Quantitation of Amyloid-β oligomers in human body fluids for Alzheimer’s disease early diagnosis or therapy monitoring
Funke, Susanne A.; Willbold, Dieter (2016)
Alzheimer's diagnosis, S. 1-24.
DOI: 10.3233/JAD-151029
Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity
Rudolph, Stephan; Klein, Antonia Nicole ; Tusche, Markus; Schlosser, Christine ; Elfgen , Anne; Brener, Oleksandr; Teunisssen , Charlotte; Gremer, Lothar; Funke, Susanne A.; Kutzsche, Janine; Willbold, Dieter (2016)
Rudolph, Stephan; Klein, Antonia Nicole ; Tusche, Markus; Schlosser, Christine ...
PLOS ONE 11, 2.
DOI: 10.1371/journal.pone.0147470
Open Access Peer Reviewed
QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015)
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A....
Scientific Reports 5, 13222.
DOI: 10.1038/srep13222
Open Access Peer Reviewed
Structure characterization of unexpected covalent O-sulfonation and ion-pairing on an extremely hydrophilic peptide with CE-MS and FT-ICR-MS
Pattky, Martin ; Nicolardi , Simone ; Santiago-Schübel , Beatrix ; Sydes , Daniel ; van der Burgt , Yuri E. M.; Klein, Antonia Nicole ; Jiang , Nan; Mohrlüder, Jeannine ; Hänel , Karen ; Kutzsche, Janine; Funke, Susanne A.; Willbold, Dieter; Willbold , S.; Huhn, C. (2015)
Pattky, Martin ; Nicolardi , Simone ; Santiago-Schübel , Beatrix ; Sydes , Daniel ...
Analytical and Bioanalytical Chemistry volume 407 407, 6637-55 (22).
DOI: 10.1007/s00216-015-8826-8
Open Access Peer Reviewed
Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-Vaccines
Mandler, Markus; Santic, Radmila ; Gruber , Petra; Cinar, Yeliz ; Pichler, Dagmar ; Funke, Susanne A.; Willbold, Dieter; Schneeberger , Achim ; Schmidt , Walter; Mattner , Frank (2015)
Mandler, Markus; Santic, Radmila ; Gruber , Petra; Cinar, Yeliz ; Pichler, Dagmar ...
PLOS ONE.
DOI: 10.1371/journal.pone.0115237
Open Access Peer Reviewed
QIAD assay for quantitating a compound`s efficacy in elimination of toxic Aß oligomers
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A.; Kadish, Inga; Willuweit, Antje; Kutzsche, Janine; Jürgens, Dagmar; Rudolph, Stephan; Tusche, Markus; Bongen, Patrick; Pietruszka, Jörg; Oesterhelt, Filipp; Langen, Karl-Josef; Demuth, Hans-Ulrich; Janssen, Arnold; Hoyer, Wolfgang; Funke, Susanne A.; Nagel-Steger, Luitgard; Willbold, Dieter (2015)
Brener, Oleksandr; Dunkelmann, Tina; Gremer, Lothar; van Groen, Thomas; Mirecka, Ewa A....
Scientific reports 2015 5, S. 13222.
DOI: 10.1038/srep13222
Peer Reviewed
Strong evidence exists for a central role of amyloid ß-protein (Aß) oligomers in the pathogenesis of Alzheimer`s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aß aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAß3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aß aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.
Detection and Quantitation of Amyloid-β Aggregates in Body Fluids may be Suitable for Early Diagnosis of Alzheimer’s Disease
Funke, Susanne A.; Birkmann, Eva; Willbold, Dieter (2014)
Advances in Alzheimer's Research
2.
DOI: 10.2174/9781608058525114020013
The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A.; Willbold, Dieter; Schaal , Heiner (2014)
Widera , Marek ; Klein, Antonia Nicole ; Cinar, Yeliz ; Funke, Susanne A....
AIDS Research and Therapy 11, 1.
DOI: 10.1186/1742-6405-11-1
Open Access Peer Reviewed
Amyloid aggregation inhibitory mechanism of arginine-rich D-peptides
Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr; Nagel-Steger, Luitgard; Funke, Susanne A.; Willbold, Dieter; Strodel , B. (2014)
Olubiyi , O. O. ; Frenzel , Oliver ; Bartnik , Dirk ; Glück , J. M. ; Brener, Oleksandr...
National Library of Medicine
National Center for Biotechnology Information, 1448-57.
DOI: 10.2174/0929867321666131129122247
Open Access Peer Reviewed
Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Old AβPP/PS1 Double Transgenic Mice
van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ; Willbold, Dieter (2013)
van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ...
J Alzheimers Dis. 2013; 34(3): 609–620. , 34, S. 609-620.
DOI: 10.3233/JAD-121792
Open Access Peer Reviewed
Characterization of a single-chain variable fragment recognizing a linear epitope of Aß: A biotechnical tool for studies on Alzheimer's disease?
Dornieden, Silke; Müller-Schiffmann, A.; Sticht, H.; Cinar, Yeliz ; Wördehoff, M.; Korth , C.; Funke, Susanne A.; Willbold, Dieter (2013)
Dornieden, Silke; Müller-Schiffmann, A.; Sticht, H.; Cinar, Yeliz ; Wördehoff, M....
Lawrence, Kan. PLoS 2013 , 8, S. e59820.
DOI: 10.1371/journal.pone.0059820
Peer Reviewed
The amyloid-β oligomer count in cerebrospinal fluid is a biomarker for Alzheimer's disease
Wang-Dietrich , Lei ; Funke, Susanne A.; Kühlbach , Katja ; Wang , Kun; Besmehn, Astrid ; Willbold , S.; Cinar, Yeliz ; Bannach , Oliver; Birkmann, Eva; Willbold, Dieter (2013)
Wang-Dietrich , Lei ; Funke, Susanne A.; Kühlbach , Katja ; Wang , Kun...
National Library of Medicine
National Center for Biotechnology Information, 34.
DOI: 10.3233/JAD-122047.
Open Access Peer Reviewed
Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy
Sun, Na; Hartmann, Rudolf ; Lecher, Justin ; Stoldt , Matthias ; Funke, Susanne A.; Gremer, Lothar; Ludwig , Hans-Henning ; Demuth, Hans-Ulrich; Kleinschmidt , Martin ; Willbold, Dieter (2012)
Sun, Na; Hartmann, Rudolf ; Lecher, Justin ; Stoldt , Matthias ; Funke, Susanne A....
J Pept Sci
2012 Nov;18(11):691-5 2012, 18.
DOI: 10.1002/psc.2456
Open Access Peer Reviewed
Mirror image phage display--generating stable therapeutically and diagnostically active peptides with biotechnological means
Sun, Na; Funke, Susanne A.; Willbold, Dieter (2012)
J Biotechnol 161, 2.
DOI: 10.1016/j.jbiotec.2012.05.019
Open Access Peer Reviewed
A survey of peptides with effective therapeutic potential in Alzheimer's disease rodent models or in human clinical studies
Sun, Na; Funke, Susanne A.; Willbold, Dieter (2012)
Mini-Reviews in Medicinal Chemistry 2012 (12), S. 388-398.
Peer Reviewed
A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis
Mazargui , Honoree; Lévêque , Christian ; Bartnik , Dirk ; Fantini , Jacques ; Melone, Mariarosa A.B. ; Funke, Susanne A.; Willbold, Dieter; Perrone , Lorena (2012)
Mazargui , Honoree; Lévêque , Christian ; Bartnik , Dirk ; Fantini , Jacques ...
Aing Cell
11, 3.
DOI: 10.1111/j.1474-9726.2012.00814.x
Open Access Peer Reviewed
Identification and Characterization of an Aβ Oligomer Precipitating Peptide That May Be Useful to Explore Gene Therapeutic Approaches to Alzheimer Disease
Funke, Susanne A.; Liu, Hongmei ; Sehl, Torsten ; Bartnik , Dirk ; Brener, Oleksandr; Nagel-Steger, Luitgard; Wiesehan , Katja ; Willbold, Dieter (2012)
Funke, Susanne A.; Liu, Hongmei ; Sehl, Torsten ; Bartnik , Dirk ; Brener, Oleksandr...
Rejuvenation Research Vol. 15, No. 2
15, 2, S. 144-147..
DOI: 10.1089/rej.2011.1262
Open Access Peer Reviewed
Detection of α-synuclein aggregates by fluorescence microscopy
Hübinger, S. ; Bannach , Oliver; Funke, Susanne A.; Funke, Susanne A.; Willbold, Dieter; Birkmann, Eva (2012)
Hübinger, S. ; Bannach , Oliver; Funke, Susanne A.; Funke, Susanne A....
Rejuvenation Res. 15, 15, 2, S. 213- 216..
DOI: 10.1089/rej.2011.1288
Open Access Peer Reviewed
Development of a small D-enantiomeric Alzheimer's amyloid-β binding peptide ligand for future in vivo imaging applications
Funke, Susanne A.; Bartnik , Dirk ; Glück , J. M. ; Piorkowska , Kasia ; Wiesehan , Katja ; Weber, Urs; Gulyas , Balazs ; Halldin , Christer; Pfeifer, Andrea ; Sprenger, Christian ; Muhs , Andreas ; Willbold, Dieter (2012)
Funke, Susanne A.; Bartnik , Dirk ; Glück , J. M. ; Piorkowska , Kasia ...
PLOS One , 7.
DOI: 10.1371/journal.pone.0041457
Open Access Peer Reviewed
Treatment with Aβ42 binding D-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic mice
van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ; Willbold, Dieter (2012)
van Groen, Thomas; Kadish, Inga; Funke, Susanne A.; Bartnik , Dirk ...
Advances in Protein Chemistry and Structural Biology
88, S. 133-152.
DOI: 10.1016/B978-0-12-398314-5.00005-2
Open Access
Prof. Dr. Susanne Funke
Hochschule Coburg
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Friedrich-Streib-Str. 2
96450 Coburg
T 09561317327 aileen.funke[at]hs-coburg.de
ORCID iD: https://orcid.org/0000-0002-1160-8762