Evaluation of natural-based internal insulation systems in historic buildings through a holistic approach
Bottino-Leone, Dario; Larcher, Marco; Herrera-Avellanosa, Daniel; Haas, Franziska; Troi, Alexandra (2019)
Bottino-Leone, Dario; Larcher, Marco; Herrera-Avellanosa, Daniel; Haas, Franziska...
Energy 181, 521–531.
DOI: 10.1016/j.energy.2019.05.139
Open Access Peer Reviewed
Co-orthologues of ribosome biogenesis factors in A. thaliana are differentially regulated by transcription factors
Kovacevic, Jelena; Palm, Denise; Jooss, Domink; Bublak, Daniela; Simm, Stefan; Schleiff, Enrico (2019)
Kovacevic, Jelena; Palm, Denise; Jooss, Domink; Bublak, Daniela; Simm, Stefan...
Plant Cell Reports 38 (8), 937–949.
DOI: 10.1007/s00299-019-02416-y
Open Access Peer Reviewed
Different genes coding for one ribosome biogenesis factor are differentially expressed and are likely under the control of distinct transcription factors, which contributes to the regulatory space for ribosome maturation. Maturation of ribosomes including rRNA processing and modification, rRNA folding and ribosome protein association requires the function of many ribosome biogenesis factors (RBFs). Recent studies document plant-specific variations of the generally conserved process of ribosome biogenesis. For instance, distinct rRNA maturation pathways and intermediates have been identified, the existence of plant specific RBFs has been proposed and several RBFs are encoded by multiple genes. The latter in combination with the discussed ribosome heterogeneity points to a possible function of the different proteins representing one RBF in diversification of ribosomal compositions. Such factor-based regulation would require a differential regulation of their expression, may be even controlled by different transcription factors. We analyzed the expression profiles of genes coding for putative RBFs and transcription factors. Most of the genes coding for RBFs are expressed in a comparable manner, while different genes coding for a single RBF are often differentially expressed. Based on a selected set of genes we document a function of the transcription factors AtMYC1, AtMYC2, AtbHLH105 and AtMYB26 on the regulation of different RBFs. Moreover, on the example of the RBFs LSG1 and BRX1, both encoded by two genes, we give a first hint on a differential transcription factor dependence of expression. Consistent with this observation, the phenotypic analysis of RBF mutants suggests a relation between LSG1-1 and BRX1-1 expression and the transcription factor MYC1. In summary, we propose that the multiple genes coding for one RBF are required to enlarge the regulatory space for ribosome biogenesis.
Metadisziplinäre Ästhetik: Das Ornamentale
Heinrich, Michael (2019)
Vortrag, Decor und Decorum: Natur und Geist in Kunst und Philosophie, Oberseminar Lehrstuhl Philosophie II, Universität Bamberg.
Bewusstsein für Prävention und Gesundheitsförderung – Bedeutung für die Behandlung chronischer Erkrankungen
Röhrich, Christina; Kohls, Niko (2019)
Zeitschrift Herzblick – Das Merlin-AHF Projekt, Herausgeber Herzkind e. V. Sonderausgabe 3/2019.
Perceived stigma and health-related quality of life in the working uninsured: Does thwarted belongingness play a role? Stigma and Health, 4(1), 1-10.
Hirsch, J. K.; Sirios , F. ; Visser, P.; Brooks, B.; Kohls, Niko; Offenbacher, M.; Toussaint, L. (2019)
Hirsch, J. K.; Sirios , F. ; Visser, P.; Brooks, B.; Kohls, Niko; Offenbacher, M....
Perceived stigma and health-related quality of life in the working uninsured: Does thwarted belongingness play a role? Stigma and Health..
Open Access Peer Reviewed
FRI0693 Resilience traits in a large cohort of patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA) and fibromyalgia (FM)
Toussaint, L.; Kohls, Niko; Hanshans, C.; Vallejo, M.; Rivera, J.; Sirois, F.; Hirsch, J. K.; Untner, J.; Hölzl, B.; Gaisberger, M.; Offenbächer, M. (2019)
Toussaint, L.; Kohls, Niko; Hanshans, C.; Vallejo, M.; Rivera, J.; Sirois, F....
Annals of the Rheumatic Diseases, 78(Suppl 2), 1046-1046. Retrieved from https://ard.bmj.com/content/annrheumdis/78/Suppl_2/1046.1.full.pdf. doi:10.1136/annrheumdis-2019-eular.5361 .
Peer Reviewed
FRI0694 Self-reported sleeping problems and fatigue in large cohort of patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA) and fibromyalgia (FM)
Offenbächer, M.; Kohls, Niko; Hanshans, Christian ; Vallejo, M.; Rivera, J.; Sirios , F. ; Hirsch, J. K.; Untner, J.; Hölzl, B.; Gaisberger, M.; Toussaint, L. (2019)
Offenbächer, M.; Kohls, Niko; Hanshans, Christian ; Vallejo, M.; Rivera, J....
Annals of the Rheumatic Diseases, 78(Suppl 2), 1046-1046. Retrieved from https://ard.bmj.com/content/annrheumdis/78/Suppl_2/1046.2.full.pdf. doi:10.1136/annrheumdis-2019-eular.4912.
Open Access Peer Reviewed
Sicherheit statt Freiheit?! - Einsatz freiheitsentziehender Maßnahmen (FEM) in der Pflege von Menschen mit Demenz
Berzlanovich, A.; Kohls, Niko (2019)
In H. Walach & M. Loef (Eds.), Demenz – Prävention und Therapie (pp. 439 - 448). Essen: KVC., 439-448.
SAT0680 Educational needs of a large cohort of patients with different rheumatic and musculoskeletal diseases attending a health facility in Austria
Offenbaecher, M.; Toussaint, L.; Kohls, Niko; Hanshans, Christian ; Vallejo, M.; Rivera, J.; Sirios , F. ; Hirsch, J. K.; Untner, J.; Hölzl, B.; Gaisberger, M.; Ndosi, M. (2019)
Offenbaecher, M.; Toussaint, L.; Kohls, Niko; Hanshans, Christian ; Vallejo, M....
Annals of the Rheumatic Diseases 2019 / 78, 1442.
Peer Reviewed
Stress im Studium
Nagel, Andreas; John, Dennis; Kohls, Niko (2019)
Moment by Moment..
Bedeutung von Prävention, Gesundheitsförderung und die Rolle des salutogenetischen Denkens in der Behandlung von chronischen Erkrankungen
Röhrich, Christina; Kohls, Niko (2019)
Journal für angeborene Herzfehler, Band 7 7.
Regulation of two GTPases Toc159 and Toc34 in the translocon of the outer envelope of chloroplasts
Wiesemann, Katharina; Simm, Stefan; Mirus, Oliver; Ladig, Roman; Schleiff, Enrico (2019)
Biochimica Et Biophysica Acta. Proteins and Proteomics 1867 (6), 627–636.
DOI: 10.1016/j.bbapap.2019.01.002
Open Access Peer Reviewed
The GTPases Toc159 and Toc34 of the translocon of the outer envelope of chloroplasts (TOC) are involved in recognition and transfer of precursor proteins at the cytosolic face of the organelle. Both proteins engage multiple interactions within the translocon during the translocation process, including dimeric states of their G-domains. The units of the Toc34 homodimer are involved in the recognition of the transit peptide representing the translocation signal of precursor proteins. This substrate recognition is part of the regulation of the GTPase cycle of Toc34. The Toc159 monomer and the Toc34 homodimer recognize the transit peptide of the small subunit of Rubisco at the N- and at the C-terminal region, respectively. Analysis of the transit peptide interaction by crosslinking shows that the heterodimer between both G-domains binds pSSU most efficiently. While substrate recognition by Toc34 homodimer was shown to regulate nucleotide exchange, we provide evidence that the high activation energy of the GTPase Toc159 is lowered by substrate recognition. The nucleotide affinity of Toc34G homodimer and Toc159G monomer are distinct, Toc34G homodimer recognizes GDP and Toc159G GTP with highest affinity. Moreover, the analysis of the nucleotide association rates of the monomeric and dimeric receptor units suggests that the heterodimer has an arrangement distinct from the homodimer of Toc34. Based on the biochemical parameters determined we propose a model for the order of events at the cytosolic side of TOC. The molecular processes described by this hypothesis range from transit peptide recognition to perception of the substrate by the translocation channel.
Mindful Leader Development: How Leaders Experience the Effects of Mindfulness Training on Leader Capabilities
Rupprecht, S.; Falke, P.; Kohls, Niko; Tamdjidi, C.; Wittmann, M.; Kersemaekers, W. (2019)
Frontiers in Psychology, 10(1081). doi:10.3389/fpsyg.2019.01081.
DOI: 10.3389/fpsyg.2019.01081
Peer Reviewed
Experimentelle Betrachtung der Wärmeübertragung durch instationäre freie Konvektion an der vertikalen Platte
Schaub, Michael (2019)
Fortschritt-Berichte VDI, Düsseldorf, 2019. Zugl.: Technische Universität Berlin, Dissertation, 2019. 19 (162).
DOI: 10.14279/depositonce-8706
Open Access
The sizing of energy storages or how valuable is the last step?
Floß, Alexander; Schaub, Michael (2019)
Advances in Building Energy Research 14 (03), 355-371.
DOI: 10.1080/17512549.2019.1588166
Peer Reviewed
Von der Psychologie des Horizontes zu den epistemologischen Horizonten der akademischen Psychologie
Kohls, Niko (2019)
In B. Frischmann & C. Holtorf (Eds.), Über den Horizont - Standorte, Grenzen und Perspektiven (pp. 149 - 164): De Gruyter., 149-164.
Experimental investigation of heat transfer by unsteady natural convection at a vertical flat plate
Schaub, Michael; Kriegel, Martin; Brandt, Stefan (2019)
International Journal of Heat and Mass Transfer 136, 1186-1198.
DOI: 10.1016/j.ijheatmasstransfer.2019.03.089
Peer Reviewed
The repressor and co-activator HsfB1 regulates the major heat stress transcription factors in tomato
Fragkostefanakis, Sotirios; Simm, Stefan; El-Shershaby, Asmaa; Hu, Yangjie; Bublak, Daniela; Mesihovic, Anida; Darm, Katrin; Mishra, Shravan; Tschiersch, Bettina; Theres, Klaus; Scharf, Christian; Schleiff, Enrico; Scharf, Klaus-Dieter (2019)
Fragkostefanakis, Sotirios; Simm, Stefan; El-Shershaby, Asmaa; Hu, Yangjie...
Plant, Cell & Environment 42 (3), 874–890.
DOI: 10.1111/pce.13434
Open Access Peer Reviewed
Plants code for a multitude of heat stress transcription factors (Hsfs). Three of them act as central regulators of heat stress (HS) response in tomato (Solanum lycopersicum). HsfA1a regulates the initial response, and HsfA2 controls acquired thermotolerance. HsfB1 is a transcriptional repressor but can also act as co-activator of HsfA1a. Currently, the mode of action and the relevance of the dual function of HsfB1 remain elusive. We examined this in HsfB1 overexpression or suppression transgenic tomato lines. Proteome analysis revealed that HsfB1 overexpression stimulates the co-activator function of HsfB1 and consequently the accumulation of HS-related proteins under non-stress conditions. Plants with enhanced levels of HsfB1 show aberrant growth and development but enhanced thermotolerance. HsfB1 suppression has no significant effect prior to stress. Upon HS, HsfB1 suppression strongly enhances the induction of heat shock proteins due to the higher activity of other HS-induced Hsfs, resulting in increased thermotolerance compared with wild-type. Thereby, HsfB1 acts as co-activator of HsfA1a for several Hsps, but as a transcriptional repressor on other Hsfs, including HsfA1b and HsfA2. The dual function explains the activation of chaperones to enhance protection and regulate the balance between growth and stress response upon deviations from the homeostatic levels of HsfB1.
Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing
Palm, Denise; Streit, Deniz; Shanmugam, Thiruvenkadam; Weis, Benjamin; Ruprecht, Maike; Simm, Stefan; Schleiff, Enrico (2019)
Palm, Denise; Streit, Deniz; Shanmugam, Thiruvenkadam; Weis, Benjamin; Ruprecht, Maike...
Nucleic Acids Research 47 (4), 1880–1895.
DOI: 10.1093/nar/gky1261
Open Access Peer Reviewed
rRNA processing and assembly of ribosomal proteins during maturation of ribosomes involve many ribosome biogenesis factors (RBFs). Recent studies identified differences in the set of RBFs in humans and yeast, and the existence of plant-specific RBFs has been proposed as well. To identify such plant-specific RBFs, we characterized T-DNA insertion mutants of 15 Arabidopsis thaliana genes encoding nuclear proteins with nucleotide binding properties that are not orthologues to yeast or human RBFs. Mutants of nine genes show an altered rRNA processing ranging from inhibition of initial 35S pre-rRNA cleavage to final maturation events like the 6S pre-rRNA processing. These phenotypes led to their annotation as ’involved in rRNA processing’ - IRP. The irp mutants are either lethal or show developmental and stress related phenotypes. We identified IRPs for maturation of the plant-specific precursor 5’-5.8S and one affecting the pathway with ITS2 first cleavage of the 35S pre-rRNA transcript. Moreover, we realized that 5’-5.8S processing is essential, while a mutant causing 6S accumulation shows only a weak phenotype. Thus, we demonstrate the importance of the maturation of the plant-specific precursor 5’-5.8S for plant development as well as the occurrence of an ITS2 first cleavage pathway in fast dividing tissues.
Trying to be perfect in an imperfect world: A person-centred test of perfectionism and health in fibromyalgia patients versus healthy controls
Sirois, F. M.; Toussaint, L.; Hirsch, J. K.; Kohls, Niko; Weber, Annemarie; Offenbächer, M. (2019)
Sirois, F. M.; Toussaint, L.; Hirsch, J. K.; Kohls, Niko; Weber, Annemarie...
Personality and Individual Differences 2019 / 137, 27–32.
DOI: 10.1016/j.paid.2018.08.005
Peer Reviewed
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