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Selection and characterization of tau protein binding peptides as basis for future therapies for Alzheimer`s

Dammers, C.; Yolcu , D.; Kukuk, Laura; Willbold, Dieter; Pickhardt, Marcus ...

AD/PD 2019.
DOI: 10.1371/journal.pone.0167432


Peer Reviewed
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Methods for the Specific Detection and Quantitation of Amyloid-β Oligomers in Cerebrospinal Fluid

Schuster, Judith ; Funke, Susanne A. (2016)

J Alzheimers Dis 53, S. 53-67.
DOI: 10.3233/JAD-151029


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Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

Klein, Antonia Nicole ; Ziehm , Tamar ; Tusche, Markus; Buitenhuis , Johan ...

Plos One .
DOI: 10.1371/journal.pone.0153035


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Quantitation of Amyloid-β oligomers in human body fluids for Alzheimer’s disease early diagnosis or therapy monitoring

Funke, Susanne A.; Willbold, Dieter (2016)

Alzheimer's diagnosis, S. 1-24.
DOI: 10.3233/JAD-151029


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Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

Rudolph, Stephan; Klein, Antonia Nicole ; Tusche, Markus; Schlosser, Christine ...

PLOS ONE 11, 2.
DOI: 10.1371/journal.pone.0147470


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QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A....

Scientific Reports 5, 13222.
DOI: 10.1038/srep13222


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Structure characterization of unexpected covalent O-sulfonation and ion-pairing on an extremely hydrophilic peptide with CE-MS and FT-ICR-MS

Pattky, Martin ; Nicolardi , Simone ; Santiago-Schübel , Beatrix ; Sydes , Daniel ...

Analytical and Bioanalytical Chemistry volume 407 407, 6637-55 (22).
DOI: 10.1007/s00216-015-8826-8


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Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-Vaccines

Mandler, Markus; Santic, Radmila ; Gruber , Petra; Cinar, Yeliz ; Pichler, Dagmar ...

PLOS ONE.
DOI: 10.1371/journal.pone.0115237


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QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers

Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A....

Scientific reports 2015 5, S. 13222.
DOI: 10.1038/srep13222


Peer Reviewed
 

Strong evidence exists for a central role of amyloid ß-protein (Aß) oligomers in the pathogenesis of Alzheimer`s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aß aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aß aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.

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Detection and Quantitation of Amyloid-β Aggregates in Body Fluids may be Suitable for Early Diagnosis of Alzheimer’s Disease

Funke, Susanne A.; Birkmann, Eva; Willbold, Dieter (2014)

Advances in Alzheimer's Research 2.
DOI: 10.2174/9781608058525114020013


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The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity

Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A....

AIDS Research and Therapy 11, 1.
DOI: 10.1186/1742-6405-11-1


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Amyloid aggregation inhibitory mechanism of arginine-rich D-peptides

Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr...

National Library of Medicine National Center for Biotechnology Information, 1448-57.
DOI: 10.2174/0929867321666131129122247


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Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Old AβPP/PS1 Double Transgenic Mice

van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ...

J Alzheimers Dis. 2013; 34(3): 609–620. , 34, S. 609-620.
DOI: 10.3233/JAD-121792


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Characterization of a single-chain variable fragment recognizing a linear epitope of Aß: A biotechnical tool for studies on Alzheimer's disease?

Dornieden, Silke; Müller-Schiffmann, A.; Sticht, H.; Cinar, Yeliz ; Wördehoff, M....

Lawrence, Kan. PLoS 2013 , 8, S. e59820.
DOI: 10.1371/journal.pone.0059820


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The amyloid-β oligomer count in cerebrospinal fluid is a biomarker for Alzheimer's disease

Wang-Dietrich , Lei ; Funke, Susanne A.; Kühlbach , Katja ; Wang , Kun...

National Library of Medicine National Center for Biotechnology Information, 34.
DOI: 10.3233/JAD-122047.


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Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy

Sun, Na; Hartmann, Rudolf ; Lecher, Justin ; Stoldt , Matthias ; Funke, Susanne A....

J Pept Sci 2012 Nov;18(11):691-5 2012, 18.
DOI: 10.1002/psc.2456


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Mirror image phage display--generating stable therapeutically and diagnostically active peptides with biotechnological means

Sun, Na; Funke, Susanne A.; Willbold, Dieter (2012)

J Biotechnol 161, 2.
DOI: 10.1016/j.jbiotec.2012.05.019


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A survey of peptides with effective therapeutic potential in Alzheimer's disease rodent models or in human clinical studies

Sun, Na; Funke, Susanne A.; Willbold, Dieter (2012)

Mini-Reviews in Medicinal Chemistry 2012 (12), S. 388-398.


Peer Reviewed

A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis

Mazargui , Honoree; Lévêque , Christian ; Bartnik , Dirk ; Fantini , Jacques ...

Aing Cell 11, 3.
DOI: 10.1111/j.1474-9726.2012.00814.x


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Identification and Characterization of an Aβ Oligomer Precipitating Peptide That May Be Useful to Explore Gene Therapeutic Approaches to Alzheimer Disease

Funke, Susanne A.; Liu, Hongmei ; Sehl, Torsten ; Bartnik , Dirk ; Brener, Oleksandr...

Rejuvenation Research Vol. 15, No. 2 15, 2, S. 144-147..
DOI: 10.1089/rej.2011.1262


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Prof. Dr. Susanne Funke


Hochschule Coburg

Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Friedrich-Streib-Str. 2
96450 Coburg

T 09561317327
aileen.funke[at]hs-coburg.de

ORCID iD: https://orcid.org/0000-0002-1160-8762