Podcast "Fränkischer Talk" - Chris Zagel, wie lebt es sich mit Mikrochips unter der Haut?
Zagel, Christian (2024)
Fränklischer Tag - Podcast.
Towards Practical Meshlet Compression
Kuth, Bastian; Oberberger, Max; Kawala , Felix ; Reitter, Sander; Michel, Sebastian; Chajdas, Matthäus; Meyer, Quirin (2024)
Kuth, Bastian; Oberberger, Max; Kawala , Felix ; Reitter, Sander; Michel, Sebastian...
Buch (Sammelband) 2024.
DOI: 10.2312/vmv.20241204
Open Access Peer Reviewed
Entwicklungsstand Wärmepumpen-Technologie – Anwendungsmöglichkeiten im Denkmal
Schaub, Michael (2024)
Seminar Nachhaltige Wärmeversorgung im Denkmal - Exkursion Marktbreit.
Droplet Based Platform for the Detection of Environmental Pollutants with Fluorescent DNA Quantum Clusters
Kluitmann, Jonas; Drese, Klaus Stefan (2024)
Posterpräsentation auf der EuroMBR Microfluidics Catanzaro, September 2024 .
Jörg Zittlau: Täuschend heilsam
Meißner, Karin (2024)
Welt am Sonntag (Interview).
Einfluss des Ethanolgehalts in Ottokraftstoffen auf den Platinaustrag im Pkw-Abgaskondensat, untersucht mittels Voltammetrie im pg/L-Bereich
Flechsig, Gerd-Uwe; Kosturkov, Ivan; Staude, Kevin; Schröder, Olaf; Befolo, Olivier (2024)
Umwelt 2024 - Jahrestagung des SETAC GLB und der GDCh-Fachgruppe Umweltchemie und Ökotoxikologie, 8. - 11. September.
Vereinfachen wir die Richtlinien! Regelwerk der Gebäudetechnik.
Schaub, Michael; Floß, Alexander (2024)
Gebäude Energieberater 20 (07), 32-33.
Extrinsic rather than intrinsic factors determine microbial colonization of deadwood
Moll, Julia; Bässler, C.; Buscot, F.; Hoppe, B.; Jehmlich, N.; Kellner, H.; Muszynski, Sarah; Noll, Matthias (2024)
Moll, Julia; Bässler, C.; Buscot, F.; Hoppe, B.; Jehmlich, N.; Kellner, H....
Soil Biology and Biochemistry 2024 (199), 109608.
DOI: 10.1016/j.soilbio.2024.109608
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight
Klawitter, Marianne; Mattias, Francescapaola; Kliewe, Felix; Hammer, Elke; Völker, Uwe; Simm, Stefan; Siegerist, Florian; Daniel, Sophie; Schindler, Maximilian; Endlich, Nicole (2024)
Klawitter, Marianne; Mattias, Francescapaola; Kliewe, Felix; Hammer, Elke; Völker, Uwe...
American Journal of Physiology. Renal Physiology 327 (3), F463–F475.
DOI: 10.1152/ajprenal.00116.2024
Open Access Peer Reviewed
Identifying effective drugs for focal segmental glomerulosclerosis (FSGS) treatment holds significant importance. Our high-content drug screening on zebrafish larvae relies on nitroreductase/metronidazole (NTR/MTZ)-induced podocyte ablation to generate FSGS-like injury. A crucial factor for successful drug screenings is minimizing variability in injury induction. For this, we introduce nifurpirinol (NFP) as a more reliable prodrug for targeted podocyte depletion. NFP showed a 2.3-fold increase in efficiency at concentrations 1,600-fold lower compared with MTZ-mediated injury induction. Integration into the screening workflow validated its suitability for the high-content drug screening. The presence of crucial FSGS hallmarks, such as podocyte foot process effacement, proteinuria, and activation of parietal epithelial cells, was observed. After the isolation of the glomeruli from the larvae, we identified essential pathways by proteomic analysis. This study shows that NFP serves as a highly effective prodrug to induce the FSGS-like disease in zebrafish larvae and is well-suited for a high-content drug screening to identify new candidates for the treatment of FSGS.NEW & NOTEWORTHY This research investigated the use of nifurpirinol in nanomolar amounts as a prodrug to reliably induce focal segmental glomerulosclerosis (FSGS)-like damage in transgenic zebrafish larvae. Through proteomic analysis of isolated zebrafish glomeruli, we were further able to identify proteins that are significantly regulated after the manifestation of FSGS. These results are expected to expand our knowledge of the pathomechanism of FSGS.
Effects of meditation on health promoting protective factors of persons with cardiovascular disease—a quasi-experimental pilot study with pre-post comparison
Weiß, Katharina; Mahnkopf, Christian; Kohls, Niko (2024)
14 (4).
DOI: 10.21037/cdt-24-74
Open Access Peer Reviewed
Background: The aim of this pilot study is to determine, in the context of a controlled intervention study, whether the health-promoting personal protective factors of sense of coherence, resilience, and self-compassion are strengthened by the practice of Metta meditation in individuals with cardiovascular disease. The interactions between mind and body play a pivotal role in health and mortality. Lifestyle factors and especially stress also play a decisive role in the development and progression of cardiovascular diseases. With health-promoting personal protective factors, which can be actively formed over the entire lifespan, stressors can be managed more adequately.
Methods: Data collection will be conducted as part of a controlled nonrandomized longitudinal pilot intervention study that will enrol individuals with cardiovascular disease (n=29). After the first interview, a 12-week Metta meditation course will start for the intervention group (IG) (n=9), while the control group (CG) (n=20) will receive no intervention. The Minnesota Living with Heart Failure® Questionnaire (MLHFQ), the 13-item Sense of Coherence Scale (SOC-13), the Resilience Scale, the Self-Compassion Scale short form (SCS-sf) German version, the German version of the 10-item Perceived Stress Scale (PSS-10), and the Stress Coping subscale of the Stress and Coping Inventory (SCI) are used at both measurement time (MT) points. In addition, blood pressure parameters are collected. Furthermore, selected literature will be consulted to integrate the evaluated data into existing research findings.
Results: The health-promoting personal competencies of sense of coherence, resilience, and self-compassion were not strengthened by the practice of Metta meditation in individuals with cardiovascular disease. However, there was a significant reduction in perceived stress {F[1, 27] =4.351, P=0.047, f=0.402} and improved stress coping skills {F[1, 26] =6.790, P=0.02, f=0.511} in the IG. Furthermore, the frequency of rehospitalization {F[1, 27] =5.607, P=0.03, f=0.456} differed significantly in the pre-post comparison.
Conclusions: Due to the insufficient size of the sample, the results are only exploratory in nature and should therefore only be considered preliminary. Also, the correlations between the significant changes in the parameters and Metta meditation cannot be finally assessed. For this purpose, further studies with larger samples are needed.
Keywords: Loving-kindness meditation (LKM); sense of coherence; resilience; self-compassion; cardiovascular disease
Modalität und Shared Micro-Mobility: Die Nutzung von Verkehrsmitteln unter multioptionalen Bedingungen
Wilde, Mathias; Riedelbauch, Lukas (2024)
Internationales Verkehrswesen 76 (3), 48-50.
Profiles of well-being and their associations with self-forgiveness, forgiveness of others, and gratitude among patients with rheumatic and musculoskeletal diseases.
Charzyńska , Edyta; Offenbächer, M.; Halverson, k; Hirsch, J. K.; Kohls, Niko; Hanshans, Christian ; Sirois, F.; Toussaint, L. (2024)
Charzyńska , Edyta; Offenbächer, M.; Halverson, k; Hirsch, J. K.; Kohls, Niko...
British Journal of Health Psychology 2024, 1-23.
Peer Reviewed
Heilende Architektur - neue Konzepte für Krankenhäuser
Knümann, Verena; Koppen, Gemma; Vollmer, Tanja C. (2024)
SWR Fernsehen. Interview mit Gemma Koppen & Tanja C. Vollmer für das TV Program SWR-Kultur.
Real-Time Procedural Generation with GPU Work Graphs
Kuth, Bastian; Oberberger, Max; Faber, Carsten; Baumeister, Dominik; Chajdas, Matthäus; Meyer, Quirin (2024)
Kuth, Bastian; Oberberger, Max; Faber, Carsten; Baumeister, Dominik; Chajdas, Matthäus...
Zeitschrift 7 (3), 47.
DOI: 10.1145/3675376
Peer Reviewed
Ein guter Zeitpunkt, Richtlinien wieder stark zu vereinfachen. Die Zukunft von Heizlast, Kühllast, GEG-Nachweis und Co.
Schaub, Michael; Floß, Alexander (2024)
TGA+E Fachplaner 23 (08), 6-9.
Open Access
Vereinfachungen sind zwingend notwendig. Diskussionsbeitrag zur Zukunft von Heiz- und Kühllast, GEG-Nachweis und Co.
Schaub, Michael; Floß, Alexander (2024)
cci Zeitung 2024 (09), 10-11.
Open Access
A Novel Recursive Algorithm for the Implementation of Adaptive Robot Controllers
Kaya, Mertcan; Akbulut, Mehmet Ali ; Bayraktaroglu, Zeki Yagiz; Kühnlenz, Kolja Ernst (2024)
Kaya, Mertcan; Akbulut, Mehmet Ali ; Bayraktaroglu, Zeki Yagiz...
Journal of Intelligent & Robotic Systems 115, 110.
DOI: 10.1007/s10846-024-02135-x
Open Access Peer Reviewed
Therapeutic Architecture and Temporality: Evidence-Based Design for Long-Stay Facilities for Individuals with Severe Intellectual Disabilities and Challenging Behaviour.
Vollmer, Tanja C.; Koppen, Gemma; Iovita, Claudia; Schießl, Lara (2024)
Architecture 2024/4 (3), 541–570.
DOI: 10.3390/architecture4030029
Open Access Peer Reviewed
Concept and prototypic implementation of a tangible user interface for psychosocial interventions in the context of dementia
Leyendecker, Matthia; Zagel, Christian (2024)
AHFE International - The Human Side of Service Engineering 143, 167-177.
DOI: 10.54941/ahfe1005095
Open Access
Voltammetric Trace Analysis of Zn(II)-Pyrithione in Building Materials
Flechsig, Gerd-Uwe; Befolo, Olivier; Kosturkov, Ivan; Ramesh, Aparna (2024)
Poster auf der 19th International Conference on Electroanalysis ESEAC 2024, 23rd - 26th July, in Ulm.
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