Peters, Christoph; Kuth, Bastian; Meyer, Quirin (2022)
ACM SIGGRAPH Symposium on
Interactive 3D Graphics and Games
Online: May 3-5 2022.
DOI: 10.1145/3522607
Holtorf, Christian; Leidner, Jochen L. (2022)
Rahmen der Literaturtage „Coburg liest“ 2022. 2022.
Heinrich, Michael; Christian, Illies (2022)
Wissen über Gesundheit. uni.vers Forschung: Das Magazin der Otto-Friedrich-Universität Bamberg 2022.
Heinrich, Michael (2022)
Architecture by Fraunhofer, Fraunhofer Netzwerk Wissenschaft, Kunst und Design.
Phillips, Mark (2022)
Prüfung hoch drei. Didaktik. Technik. Vernetzung 2022.
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine; Geyer, Joachim; Simm, Stefan; Tzvetkov, Mladen (2022)
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine...
International Journal of Molecular Sciences 23 (9), 5100.
DOI: 10.3390/ijms23095100
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing in six additional dog breeds. Next, dog OCT1 and OCT2 were stably overexpressed in HEK293 cells and the transport kinetics of five drugs were analyzed. We observed strong differences in the transport kinetics between dog and human orthologs. Dog OCT1 transported fenoterol with 12.9-fold higher capacity but 14.3-fold lower affinity (higher KM) than human OCT1. Human OCT1 transported ipratropium with 5.2-fold higher capacity but 8.4-fold lower affinity than dog OCT1. Compared to human OCT2, dog OCT2 showed 10-fold lower transport of fenoterol and butylscopolamine. In conclusion, the functional characterization of dog OCT1 and OCT2 reported here may have implications when using dogs as pre-clinical models as well as for drug therapy in dogs.
Heinrich, Michael (2022)
VHS Coburg.
Kipping, Lydia; Gossner, Martin M.; Koschorreck, Matthias; Muszynski, Sarah; Maurer, Florian; Weisser, Wolfgang W.; Noll, Matthias (2022)
Kipping, Lydia; Gossner, Martin M.; Koschorreck, Matthias; Muszynski, Sarah...
Global Biogeochemical Cycles 2022 (36), 5.
DOI: 10.1029/2021GB007143
Meißner, Karin; Olliges, Elisabeth; Weimer, K.; Beissner, F. (2022)
Complementary Medicine Research 29 (2), 23-29.
DOI: 10.1159/000524073
Tanunchai, Benjawan; Schroeter , Simon Andreas; Ji, Li; Wahdan, S. F. M.; Hossen, Shakhawat; Lehnert , A.-S.; Grünberg, H.; Gleixner, Gerd; Buscot, F.; Schulze, Ernst-Detlef ; Noll, Matthias; Purahong, W. (2022)
Tanunchai, Benjawan; Schroeter , Simon Andreas; Ji, Li; Wahdan, S. F. M....
Frontiers in Microbiology 13, 90753.
DOI: 10.3389/fmicb.2022.907531
Scheid, Sarah-Maria ; Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Buscot , F.; Noll, Matthias; Purahong , W. (2022)
Scheid, Sarah-Maria ; Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Buscot , F....
Brief Communication.
DOI: 10.1007/s10924-022-02435-z
Kettner, Alexander; Noll, Matthias; Griehl, C. (2022)
MDPI Biomolecules 2022 (504), 12.
DOI: 10.3390/biom12040504
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva; Jarczok, Marc N.; Weimer, K. (2022)
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva...
Poster presentation A1634, 79th Annual Scientific Meeting of the American Psychosomatic Society (APS), March 23-26, 2022, Long Beach, California, US 84 (5), A1-A153.
DOI: 10.1097/PSY.0000000000001095
Arbeiter, Georg (2022)
Podcast Radio Eins.
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela; Grundhoff, Adam; Wegwitz, Florian ; Kalkhof, Stefan; Hildebrand, Janosch (2022)
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela...
Cells 11 (6), 959.
DOI: 10.3390/cells11060959
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M.; Jonas, Malter; Buscot, F.; Noll, Matthias (2022)
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M....
Proceedings of the Royal Society Biological Sciences 2022, 20220130.
DOI: 10.1098/rspb.2022.0130
Heinrich, Michael (2022)
Bayern 2, Bayerischer Rundfunk, 2022.
Kohls, Niko (2022)
Unternehmerforum Ruhr, Keynote, Online-Event.
Wilde, Mathias; Rebhan , Jakob (2022)
Standort - Zeitschrift für Angewandte Geographie 46 (1), 2-8.
DOI: 10.1007/s00548-021-00746-2
Kohls, Niko (2022)
Report Psychologie 47 (3), 6-10.
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg