Amidyl Radical Directed Remote Allylation of Unactivated sp3 C-H Bonds by Organic Photoredox Catalysis

Abstract

The development of visible-light-mediated allylation of unactivated sp3 C-H bonds is reported. The remote allylation was directed by the amidyl radical, which was generated by photocatalytic fragmentation of a pre-functionalized amide precursor. Both aromatic and aliphatic amide derivatives could successfully deliver the remote C-H allylation products in good yields. A variety of electron deficient allyl sulfone systems could be used as d-carbon radical acceptor. more

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Titel	Amidyl Radical Directed Remote Allylation of Unactivated sp3 C-H Bonds by Organic Photoredox Catalysis
Medien	Angewandte Chemie (International ed. in English)
Heft	6
Band	2019 58
Verfasser	K. Wu, L. Wang, S. Colón-Rodríguez, Prof. Dr. Gerd-Uwe Flechsig, T. Wang
Seiten	1774–1778
Veröffentlichungsdatum	2019-01-01
Zitation	Wu, K.; Wang, L.; Colón-Rodríguez, S.; Flechsig, Gerd-Uwe; Wang, T. (2019): Amidyl Radical Directed Remote Allylation of Unactivated sp3 C-H Bonds by Organic Photoredox Catalysis. Angewandte Chemie (International ed. in English) 2019 58 (6), 1774–1778. DOI: 10.1002/anie.201811004