Storytelling als Prüfung – Mit Emotionen Wissen schaffen
Phillips, Mark (2022)
Prüfung hoch drei. Didaktik. Technik. Vernetzung 2022.
Open Access
Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine; Geyer, Joachim; Simm, Stefan; Tzvetkov, Mladen (2022)
Meyer, Marleen; Falk, Simon; Römer, Sarah; Prinzinger, Clarissa; Tacke, Sabine...
International Journal of Molecular Sciences 23 (9), 5100.
DOI: 10.3390/ijms23095100
Open Access Peer Reviewed
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned and the publicly available RNA-Seq sequences differed from the annotated exon-intron structure of OCT1 in the dog genome CanFam3.1. An additional exon between exons 2 and 3 was identified and confirmed by sequencing in six additional dog breeds. Next, dog OCT1 and OCT2 were stably overexpressed in HEK293 cells and the transport kinetics of five drugs were analyzed. We observed strong differences in the transport kinetics between dog and human orthologs. Dog OCT1 transported fenoterol with 12.9-fold higher capacity but 14.3-fold lower affinity (higher KM) than human OCT1. Human OCT1 transported ipratropium with 5.2-fold higher capacity but 8.4-fold lower affinity than dog OCT1. Compared to human OCT2, dog OCT2 showed 10-fold lower transport of fenoterol and butylscopolamine. In conclusion, the functional characterization of dog OCT1 and OCT2 reported here may have implications when using dogs as pre-clinical models as well as for drug therapy in dogs.
Healing Architecture: Wenn die Umgebung heilend auf den Körper und Seele wirken kann
Heinrich, Michael (2022)
VHS Coburg.
Emission of CO2 and CH4 From 13 Deadwood Tree Species Is Linked to Tree Species Identity and Management Intensity in Forest and Grassland Habitats
Kipping, Lydia; Gossner, Martin M.; Koschorreck, Matthias; Muszynski, Sarah; Maurer, Florian; Weisser, Wolfgang W.; Noll, Matthias (2022)
Kipping, Lydia; Gossner, Martin M.; Koschorreck, Matthias; Muszynski, Sarah...
Global Biogeochemical Cycles 2022 (36), 5.
DOI: 10.1029/2021GB007143
Open Access Peer Reviewed
Open-label Placebos (Journal club)
Meißner, Karin; Olliges, Elisabeth; Weimer, K.; Beissner, F. (2022)
Complementary Medicine Research 29 (2), 23-29.
DOI: 10.1159/000524073
Open Access
More than you can see: Unraveling the ecology and biodiversity of lichenized fungi associated with leaves and needles of 12 temperate tree species using high throughput sequencing
Tanunchai, Benjawan; Schroeter , Simon Andreas; Ji, Li; Wahdan, S. F. M.; Hossen, Shakhawat; Lehnert , A.-S.; Grünberg, H.; Gleixner, Gerd; Buscot, F.; Schulze, Ernst-Detlef ; Noll, Matthias; Purahong, W. (2022)
Tanunchai, Benjawan; Schroeter , Simon Andreas; Ji, Li; Wahdan, S. F. M....
Frontiers in Microbiology 13, 90753.
DOI: 10.3389/fmicb.2022.907531
Open Access Peer Reviewed
Interactions Between High Load of a Bio-based and Biodegradable Plastic and Nitrogen Fertilizer Affect Plant Biomass and Health: A Case Study with Fusarium solani and Mung Bean (Vigna radiata L.)
Scheid, Sarah-Maria ; Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Buscot , F.; Noll, Matthias; Purahong , W. (2022)
Scheid, Sarah-Maria ; Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Buscot , F....
Brief Communication.
DOI: 10.1007/s10924-022-02435-z
Open Access
Leptolyngbya sp. NIVA-CYA 255, a Promising Candidate for Poly(3-hydroxybutyrate) Production under Mixotrophic Deficiency Conditions
Kettner, Alexander; Noll, Matthias; Griehl, C. (2022)
MDPI Biomolecules 2022 (504), 12.
DOI: 10.3390/biom12040504
Open Access Peer Reviewed
Psychosomatic interventions for functional post-COVID syndromes. Open-label placebo and paced breathing as patient-tailored interventions
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva; Jarczok, Marc N.; Weimer, K. (2022)
Hamberger, Jens; Loew, T.; Meißner, Karin; Beschoner, Petra; Roder, Eva...
Poster presentation A1634, 79th Annual Scientific Meeting of the American Psychosomatic Society (APS), March 23-26, 2022, Long Beach, California, US 84 (5), A1-A153.
DOI: 10.1097/PSY.0000000000001095
Peer Reviewed
Podcast Inside Hochschule
Arbeiter, Georg (2022)
Podcast Radio Eins.
Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela; Grundhoff, Adam; Wegwitz, Florian ; Kalkhof, Stefan; Hildebrand, Janosch (2022)
Wester (geb. Hoen), Laura; Rudisch , Christoph ; Wick , Michael ; Indenbirken , Daniela...
Cells 11 (6), 959.
DOI: 10.3390/cells11060959
Open Access Peer Reviewed
Cross-kingdom interactions and functional patterns of active microbiota matter in governing deadwood decay
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M.; Jonas, Malter; Buscot, F.; Noll, Matthias (2022)
Purahong, W.; Tanunchai, Benjawan; Muszynski, Sarah; Maurer, Florian; Wahdan, S. F. M....
Proceedings of the Royal Society Biological Sciences 2022, 20220130.
DOI: 10.1098/rspb.2022.0130
Open Access Peer Reviewed
Wohnen in der Generation Z: Das neue Biedermeier?
Heinrich, Michael (2022)
Bayern 2, Bayerischer Rundfunk, 2022.
Von der „Lebensstilschluderei“ über die Gesundheitskompetenz zur agilen und resilienten Organisation Online-Keynote „Asset Gesundheit: Die unternehmerischen Vorteile. Die eigentliche Idee von BGM und warum es sich rechnet.
Kohls, Niko (2022)
Unternehmerforum Ruhr, Keynote, Online-Event.
Fahrerlose Shuttles im öffentlichen Personennahverkehr: Akzeptanz und Einstellung in der Bevölkerung
Wilde, Mathias; Rebhan , Jakob (2022)
Standort - Zeitschrift für Angewandte Geographie 46 (1), 2-8.
DOI: 10.1007/s00548-021-00746-2
Open Access Peer Reviewed
Resilienz, Schattenachtsamkeit und Spiritualität - Gedanken zur Dialektik von Bewusstseinskultivierung in Krisenzeiten
Kohls, Niko (2022)
Report Psychologie 47 (3), 6-10.
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie; Müller-Kuller, Uta; Gutfreund, Niklas; Riegel, Kristina; Smits, Jos; Schleiff, Enrico; Rajalingam, Krishnaraj; Zhou, Huiqing; Simm, Stefan; Dötsch, Volker (2022)
Fester, Niclas; Zielonka, Elisabeth; Goldmann, Jakob; Frombach, Ann-Sophie...
Cell Death & Disease 13 (3), 204.
DOI: 10.1038/s41419-022-04659-2
Open Access Peer Reviewed
Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore, not only detrimental for the individual but affect the entire species. In oocytes, the surveillance of the structural integrity of the DNA is maintained by the p53 family member TAp63α. The TAp63α protein is highly expressed in a closed and inactive state and gets activated to the open conformation upon the detection of DNA damage, in particular DNA double-strand breaks. To understand the cellular response to DNA damage that leads to the TAp63α triggered oocyte death we have investigated the RNA transcriptome of oocytes following irradiation at different time points. The analysis shows enhanced expression of pro-apoptotic and typical p53 target genes such as CDKn1a or Mdm2, concomitant with the activation of TAp63α. While DNA repair genes are not upregulated, inflammation-related genes become transcribed when apoptosis is initiated by activation of STAT transcription factors. Furthermore, comparison with the transcriptional profile of the ΔNp63α isoform from other studies shows only a minimal overlap, suggesting distinct regulatory programs of different p63 isoforms.
Auf dem Weg zu Energieeffizienter Künstlicher Intelligenz: Welche Energieeinsparpotentiale bieten KI-Anwendungen?
Babilon, Linda; Kratochwill, Lisa; Müller, Karsten; Rischke, Roman; Samek, Wojciech; Stabernack, Benno; Steinert, Fritjof (2022)
Babilon, Linda; Kratochwill, Lisa; Müller, Karsten; Rischke, Roman; Samek, Wojciech...
Deutsche-Energie-Agentur (Hrsg.).
Open Access
Diversität und Teilhabe in Kunst und Kultur
Gross, Hellen (2022)
Kulturkonferenz des Landes Nordrhein-Westfalen 2022, 22. Februar 2022, virtuell .
Greater than the sum of the books. How society and its conceptions of man is reflected in architecture.
Heinrich, Michael (2022)
Shrines of Wisdom. The Sacralization of Knowledge: A Core Dynamics of the Western Paradigm of Progress and its Architectural Expression within the College Topos. Jesus College, Cambridge.