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QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Abstract
Strong evidence exists for a central role of amyloid ß-protein (Aß)
oligomers in the pathogenesis of Alzheimer`s disease. We have developed a
fast, reliable and robust in vitro assay, termed QIAD, to quantify the
effect of any compound on the Aß aggregate size distribution. Applying
QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the
benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and
its tandem version D3D3 on Aß aggregation. The predictive power of the
assay for in vivo efficacy is demonstrated by comparing the oligomer
elimination efficiency of D3 and D3D3 with their treatment effects in
animal models of Alzheimer´s disease.
Mehr zum Titel
| Titel | QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers |
|---|---|
| Medien | Scientific Reports |
| Band | 2015 / 5 |
| Verfasser | Oleksandr Brener, Tina Dunkelmann, Lothar Gremer, Thomas van Groen, Ewa A. Mirecka, Inga Kadish, Antje Willuweit, Janine Kutzsche, Dagmar Jürgens, Stephan Rudolph, Markus Tusche, Patrick Bongen, Jörg Pietruszka, Filipp Oesterhelt, Karl-Josef Langen, Hans-Ulrich Demuth, Arnold Janssen, Wolfgang Hoyer, Prof. Dr. Susanne Funke, Luitgard Nagel-Steger, Dieter Willbold |
| Seiten | 13222 |
| Veröffentlichungsdatum | 23.09.2015 |
| Zitation | Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015): QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers. Scientific Reports 2015 / 5, 13222. DOI: 10.1038/srep13222 |