QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015)
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A....
Scientific Reports 2015 / 5, 13222.
DOI: 10.1038/srep13222
Open Access Peer Reviewed
Strong evidence exists for a central role of amyloid ß-protein (Aß)
oligomers in the pathogenesis of Alzheimer`s disease. We have developed a
fast, reliable and robust in vitro assay, termed QIAD, to quantify the
effect of any compound on the Aß aggregate size distribution. Applying
QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the
benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and
its tandem version D3D3 on Aß aggregation. The predictive power of the
assay for in vivo efficacy is demonstrated by comparing the oligomer
elimination efficiency of D3 and D3D3 with their treatment effects in
animal models of Alzheimer´s disease.
Fördernde Faktoren für eine Gesundheitsförderung in der Allgemeinarztpraxis – ein fokussierter Review
Offenbächer, M.; Poggenburg, S.; Schelling, J.; Hirsch, J. K.; Sirios , F. ; Toussaint, L.; Esch, Tobias; Nöfer, Eberhard; Kohls, Niko (2015)
Offenbächer, M.; Poggenburg, S.; Schelling, J.; Hirsch, J. K.; Sirios , F. ...
Posterbeitrag bei dem Kongress der Deutschen Gesellschaft für Allgemein- und Familienmedizin, Bozen, 17. – 19. September 2015..
Peer Reviewed
Die Umsetzung der Solvency II-Gruppenaufsicht im deutschen Versicherungsaufsichtsgesetz (VAG): Inwieweit gilt deutsches Recht für die Beaufsichtigung internationaler Versicherungsgruppen?
Kraft, Mirko (2015)
Zeitschrift für die gesamte Versicherungswissenschaft (ZVersWiss) 104 (4), 389-409.
DOI: 10.1007/s12297-015-0311-0
Open Access Peer Reviewed
SWEBOS - The Software Engineering Body of Skills
Sedelmaier, Yvonne; Landes, Dieter (2015)
International Journal of Engineering Pedagogy (iJEP) 5, 1 | 12–19..
DOI: 10.3991/ijep.v5i1.4047
Open Access Peer Reviewed
Social Work as a Human Rights Profession
Lohrenscheit , Claudia (2015)
Vortrag im Rahmen des Seminars “Social Work Sciences” an der University of the Free State, Bloemfontein, South Africa, 1.9.2015.
New racist and right wing movements in Germany: How to struggle with human rights against mainstream racism
Lohrenscheit , Claudia (2015)
Vortrag zur Canrad Conference on Non-Racialism in South Africa, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa, 29.8.2015.
Dimensionierungsfaktoren für Luftleitungen. Ökonomische und energetische Einflüsse sowie Möglichkeiten zur SFP-orientierten Auslegung.
Kriegel, Martin; Schaub, Michael (2015)
HLH 66 (8), 33-36.
DYNAMIKOmorph: Wenn Dinge von der Zeit erzählen. Visuelle Grundmuster prozessualen Wahrnehmens und ihr Potential für Kunst, Architektur und Gestaltung
Heinrich, Michael (2015)
Zwischen den Welten: Strömungen, Cuvillier-Verlag.
Mindful in a random forest: Assessing the validity of mindfulness items using random forests methods
Sauer, S.; Lemke, J.; Zinn, W.; Büttner, R.; Kohls, Niko (2015)
Personality and Individual Differences, 81(0), 117-123. , 117-123.
Peer Reviewed
Menschenrechte, Migration und Flucht
Lohrenscheit , Claudia (2015)
Einzelvortrag, JUZ Domino, Coburg.
Szenographie. Der lebendige Raum
Heinrich, Michael (2015)
BDIA Impulse, AIT, 06/2015.
Structure characterization of unexpected covalent O-sulfonation and ion-pairing on an extremely hydrophilic peptide with CE-MS and FT-ICR-MS
Pattky, Martin ; Nicolardi , Simone ; Santiago-Schübel , Beatrix ; Sydes , Daniel ; van der Burgt , Yuri E. M.; Klein, Antonia Nicole ; Jiang , Nan; Mohrlüder, Jeannine ; Hänel , Karen ; Kutzsche, Janine; Funke, Susanne A.; Willbold, Dieter; Willbold , S.; Huhn, C. (2015)
Pattky, Martin ; Nicolardi , Simone ; Santiago-Schübel , Beatrix ; Sydes , Daniel ...
Analytical and Bioanalytical Chemistry volume 407 407 (22), 6637-55.
DOI: 10.1007/s00216-015-8826-8
Open Access Peer Reviewed
Zukunftskonferenz
Lohrenscheit , Claudia (2015)
Fachmoderation der Zukunftskonferenz des Vereins Hilfe für das behinderte in, Coburg e.V..
Menschenrechte und Migration
Lohrenscheit , Claudia (2015)
Input und Diskussionsteilnehmerin der Podiumsdiskussion im Rahmen der Internationalen Woche Coburg.
E-learning innovations for the education of general practitioners at the Bavarian Virtual University (BVU)–a model for other countries
Vogel , B.; Kormann, C.; Mehring , M. ; Schneider, A.; Offenbächer, M.; Kohls, Niko; Schelling, J. (2015)
Vogel , B.; Kormann, C.; Mehring , M. ; Schneider, A.; Offenbächer, M.; Kohls, Niko...
Bio-Algorithms and Med-Systems, 11(2), 107-111., 107-111.
Peer Reviewed
Peacebuilding - Gender - Social Work
Lohrenscheit , Claudia (2015)
Moderation der internationalen Konferenz an der Hochschule Coburg.
Chaperone network composition in Solanum lycopersicum explored by transcriptome profiling and microarray meta-analysis
Fragkostefanakis, Sotirios; Simm, Stefan; Paul, Puneet; Bublak, Daniela; Scharf, Klaus-Dieter; Schleiff, Enrico (2015)
Fragkostefanakis, Sotirios; Simm, Stefan; Paul, Puneet; Bublak, Daniela...
Plant, Cell & Environment 38 (4), 693–709.
DOI: 10.1111/pce.12426
Open Access Peer Reviewed
Heat shock proteins (Hsps) are molecular chaperones primarily involved in maintenance of protein homeostasis. Their function has been best characterized in heat stress (HS) response during which Hsps are transcriptionally controlled by HS transcription factors (Hsfs). The role of Hsfs and Hsps in HS response in tomato was initially examined by transcriptome analysis using the massive analysis of cDNA ends (MACE) method. Approximately 9.6% of all genes expressed in leaves are enhanced in response to HS, including a subset of Hsfs and Hsps. The underlying Hsp-Hsf networks with potential functions in stress responses or developmental processes were further explored by meta-analysis of existing microarray datasets. We identified clusters with differential transcript profiles with respect to abiotic stresses, plant organs and developmental stages. The composition of two clusters points towards two major chaperone networks. One cluster consisted of constitutively expressed plastidial chaperones and other genes involved in chloroplast protein homeostasis. The second cluster represents genes strongly induced by heat, drought and salinity stress, including HsfA2 and many stress-inducible chaperones, but also potential targets of HsfA2 not related to protein homeostasis. This observation attributes a central regulatory role to HsfA2 in controlling different aspects of abiotic stress response and tolerance in tomato.
No effect of the cyclooxygenase-2 inhibitor etoricoxib on pre-emptive and post-operative analgesia in visceral surgery: results of a randomized controlled trial
Fleckenstein , J.; Kohls, Niko; Evtouchenko, E.; Lehmeyer, L.; Kramer, S.; Lang , P. M. ; Siebeck , M. ; Mussak , T. ; Hatz , R. ; Heindl , B. ; Conzen, P.; Czerner , S. ; Zwißler, B. ; Irnich , D. ; Rehm, M. (2015)
Fleckenstein , J.; Kohls, Niko; Evtouchenko, E.; Lehmeyer, L.; Kramer, S....
European Journal of Pain 2015 / 20 (2).
DOI: 10.1002/ejp.699
Open Access Peer Reviewed
Barriers for Health Promotion in General Practice –a Systematic Review. 55
Offenbaecher, M.; Ritter, S.; Schilling,, D.; Kohls, Niko; Esch, Tobias; Nöfer, Eberhard (2015)
Offenbaecher, M.; Ritter, S.; Schilling,, D.; Kohls, Niko; Esch, Tobias...
Scientific Meeting of the German Society for Occupational Medicine, Munich, 18. – 20.3.2015.
Peer Reviewed
Menschenrechte und Flucht
Lohrenscheit , Claudia (2015)
Vortrag im Rahmen eines Workshops an der Berufsschule Kanalstrasse, Coburg.
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monika.schnabel[at]hs-coburg.de