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A highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease

Birkmann, Eva; Henke, Franziska; Funke, Susanne A.; Bannach , Oliver; Riesner, Detlev...

Rejuvenation Research 11, 2, S. 359-363..
DOI: 10.1089/rej.2008.0697


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Fabrication of nano-electrodes by means of controlled electrochemical deposition of gold

Wolf, Conrad R.; Gerster, Daniel; Thonke, Klaus; Sauer, Rolf (2008)

DPG Frühjahrstagung 2008 (Berlin).


 

In the emerging fields of nano- and molecular electronics a strong need for nano-electrodes arises from the wish to contact objects such as quantum dots or single molecules. In this contribution we show the use of a controlled electrochemical deposition scheme to fabricate stable electrodes with spacings below 10 nm. In our experiments we start with a pair of gold electrodes separated by a 200 nm gap prepared by electron beam lithography. These electrodes are immersed into a solution of KI and I2 in ethanol which has been saturated by dissolving gold in it [1]. Both nano-electrodes are connected to the same DC potential, while an AC voltage between them is used to in-situ monitor the conductance with a lock-in amplifier. For the deposition a DC voltage is applied to the counter electrode until the recorded conductance reaches the desired value. It is also possible to reversibly close and open the electrode gap by applying positive and negative voltages, respectively, to the counter electrode. With this technique gaps of around 1 nm can be realized, as conductance measurements after rinsing and drying as well as SEM micrographs show. When the electrodes are grown together slowly, we observe a step-wise increase in the conductance which corresponds to integer multiples of the conductance
quantum 2e2/h.


Effectiveness of Distant Healing for Patients with Chronic Fatigue Syndrome: A Randomised Controlled Partially Blinded Trial

Walach, H.; Bösch, H.; Lewith, G.; Naumann, M.; Schwarzer, B.; Falk, S.; Kohls, Niko...

Psychotherapy and Psychosomatics, 77(3), 158-166., S. 158-166.



Validating four standard scales in spiritually practicing and non-practicing samples using propensity score matching

Kohls, Niko; Walach, H. (2008)

European Journal of Psychological Assessment, 24(3), 165-173., S. 165-173.


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Evolution of Enantioselective Bacillus subtilis Lipase

Eggert, Thorsten ; Funke, Susanne A.; Andexer , JN; Reetz , Manfred T. ...

book chapter in: Protein Engineering Handbook, 1. Auflage 2008.



Measuring the Unmeasurable by Ticking Boxes and Actually Opening Pandoras Box?

Kohls, Niko; Hack, A.; Walach, H. (2008)

Mixed Methods Research as a useful tool for thinking out of the box while investigating Exceptional Human Experiences. The Archive for the Psychology of Religion, 30, 155-187., S. 155-187.



Single particle detection of Aβ aggregates associated with Alzheimer’s disease

Funke, Susanne A.; Birkmann, Eva; Henke, Franziska; Görtz, Philipp...

Biochemical and Biophysical Research Communications 364, 4, S. 902-907.
DOI: 10.1016/j.bbrc.2007.10.085


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Beurteilung und Umsetzung des KICK in der Praxis bayerischer Jugendämter. Eine Erkundungsstudie.

Buchholz-Schuster, Eckardt (2007)

Zeitschrift für Kindschaftsrecht und Jugendhilfe 2007 (12), S. 467 ff..



Fabrication of nano-electrodes by means of controlled electrochemical deposition of gold

Wolf, Conrad R.; Gerster, Daniel; Thonke, Klaus; Sauer, Rolf (2007)

Workshop Metal Deposition for Emerging Nanoelectronic Applications (Schloß Reisensburg, Günzburg).


 

In the emerging fields of nano- and molecular electronics a strong need for nano-electrodes arises from the
wish to be able to contact single nano-objects such as quantum dots (QDs) or molecules. There are different methods
known from literature how to fabricate such electrodes, for example electromigration, mechanically controllable break
junctions, or scanning probe techniques, all of which have their specific advantages and drawbacks. In this talk we will
use a scheme of controlled electrochemical deposition which features the following benefits: the electrodes are stable,
no islands are unintentionally created during the fabrication process, and it is relatively straight forward to implement a
third electrode acting as gate.
In our experiments we start with a pair of gold electrodes separated by a 200 nm gap (Fig. 2 (a)) prepared by
electron beam lithography (EBL). These electrodes are immersed into a solution of KI and I2 in ethanol which has been
saturated by dissolving gold in it [1]. Gold covered glass sheets are used as counter and reference electrodes. For the
deposition both nano-electrodes are connected to the same DC potential, while a voltage is either applied directly to the
counter electrode or a potentiostat setup is used. Additionally an AC voltage is applied between the two nano-electrodes
which allows us to in-situ monitor the conductance with a lock-in amplifier (see Fig. 1).
When the sample is immersed into the solution, the conductance rises due to ionic currents. For the deposition
a voltage of typically 60 mV is applied to the counter electrode with respect to the working electrodes. The conductance
is recorded until it reaches a threshold value at which the deposition is stopped. After deposition the gap between the
two electrodes is clearly below 10 nm, as conductance measurements after rinsing and drying as well as the SEM
micrograph in Fig. 2 (b) show.
It is planed to place semiconductor QDs or single molecules between the electrodes to measure their transport
characteristics. Furthermore samples with additional back gate electrode are in preparation which will provide an even
wider access to the electrical properties of nano-objects.


Counting of single prion particles bound to a capture-antibody surface (surface-FIDA)

Birkmann, Eva; Henke, Franziska; Weinmann, Nicole ; Dumpitak , Christian ...

Veterinary Microbiology 123, 4, S. 294-304.
DOI: 10.1016/j.vetmic.2007.04.001


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Research Digest

Kohls, Niko (2007)

Commentary on Cotton, Zebracki, Rosenthal, Tsevat & Drotar (2006) and Wachholtz & Pargament (2006). Spirituality & Health International, 8 (2), p 101–105., S. 101-105.



Evidence Based Spirituality

Kohls, Niko (2007)

(2007), Network Review, 94, p. 26 - 27, S. 26-27.



Purification of recombinantly expressed and cytotoxic human amyloid-beta peptide 1-42

Wiesehan , Katja ; Funke, Susanne A.; Miriam , Fries ; Willbold, Dieter (2007)

Journal of Chromatography B 856, 1-2, S. 229-233.
DOI: 10.1016/j.jchromb.2007.06.003


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Fabrication of silicon quantum dot single-electron transistors by a combination of self-assembly and self-alignment techniques

Wolf, Conrad R. (2007)

E-MRS Spring Meeting 2007 (Strasbourg, France).


 

We present a technique to fabricate single-electron transistors (SETs) with silicon quantum dots (QDs) as conducting islands making use of a combination of self-assembly and self-alignment effects. Starting from an ultra-thin silicon-on-insulator (SOI) substrate we employ aminosilane as an adhesion agent to self-assemble gold colloidal particles in a sub-monolayer. These particles are then used as an etch mask for a CF4 reactive ion etch (RIE) process in which the silicon is removed everywhere except below the gold colloids, yielding silicon QDs on a SiO2 layer. A metal wire together with side gate electrodes is patterned by electron beam lithography (EBL) onto the QD-covered sample, and a nanometer-sized gap is created in these wires by a controlled electromigration process. Self-alignment of the evolving nano-electrodes with respect to the QDs is achieved, because the metal layer is locally dilated by the QDs resulting in a locally higher current density. Therefore the metal wires will preferentially break at the positions of the QDs. To obtain tunneling contacts the native oxide layer covering the silicon QDs is used as a tunneling barrier. Its thickness can be adjusted in a controlled manner by self-limiting thermal oxidation to obtain an accurate tunneling resistance. The devices are electrically characterized at liquid helium temperature and show clear Coulomb blockade behavior, Coulomb staircase features and the so-called Coulomb diamonds which are typical for SETs.


SOI-based single-electron transistors fabricated by a combination of self-assembly and self-alignment techniques

Wolf, Conrad R.; Thonke, Klaus; Sauer, Rolf (2007)

DPG Frühjahrstagung 2007 (Regensburg).


 

We present a technique to fabricate single-electron transistors (SETs) with silicon quantum dots (QDs) as conducting islands making use of a combination of self-assembly and self-alignment effects. Starting from an ultra-thin silicon-on-insulator (SOI) substrate we
employ self-assembled gold colloidal particles as an etch mask. Quantum dots are then fabricated by applying a CF4 reactive ion etch
(RIE) process to remove the silicon layer everywhere except below the gold colloids. A 100-200 nm wide metal wire together with side
gate electrodes is patterned by electron beam lithography (EBL) onto the QD-covered sample and a nanometer-sized gap is created in these wires by a controlled electromigration process. The metal wires will preferentially break at the positions of the QDs, because the metal layer is dilated there resulting in a locally higher current density. This leads to a self-alignment effect of the evolving nano-electrodes with respect to the QDs. The native oxide layer covering the silicon QDs is used as a tunneling barrier. Its thickness can optionally be adjusted in a controlled manner by self-limiting thermal oxidation to obtain an accurate tunneling resistance. The devices are electrically characterized at liquid helium temperature and show clear Coulomb blockade behavior, Coulomb staircase features as well as the so-called Coulomb diamonds, typical for SETs.


Development of an ultra-sensitive assay for early diagnosis of Alzheimer's disease

Funke, Susanne A.; Birkmann, Eva; Henke, Franziska; Riesner, Detlev (2007)

BMC Neuroscience 8, P24.
DOI: 10.1186/1471-2202-8-S1-P24


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Fabrication and characterization of self-assembled and self-aligned SOI-based single-electron transistors

Wolf, Conrad R.; Thonke, Klaus; Sauer, Rolf (2007)

Trends in Nanoscience 2007 (Kloster Irsee).


 

We present a novel technique to fabricate single-electron transistors (SETs) with silicon quantum dots (QDs) as
conducting islands making use of a combination of self-assembly and self-alignment effects (for an overview of the
fabrication process, see Fig. 1). Starting from an ultra-thin silicon-on-insulator (SOI) substrate we employ aminosilane
molecules as an adhesion agent to self-assemble gold colloidal particles in a sub-monolayer [1]. These particles are then
used as an etch mask for a CF4 reactive ion etch (RIE) process in which the silicon layer is removed everywhere except
below the gold colloids, yielding silicon QDs on a SiO2 insulating layer. A metal wire together with symmetric side gate
electrodes is patterned by electron beam lithography (EBL) onto the QD-covered sample, and a nanometer-sized gap is
created in these wires by a controlled electromigration process [2]. Self-alignment of the evolving nano-electrodes with
respect to the QDs is achieved, because the metal layer is locally dilated by the QDs resulting in a locally higher current
density. Therefore the metal wires will preferentially break at the positions of the QDs. To obtain tunneling contacts the
native oxide layer covering the silicon QDs is used as a tunneling barrier. Its thickness can be adjusted in a controlled
manner by self-limiting thermal oxidation [3] to obtain an accurate tunneling resistance.
The devices are electrically characterized at liquid helium temperature by applying a source-drain voltage and
measuring the current. The I(V)-curves (Fig. 2) show clear Coulomb blockade behavior and Coulomb staircase features.
When the source-drain voltage is kept at a constant value and the gate voltage is varied, conductance oscillations
become visible. By collecting ISD(VSD)-traces for different gate voltages and calculating their numerical derivatives a so-
called stability diagram is obtained, exhibiting Coulomb diamonds which are typical for SETs.


Spiritualität, Krankheit und Heilung - Bedeutung und Ausdrucksformen der Spiritualität in der Medizin - Perspektiven, Schriften zur Pluralität in der Medizin und Komplementärmedizin

Sommer, A.; Kohls, Niko (2007)

In A. Büssing, T. Ostermann, M. Glöckler & P. Matthiessen (Eds.),.Frankfurt: Verlag für akademische Schriften, S. 194-218.



Kostenrechnung

Sigloch, Jochen; Chen, Hongyan; Demmler, Uwe (2007)

2007.



Psychological Distress, Experiences of Ego Loss and Spirituality: Exploring the Effects of Spiritual Practice

Kohls, Niko; Walach, H. (2007)

Social Behaviour and Personality, 35 (10), 1301-1316. , S. 1301-1316.


Peer Reviewed

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