plischke (Eds.), Toward Optimal Healing Environments. Symposium on Assistive Systems for Social, Personal, and Health Interaction (Vol. 1, pp. 18-23). Virginia: Samuel Institute Conference Proceedings. Vol.1, 18-23.
A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis
Mazargui , Honoree; Lévêque , Christian ; Bartnik , Dirk ; Fantini , Jacques ; Melone, Mariarosa A.B. ; Funke, Susanne A.; Willbold, Dieter; Perrone , Lorena (2012)
Mazargui , Honoree; Lévêque , Christian ; Bartnik , Dirk ; Fantini , Jacques ...
Aing Cell
11, 3.
DOI: 10.1111/j.1474-9726.2012.00814.x
Open Access Peer Reviewed
Identification and Characterization of an Aβ Oligomer Precipitating Peptide That May Be Useful to Explore Gene Therapeutic Approaches to Alzheimer Disease
Funke, Susanne A.; Liu, Hongmei ; Sehl, Torsten ; Bartnik , Dirk ; Brener, Oleksandr; Nagel-Steger, Luitgard; Wiesehan , Katja ; Willbold, Dieter (2012)
Funke, Susanne A.; Liu, Hongmei ; Sehl, Torsten ; Bartnik , Dirk ; Brener, Oleksandr...
Rejuvenation Research Vol. 15, No. 2
15, 2 | 144-147..
DOI: 10.1089/rej.2011.1262
Open Access Peer Reviewed
Detection of α-synuclein aggregates by fluorescence microscopy
Hübinger, S. ; Bannach , Oliver; Funke, Susanne A.; Funke, Susanne A.; Willbold, Dieter; Birkmann, Eva (2012)
Hübinger, S. ; Bannach , Oliver; Funke, Susanne A.; Funke, Susanne A....
Rejuvenation Res. 15, 15, 2 | 213- 216..
DOI: 10.1089/rej.2011.1288
Open Access Peer Reviewed
Burnout – Risikofaktor und Prävention – Die „Ausgebrannten“ werden immer jünger
Kohls, Niko; Rieß, J.; Sigl, C.; Offenbaecher, M. (2012)
Die BKK 04/2012, 184 – 187..
How long is now for mindfulness meditators?
Sauer, S.; Lemke, J.; Wittmann, M.; Kohls, Niko; Mochty, , U.; Walach, H. (2012)
Personality and Individual Differences, 52(6), 750-754..
Peer Reviewed
Psychische Belastungen von Medizinstudierenden an den Universitäten München und Witten/Herdecke – ein Vergleich
Kohls, Niko; Büssing, Arndt; Sauer, S.; Rieß, A.; Ulrich, C.; Vetter, A.; Jurkat, H. (2012)
Kohls, Niko; Büssing, Arndt; Sauer, S.; Rieß, A.; Ulrich, C.; Vetter, A....
Zeitschrift für Psychosomatische Medizin und Psychotherapie, 58 (4), 409-416. , 409-416.
Peer Reviewed
Specific Objectivity of Mindfulness—A Rasch Analysis of the Freiburg Mindfulness Inventory
Kohls, Niko; Sauer, S. (2012)
Mindfulness, 4(1), 45-54., 45-54.
Peer Reviewed
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