The repressor and co-activator HsfB1 regulates the major heat stress transcription factors in tomato
Fragkostefanakis, Sotirios; Simm, Stefan; El-Shershaby, Asmaa; Hu, Yangjie; Bublak, Daniela; Mesihovic, Anida; Darm, Katrin; Mishra, Shravan; Tschiersch, Bettina; Theres, Klaus; Scharf, Christian; Schleiff, Enrico; Scharf, Klaus-Dieter (2019)
Fragkostefanakis, Sotirios; Simm, Stefan; El-Shershaby, Asmaa; Hu, Yangjie...
Plant, Cell & Environment 42 (3), 874–890.
DOI: 10.1111/pce.13434
Open Access Peer Reviewed
Plants code for a multitude of heat stress transcription factors (Hsfs). Three of them act as central regulators of heat stress (HS) response in tomato (Solanum lycopersicum). HsfA1a regulates the initial response, and HsfA2 controls acquired thermotolerance. HsfB1 is a transcriptional repressor but can also act as co-activator of HsfA1a. Currently, the mode of action and the relevance of the dual function of HsfB1 remain elusive. We examined this in HsfB1 overexpression or suppression transgenic tomato lines. Proteome analysis revealed that HsfB1 overexpression stimulates the co-activator function of HsfB1 and consequently the accumulation of HS-related proteins under non-stress conditions. Plants with enhanced levels of HsfB1 show aberrant growth and development but enhanced thermotolerance. HsfB1 suppression has no significant effect prior to stress. Upon HS, HsfB1 suppression strongly enhances the induction of heat shock proteins due to the higher activity of other HS-induced Hsfs, resulting in increased thermotolerance compared with wild-type. Thereby, HsfB1 acts as co-activator of HsfA1a for several Hsps, but as a transcriptional repressor on other Hsfs, including HsfA1b and HsfA2. The dual function explains the activation of chaperones to enhance protection and regulate the balance between growth and stress response upon deviations from the homeostatic levels of HsfB1.
Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing
Palm, Denise; Streit, Deniz; Shanmugam, Thiruvenkadam; Weis, Benjamin; Ruprecht, Maike; Simm, Stefan; Schleiff, Enrico (2019)
Palm, Denise; Streit, Deniz; Shanmugam, Thiruvenkadam; Weis, Benjamin; Ruprecht, Maike...
Nucleic Acids Research 47 (4), 1880–1895.
DOI: 10.1093/nar/gky1261
Open Access Peer Reviewed
rRNA processing and assembly of ribosomal proteins during maturation of ribosomes involve many ribosome biogenesis factors (RBFs). Recent studies identified differences in the set of RBFs in humans and yeast, and the existence of plant-specific RBFs has been proposed as well. To identify such plant-specific RBFs, we characterized T-DNA insertion mutants of 15 Arabidopsis thaliana genes encoding nuclear proteins with nucleotide binding properties that are not orthologues to yeast or human RBFs. Mutants of nine genes show an altered rRNA processing ranging from inhibition of initial 35S pre-rRNA cleavage to final maturation events like the 6S pre-rRNA processing. These phenotypes led to their annotation as ’involved in rRNA processing’ - IRP. The irp mutants are either lethal or show developmental and stress related phenotypes. We identified IRPs for maturation of the plant-specific precursor 5’-5.8S and one affecting the pathway with ITS2 first cleavage of the 35S pre-rRNA transcript. Moreover, we realized that 5’-5.8S processing is essential, while a mutant causing 6S accumulation shows only a weak phenotype. Thus, we demonstrate the importance of the maturation of the plant-specific precursor 5’-5.8S for plant development as well as the occurrence of an ITS2 first cleavage pathway in fast dividing tissues.
Trying to be perfect in an imperfect world: A person-centred test of perfectionism and health in fibromyalgia patients versus healthy controls
Sirios , F. ; Toussaint, L.; Hirsch, J. K.; Kohls, Niko; Weber, Annemarie; Offenbächer, M. (2019)
Sirios , F. ; Toussaint, L.; Hirsch, J. K.; Kohls, Niko; Weber, Annemarie...
Personality and Individual Differences, 137, 27-32. doi: https://doi.org/10.1016/j.paid.2018.08.005, 27-32.
DOI: 10.1016/j.paid.2018.08.005
Peer Reviewed
Lab on a Chip
Drese, Klaus Stefan (2019)
Wiener klinisches Magazin 2019 22 (4), 172–177.
DOI: 10.1007/s00740-019-0286-x
Machine Learning in der Qualitätskontrolle
Fairuschin, Viktor; Drese, Klaus Stefan (2019)
Jahresmagazin Mess- und Sensortechnik 2019, 36–38.
Nichtinvasive Detektion von Biofilmen in der Hausinstallation.
Tietze, Sabrina; Lasota, Sandra; Ebert, S.; Landskron, J.; Schwuchow, K.; Drese, Klaus Stefan (2019)
Tietze, Sabrina; Lasota, Sandra; Ebert, S.; Landskron, J.; Schwuchow, K....
Verivita Symposium Hygiene + Technik / Wetzlar 2019, 21–27.
Measure particulate matter by yourself: data-quality monitoring in a citizen science project
Benabbas, A.; Geißelbrecht, M.; Nikol, G.; Mahr, L.; Nähr, D.; Steuer, S.; Wiesemann, G.; Müller, T.; Nicklas, D.; Wieland, Thomas (2019)
Benabbas, A.; Geißelbrecht, M.; Nikol, G.; Mahr, L.; Nähr, D.; Steuer, S....
Journal of Sensor and Sensor Systems (J. Sens. Sens. Syst.) 2019 8 (2), 317–328.
DOI: 10.5194/jsss-8-317-2019
Peer Reviewed
Sicherheit statt Freiheit?! - Einsatz freiheitsentziehender Maßnahmen (FEM) in der Pflege von Menschen mit Demenz.
Berzlanovich, A.; Kohls, Niko (2019)
Demenz - Prävention und Therapie / Essen 2019, 439–448.
Rechtsphilosophische Horizonte und die Globalisierung
Buchholz-Schuster, Eckardt (2019)
Über den Horizont / Berlin, Boston 2019 (5), 191–212.
DOI: 10.1515/9783110553291-012
Numerical Verification of the Thermodynamic Determination of the Hydraulic Efficiency of Radial Fans
Epple, Philipp; Fritsche, Manuel; Reinker, F.; Wiesche, S. aus der (2019)
Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition IMECE2019-11417 2019.
DOI: 10.1115/IMECE2019-11417
Theoretical and Numerical Analysis of the Pressure Distribution and Discharge Velocity in Flows under inclined Sluice Gates
Epple, Philipp; Steppert, Michael; Malcherek, A.; Fritsche, Manuel (2019)
Proceedings of the ASME - JSME - KSME Joint Fluids Engineering Conference 2019, AJKFLUIDS2019-4613 2019.
Peer Reviewed
Über den Horizont
Frischmann, B.; Holtorf, Christian (2019)
SpatioTemporality / RaumZeitlichkeit / Berlin, Boston 2019 (5).
DOI: 10.1515/9783110553291
Numerical Investigation of the Euler Turbomachinery Equation and Analysis of the Impact of the Impeller Design on the Fan Performance by Optimization Study
Fritsche, Manuel; Epple, Philipp; Gast, Stefan; Delgado, A. (2019)
Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition IMECE2019-11417 2019.
CFD-Simulation of Centrifugal Fan Performance Characteristics Using Ideal and Real Gas Models for Air and Organic Fluids
Fritsche, Manuel; Epple, Philipp; Hasselmann, K.; Reinker, F.; Wagner, R.; Wiesche, S. aus der (2019)
Fritsche, Manuel; Epple, Philipp; Hasselmann, K.; Reinker, F.; Wagner, R....
Proceedings of the ASME - JSME - KSME Joint Fluids Engineering Conference 2019, AJKFLUIDS2019-4613 2019.
Phage display selection of InIA-binding ligands for Listeria monocytogenes - potential tools for diagnosis or therapy of listeriosis
Funke, Susanne A.; Kenzel, Julia (2019)
Pharmaceutical Microbiology 2019.
Peer Reviewed
Live and Let Die: On the Management of Creativity
Hartmann, Michael; Laubengaier, D.; Foerstl, K. (2019)
Technology Innovation Management Review 2019 9 (10), 16–26.
DOI: 10.22215/timreview/1272
Peer Reviewed
Perceived stigma and health-related quality of life in the working uninsured: Does thwarted belongingness play a role?
Hirsch, J. K.; Sirois, F. M.; Visser, P.; Brooks, B.; Kohls, Niko; Offenbächer, M.; Toussaint, L. (2019)
Hirsch, J. K.; Sirois, F. M.; Visser, P.; Brooks, B.; Kohls, Niko; Offenbächer, M....
Stigma and Health 2019 4 (1), 1–10.
DOI: 10.1037/sah0000116
Peer Reviewed
Fibromyalgia impact and depressive symptoms: Can perceiving a silver lining make a difference?
Hirsch, J. K.; Treaster, M.; Kaniuka, A.; Brooks, B.; Sirois, F. M.; Kohls, Niko; Nöfer, Eberhard; Toussaint, L.; Offenbächer, M.; Treaster, M. K.; Kaniuka, A. R.; Brooks, B. D. (2019)
Hirsch, J. K.; Treaster, M.; Kaniuka, A.; Brooks, B.; Sirois, F. M.; Kohls, Niko...
Scandinavian Journal of Psychology 2019.
DOI: 10.1111/sjop.12598
Peer Reviewed
Individuals with fibromyalgia are at greater risk for depressive symptoms than the general population, and this may be partially attributable to physical symptoms that impair day-to-day functioning. However, individual-level protective characteristics may buffer risk for psychopathology. For instance, the ability to perceive a "silver lining" in one`s illness may be related to better mental and physical health. We examined perceived silver lining as a potential moderator of the relation between fibromyalgia impact and depressive symptoms. Our sample of persons with fibromyalgia (N = 401) completed self-report measures including the Fibromyalgia Impact Questionnaire-Revised, Depression Anxiety Stress Scales, and the Silver Lining Questionnaire. Moderation analyses covaried age, sex, and ethnicity. Supporting hypotheses, increasing impact of disease was related to greater depressive symptoms, and perceptions of a silver lining attenuated that association. Despite the linkage between impairment and depressive symptoms, identifying positive aspects or outcomes of illness may reduce risk for psychopathology. Therapeutically promoting perception of a silver lining, perhaps via signature strengths exercises or a blessings journal, and encouraging cognitive reframing of the illness experience, perhaps via Motivational Interviewing or Cognitive Behavioral Therapy, may reduce depressive symptoms in persons with fibromyalgia.
Ein arktischer Ozean: Josef Chavanne, das ,ewige Eis` und die Vorläufer der Klimadiagramme
Holtorf, Christian (2019)
In: Jens Ruppenthal/Ruth Schilling/Martin Weiss (Hg.): Von Flaschenpost bis Fischreklame 2019, 25–45.
Horizonterweiterung als wissenschaftliche Selbstreflexion
Holtorf, Christian (2019)
In: Christian Holtorf, Bärbel Frischmann (Hg.): "Über den Horizont. Standorte, Grenzen und Perspektiven". 2019, 165–189.