Mind-Body-Ansätze
Esch, Tobias; Offenbächer, M.; Kohls, Niko (2014)
In P. Angerer, J. Glaser, H. Gündel, P. Henningsen, C. Lahmann, S. Letzel & D. Nowak (Eds.), Psychische und psychosomatische Gesundheit in der Arbeit (pp. 261 - 268). Landsberg: Ecomed., 261-268.
The evolution of the ribosome biogenesis pathway from a yeast perspective
Ebersberger, Ingo; Simm, Stefan; Leisegang, Matthias; Schmitzberger, Peter; Mirus, Oliver; von Haeseler, Arndt; Bohnsack, Markus; Schleiff, Enrico (2014)
Ebersberger, Ingo; Simm, Stefan; Leisegang, Matthias; Schmitzberger, Peter...
Nucleic Acids Research 42 (3), 1509–1523.
DOI: 10.1093/nar/gkt1137
Open Access Peer Reviewed
Ribosome biogenesis is fundamental for cellular life, but surprisingly little is known about the underlying pathway. In eukaryotes a comprehensive collection of experimentally verified ribosome biogenesis factors (RBFs) exists only for Saccharomyces cerevisiae. Far less is known for other fungi, animals or plants, and insights are even more limited for archaea. Starting from 255 yeast RBFs, we integrated ortholog searches, domain architecture comparisons and, in part, manual curation to investigate the inventories of RBF candidates in 261 eukaryotes, 26 archaea and 57 bacteria. The resulting phylogenetic profiles reveal the evolutionary ancestry of the yeast pathway. The oldest core comprising 20 RBF lineages dates back to the last universal common ancestor, while the youngest 20 factors are confined to the Saccharomycotina. On this basis, we outline similarities and differences of ribosome biogenesis across contemporary species. Archaea, so far a rather uncharted domain, possess 38 well-supported RBF candidates of which some are known to form functional sub-complexes in yeast. This provides initial evidence that ribosome biogenesis in eukaryotes and archaea follows similar principles. Within eukaryotes, RBF repertoires vary considerably. A comparison of yeast and human reveals that lineage-specific adaptation via RBF exclusion and addition characterizes the evolution of this ancient pathway.
The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A.; Willbold, Dieter; Schaal , Heiner (2014)
Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A....
AIDS Research and Therapy 11, 1.
DOI: 10.1186/1742-6405-11-1
Open Access Peer Reviewed
Amyloid aggregation inhibitory mechanism of arginine-rich D-peptides
Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr; Nagel-Steger, Luitgard; Funke, Susanne A.; Willbold, Dieter; Strodel , B. (2014)
Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr...
National Library of Medicine
National Center for Biotechnology Information, 1448-57.
DOI: 10.2174/0929867321666131129122247
Open Access Peer Reviewed
The complexity of vesicle transport factors in plants examined by orthology search
Paul, Puneet; Simm, Stefan; Mirus, Oliver; Scharf, Klaus-Dieter; Fragkostefanakis, Sotirios; Schleiff, Enrico (2014)
Paul, Puneet; Simm, Stefan; Mirus, Oliver; Scharf, Klaus-Dieter...
PloS One 9 (5), e97745.
DOI: 10.1371/journal.pone.0097745
Open Access Peer Reviewed
Vesicle transport is a central process to ensure protein and lipid distribution in eukaryotic cells. The current knowledge on the molecular components and mechanisms of this process is majorly based on studies in Saccharomyces cerevisiae and Arabidopsis thaliana, which revealed 240 different proteinaceous factors either experimentally proven or predicted to be involved in vesicle transport. In here, we performed an orthologue search using two different algorithms to identify the components of the secretory pathway in yeast and 14 plant genomes by using the ’core-set’ of 240 factors as bait. We identified 4021 orthologues and (co-)orthologues in the discussed plant species accounting for components of COP-II, COP-I, Clathrin Coated Vesicles, Retromers and ESCRTs, Rab GTPases, Tethering factors and SNAREs. In plants, we observed a significantly higher number of (co-)orthologues than yeast, while only 8 tethering factors from yeast seem to be absent in the analyzed plant genomes. To link the identified (co-)orthologues to vesicle transport, the domain architecture of the proteins from yeast, genetic model plant A. thaliana and agriculturally relevant crop Solanum lycopersicum has been inspected. For the orthologous groups containing (co-)orthologues from yeast, A. thaliana and S. lycopersicum, we observed the same domain architecture for 79% (416/527) of the (co-)orthologues, which documents a very high conservation of this process. Further, publically available tissue-specific expression profiles for a subset of (co-)orthologues found in A. thaliana and S. lycopersicum suggest that some (co-)orthologues are involved in tissue-specific functions. Inspection of localization of the (co-)orthologues based on available proteome data or localization predictions lead to the assignment of plastid- as well as mitochondrial localized (co-)orthologues of vesicle transport factors and the relevance of this is discussed.
Neuroscience and the Importance of a Neurobioethics: A Reflection upon Fritz Jahr
Giordano, J.; Benedikter, R.; Kohls, Niko (2013)
In A. Muzur & H. M. Sass (Eds.), Fritz Jahr and the Foundations of Global Bioethics - The Future of Integrative Bioethics (Vol. 37, pp. 267 - 280). Münster: Lit. Vol. 37, 267-280.
Spiritual Needs in Patients Suffering from Fibromyalgia
Offenbaecher, M.; Kohls, Niko; Toussaint, L.; Sigl, C.; Winkelmann, A.; Hieblinger, R.; Walther, A.; Büssing, Arndt (2013)
Offenbaecher, M.; Kohls, Niko; Toussaint, L.; Sigl, C.; Winkelmann, A.; Hieblinger, R....
Evidence-based Complementary and Alternative Medicine, 2013, 13. .
Peer Reviewed
Achtsamkeit und achtsamkeitsbasierte Interventionen
Kohls, Niko (2013)
In J. Galuska (Ed.), Bewusstsein: Grundlagen Anwendungen und Entwicklung (pp. 83 - 93). Berlin: MWV., 83-93.
Kontrakturprävention in der Langzeitpflege von Menschen im fortgeschrittenen Alter - Stand der Forschung und Bedeutung für die Praxis.
Herold-Majumdar, A.; Rieß, J.; Daubner, A.; Randzio, O; Kohls, Niko; Müller, M.; Offenbächer, M.; Sauer, S. (2013)
Herold-Majumdar, A.; Rieß, J.; Daubner, A.; Randzio, O; Kohls, Niko; Müller, M....
Gesundheit zwischen Wirtschaft und Demographie. Gemeinsamer Kongress der Deutschen Gesellschaft für Sozialmedizin und Prävention und der Deutschen Gesellschaft für Medizinische Soziologie, 19.9.2013, 358-359.
Peer Reviewed
Achtsamkeit in Organisationen: Vom Stressmanagement über das achtsame Interagieren und Führen zur bewussten Gestaltung von Veränderungsprozessen
Kohls, Niko; Berzlanovich, A.; Sauer, S. (2013)
In W. Kersten & J. Wittmann (Eds.), Kompetenz, Interdisziplinarität und Komplexität in der Betriebswirtschaftslehre (pp. 163-177). Wiesbaden: Springer , 163-177.
Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Old AβPP/PS1 Double Transgenic Mice
van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ; Willbold, Dieter (2013)
van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ...
J Alzheimers Dis. 2013; 34(3): 609–620. , 34 | 609-620.
DOI: 10.3233/JAD-121792
Open Access Peer Reviewed
Neuroethical address of neuroscience and technology to support and foster integration of complementary approaches within healthcare systems: A paradigmatic thesis
Hadley, T.; Kohls, Niko; Plischke , Herbert ; Giordano, J. (2013)
Int Neuroethics Soc Abstr..
Peer Reviewed
The Book – Finding Nazi Loot. Boston Review
Andert, K.; Kohls, Niko (2013)
07/08, 36 – 40., 36-40.
Contractures with special reference in elderly: definition and risk factors – a systematic review with practical implications
Offenbächer, M.; Sauer, S.; Rieß, J.; Müller, M.; Grill, E.; Daubner, A.; Randzio, O; Kohls, Niko; Herold-Majumdar, A. (2013)
Offenbächer, M.; Sauer, S.; Rieß, J.; Müller, M.; Grill, E.; Daubner, A.; Randzio, O...
Disability and Rehabilitation, 36(7), 529-538., 529-538.
Peer Reviewed
Freiheitsentziehende Maßnahmen – Eine spezielle Form von Gewalt in der Pflege
Berzlanovich, A.; Kirsch, S.; Kohls, Niko (2013)
PflegeLeben, 1, 6 – 10..
Freiheit oder Sicherheit? – Verantwortungsvoller Umgang mit freiheitsentziehenden Maßnahmen in der Pflege
Berzlanovich, A.; Kirsch, S.; Kohls, Niko (2013)
Pflege in Bayern 2013; 26:8-10..
Neuroethical Address of Neuroscience and Technology to Support and Foster Integration of Complementary Approaches Within Healthcare Systems: A Paradigmatic Thesis; Abstr Intl Neuroethics Society; 2013.
Hadley, T.; Kohls, Niko; Plischke , Herbert ; Giordano, J. (2013)
A Paradigmatic Thesis; Abstr Intl Neuroethics Society; 2013.
Peer Reviewed
Die Rückgabe eines Buches des protestantischen Gelehrten Wilhelm Wundt aus dem Besitz des enteigneten jüdischen Apothekers Leopold Scheyer an seine Erben - Teil II.
Andert, K.; Kohls, Niko (2013)
Bibliotheksdienst, 47(5), 308 - 314.
Rasch-Analyse des Freiburger Fragebogens zur Achtsamkeit
Sauer, S.; Strobl, C.; Walach, H.; Kohls, Niko (2013)
Diagnostica, 59(2), 86-99..
Peer Reviewed
Exceptional experiences, mindfulness, spiritual practice, and mental distress
Kohls, Niko; Silver, C. F.; Hood, R. W.; Walach, H. (2013)
8th annual congress of the International Society for Complementary Medicine Research (ISCMR), London, 11-13.3.2013 .
Peer Reviewed
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Jakob Hanke
Forschungsreferent
T +49 9561 317 360
jakob.hanke[at]hs-coburg.de