The evolution of the ribosome biogenesis pathway from a yeast perspective

Abstract

Ribosome biogenesis is fundamental for cellular life, but surprisingly little is known about the underlying pathway. In eukaryotes a comprehensive collection of experimentally verified ribosome biogenesis factors (RBFs) exists only for Saccharomyces cerevisiae. Far less is known for other fungi, animals or plants, and insights are even more limited for archaea. Starting from 255 yeast RBFs, we integrated ortholog searches, domain architecture comparisons and, in part, manual curation to investigate the inventories of RBF candidates in 261 eukaryotes, 26 archaea and 57 bacteria. The resulting phylogenetic profiles reveal the evolutionary ancestry of the yeast pathway. The oldest core comprising 20 RBF lineages dates back to the last universal common ancestor, while the youngest 20 factors are confined to the Saccharomycotina. On this basis, we outline similarities and differences of ribosome biogenesis across contemporary species. Archaea, so far a rather uncharted domain, possess 38 well-supported RBF candidates of which some are known to form functional sub-complexes in yeast. This provides initial evidence that ribosome biogenesis in eukaryotes and archaea follows similar principles. Within eukaryotes, RBF repertoires vary considerably. A comparison of yeast and human reveals that lineage-specific adaptation via RBF exclusion and addition characterizes the evolution of this ancient pathway. mehr

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Titel	The evolution of the ribosome biogenesis pathway from a yeast perspective
Medien	Nucleic Acids Research
Heft	3
Band	42
ISSN	1362-4962
Verfasser	Ingo Ebersberger, Prof. Dr. Stefan Simm, Matthias Leisegang, Peter Schmitzberger, Oliver Mirus, Arndt von Haeseler, Markus Bohnsack, Enrico Schleiff
Seiten	1509–1523
Veröffentlichungsdatum	2.2014
Zitation	Ebersberger, Ingo; Simm, Stefan; Leisegang, Matthias; Schmitzberger, Peter; Mirus, Oliver; von Haeseler, Arndt; Bohnsack, Markus; Schleiff, Enrico (2014): The evolution of the ribosome biogenesis pathway from a yeast perspective. Nucleic Acids Research 42 (3), 1509–1523. DOI: 10.1093/nar/gkt1137