Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio; Bosch, Thomas; Wenck, Horst; Winnefeld, Marc; Grönniger, Elke; Simm, Stefan; Siracusa, Annette (2022)
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio...
The Journal of Investigative Dermatology 142 (12), 3136–3145.e11.
DOI: 10.1016/j.jid.2022.06.023
Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and adequately respond to external stressors. Macrophages are important gatekeepers of tissue homeostasis, and it has been reported that their number and phenotype change during aging in a site-specific manner. How aging affects human skin macrophages and what implications this has for the aging process in the tissue are still not fully understood. Using single-cell RNA-sequencing analysis, we show that there is at least a 50% increase of macrophages in human aged skin, which appear to have developed from monocytes and exhibit more proinflammatory M1-like characteristics. In contrast, the cell-intrinsic ability of aged monocytes to differentiate into M1 macrophages was reduced. Using coculture experiments with aged dermal fibroblasts, we show that it is the aged microenvironment that drives a more proinflammatory phenotype of macrophages in the skin. This proinflammatory M1-like phenotype in turn negatively influenced the expression of extracellular matrix proteins by fibroblasts, emphasizing the impact of the aged macrophages on the skin phenotype.
Meißner, Karin (2022)
Eingeladener Vortrag, Gründungsveranstaltung für das REGIOMED Zentrum für Wirbelsäulenmedizin, Regiomed Klinikum Lichtenfels .
Kalkhof, Stefan (2022)
e:Med Meeting 2022 on Systems Medicine November 28-30, 2022 Heidelberg, DKFZ Communication Center.
Guliyev , V.; Tanunchai, Benjawan; Noll, Matthias; Buscot, F.; Purahong, W.; Blagodatskaya , E. (2022)
Guliyev , V.; Tanunchai, Benjawan; Noll, Matthias; Buscot, F.; Purahong, W....
MDPI Polymers 14, 2801.
DOI: 10.3390/polym14142801
Meißner, Karin (2022)
Vortrag auf der internationalen Tagung "The structure of creditions - methods, methodology, and assessment", Graz, Österreich.
Leidner, Jochen L. (2022)
Invited Talk, Joint Webinar of the CFA organization (French Chapter) and the London Stock Exchange Group (LSEG), London/Paris/online, November 18, 2022.
Kipping, Lydia; Maurer, Florian; Gossner, Martin M.; Muszynski, Sarah; Kahl, Tiemo; Kellner, H.; Weisser, Wolfgang W.; Jehmlich, N.; Noll, Matthias (2022)
Kipping, Lydia; Maurer, Florian; Gossner, Martin M.; Muszynski, Sarah; Kahl, Tiemo...
Frontiers in Forest & Global Change 5, 1020737.
DOI: 10.3389/ffgc.2022.1020737
Gross, Hellen (2022)
Vortrag auf dem Kulturworkshop „Kultur in Coburg - Zukunft gemeinsam gestalten“ auf Einladung der Kulturbeauftragten des Stadtrates zu Coburg Antoinetta Bafas.
Meißner, Karin (2022)
Oral presentation, 2022 Xing-lin International Week of Chengdu University of Traditional Chinese Medicine (CDUTCM).
Kenzel, Julia; Brüggemann, Dagmar Adeline; Funke, Susanne A. (2022)
Applied Microbiology 2022 (4), 2 | 921-933.
DOI: 10.3390/applmicrobiol2040070
Meißner, Karin (2022)
Vortrag im Rahmen der Vorlesungsreihe "Hot Topics in Psychology", TUM Fakultät für Sport- und Gesundheitswissenschaften.
Schaub, Michael (2022)
Korallenriff-Magazin 11, 28-33.
DOI: 10.13140/RG.2.2.21894.65605
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie; Olliges, Elisabeth; Kraft, Jana; Popovici, R. M.; Meißner, Karin (2022)
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie...
Frauenarzt - Offizielles Organ des Berufsverbands der Frauenärzte e.V. (BVF) sowie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. (DGGG) 63 (11), 722 – 726.
Lohrenscheit , Claudia (2022)
Moderation 2022.
Kohls, Niko (2022)
Online-Keynote Veranstaltungsreihe „7 Lektionen zum Glück in der Medizin - Resilienz, Sinnhaftigkeit und Gesundheit für Mitarbeiter*innen im Gesundheitswesen“ des Philosophicum Herbipolense der Universität Würzburg, 27.10.2022. .
Gross, Hellen; Rottler, M. (2022)
Handbuch Kulturpolitik, Springer VS Wiesbaden.
DOI: 10.1007/978-3-658-34381-1
Stöver, Heino; Hößelbarth, Susann (2022)
Stöver, H. & Hößelbarth, S. (2022). Drogenkonsum/-abhängigkeit im Alter – Stigmatisierung und Ausgrenzung. In: P.C. Langer, J. Drewes & D. Schaarenberg (Hrsg.) Altern mit Stigma. Gesellschaftliche und psychosoziale Perspektiven des Älterwerdens in stigmatisierten Lebenskontexten (S. 105-142). Wiesbaden: Springer VS-Verlag, 105-142.
DOI: 10.1007/978-3-658-37216-3
Kohls, Niko (2022)
The Sacralization of Knowledge – A Core Dynamics of the Western Paradigm of Progress and its Architectural Expression within the College Topos, Jesus College, University of Cambridge, 16. Oktober 2022..
Meißner, Karin (2022)
Oral presentation, 35th ICMART World Medical Acupuncture Congress, Bologna, Italy.
Kuhn, Maria; Kohls, Niko; Hinterberger, T. (2022)
Geburtshilfe Frauenheilkd, 82(10), 194.
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