Mobilität
Wilde, Mathias (2022)
Schlüsselbegriffe der Sozialplanung und ihre Kritik (= Sozialraumforschung und Sozialraumarbeit), 117-127.
DOI: 10.1007/978-3-658-38399-2_9
Peer Reviewed
Digital skills for Heritage Conservation
Troi, Alexandra; Hess, Mona ; Huth, Olaf; Jagfeld, Matthias (2022)
www.buildup.eu.
Open Access Peer Reviewed
Digitalisation and digital technologies present a great opportunity for Heritage Conservation, particularly regarding our Built Heritage and its sustainable use. Professionals are needed who can understand and quantify the complex physical processes required with the help of digital tools and will collaborate with their analysis to interdisciplinary dialogue before any conservation-related decision is made.
Towards a guide for developers and novice researchers on human-centered design of the take-over request—Combining user experience and human factors
Lindner, Alisa; Stoll, Tanja (2022)
Zeitschrift für Arbeitswissenschaften 77, 111–125.
Open Access Peer Reviewed
DocFin: Multimodal Financial Prediction and Bias Mitigation using Semi-structured Documents
Mathur, Puneet; Goyal, Mihir; Sawhney, Ramit; Mathur, Ritik; Leidner, Jochen L.; Dernoncourt, Franck; Manocha, Dinesh (2022)
Mathur, Puneet; Goyal, Mihir; Sawhney, Ramit; Mathur, Ritik; Leidner, Jochen L....
Findings of the Association for Computational Linguistics: EMNLP 2022 (Empirical Methods in Natural Language Processing), December 2022, Abu Dhabi, United Arab Emirates, 1933-1940.
Open Access Peer Reviewed
Financial prediction is complex due to the stochastic nature of the stock market. Semi-structured financial documents present comprehensive financial data in tabular formats, such as earnings, profit-loss statements, and balance sheets, and can often contain rich technical analysis along with a textual discussion of corporate history, and management analysis, compliance, and risks. Existing research focuses on the textual and audio modalities of financial disclosures from company conference calls to forecast stock volatility and price movement, but ignores the rich tabular data available in financial reports. Moreover, the economic realm is still plagued with a severe under-representation of various communities spanning diverse demographics, gender, and native speakers. In this work, we show that combining tabular data from financial semi-structured documents with text transcripts and audio recordings not only improves stock volatility and price movement prediction by 5-12% but also reduces gender bias caused due to audio-based neural networks by over 30%.
Praxis der Kinderrechte an deutschen Schulen. Eine Zwischenbilanz.
Lohrenscheit , Claudia (2022)
Buch 2023.
Dark side of a bio-based and biodegradable plastic? Assessment of pathogenic microbes associated with poly(butylene succinate-co-adipate) under ambient and future climates using next-generation sequencing
Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Tongsuk, K.; Schädler , M.; Noll, Matthias; Purahong, W. (2022)
Juncheed , K.; Tanunchai, Benjawan; Wahdan, S. F. M.; Tongsuk, K.; Schädler , M....
Frontiers in Plant Science 13, 966363.
DOI: 10.3389/fpls.2022.966363
Open Access Peer Reviewed
tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions
Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin; Mochmann, Liliana; Rad, Pegah; Weiss, Stefan; Simm, Stefan; Zeller, Tanja; Voelzke, Henry; Hoffmann, Wolfgang; Völker, Uwe; Felix, Stefan; Dörr, Marcus; Beling, Antje; Skurk, Carsten; Leistner, David-Manuel; Rauch, Bernhard; Hirose, Tetsuro; Heidecker, Bettina; Klingel, Karin; Nakagawa, Shinichi; Poller, Wolfram; Swirski, Filip; Haghikia, Arash; Poller, Wolfgang (2022)
Gast, Martina; Nageswaran, Vanasa; Kuss, Andreas; Tzvetkova, Ana; Wang, Xiaomin...
Cells 11 (24), 3970.
DOI: 10.3390/cells11243970
Open Access Peer Reviewed
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions have been assigned to the nuclear transcripts, data on biological functions of the small cytosolic transcripts are sparse. We previously found NEAT1-/- and MALAT1-/- mice to display massive atherosclerosis and vascular inflammation. Here, employing selective targeted disruption of menRNA or mascRNA, we investigate the tRNA-like molecules as critical components of innate immunity. CRISPR-generated human ΔmascRNA and ΔmenRNA monocytes/macrophages display defective innate immune sensing, loss of cytokine control, imbalance of growth/angiogenic factor expression impacting upon angiogenesis, and altered cell-cell interaction systems. Antiviral response, foam cell formation/oxLDL uptake, and M1/M2 polarization are defective in ΔmascRNA/ΔmenRNA macrophages, defining first biological functions of menRNA and describing new functions of mascRNA. menRNA and mascRNA represent novel components of innate immunity arising from the noncoding genome. They appear as prototypes of a new class of noncoding RNAs distinct from others (miRNAs, siRNAs) by biosynthetic pathway and intracellular kinetics. Their NEAT1-MALAT1 region of origin appears as archetype of a functionally highly integrated RNA processing system.
Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio; Bosch, Thomas; Wenck, Horst; Winnefeld, Marc; Grönniger, Elke; Simm, Stefan; Siracusa, Annette (2022)
Gather, Leonie; Nath, Neetika; Falckenhayn, Cassandra; Oterino-Sogo, Sergio...
The Journal of Investigative Dermatology 142 (12), 3136–3145.e11.
DOI: 10.1016/j.jid.2022.06.023
Open Access Peer Reviewed
Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and adequately respond to external stressors. Macrophages are important gatekeepers of tissue homeostasis, and it has been reported that their number and phenotype change during aging in a site-specific manner. How aging affects human skin macrophages and what implications this has for the aging process in the tissue are still not fully understood. Using single-cell RNA-sequencing analysis, we show that there is at least a 50% increase of macrophages in human aged skin, which appear to have developed from monocytes and exhibit more proinflammatory M1-like characteristics. In contrast, the cell-intrinsic ability of aged monocytes to differentiate into M1 macrophages was reduced. Using coculture experiments with aged dermal fibroblasts, we show that it is the aged microenvironment that drives a more proinflammatory phenotype of macrophages in the skin. This proinflammatory M1-like phenotype in turn negatively influenced the expression of extracellular matrix proteins by fibroblasts, emphasizing the impact of the aged macrophages on the skin phenotype.
Unspezifische Effekte von Operationen – Erkenntnisse aus der Placeboforschung
Meißner, Karin (2022)
Eingeladener Vortrag, Gründungsveranstaltung für das REGIOMED Zentrum für Wirbelsäulenmedizin, Regiomed Klinikum Lichtenfels .
Deep omics profiling of diabetic bone regeneration – Dysregulated molecular mechanisms and implications for personalized PCL-scaffold design
Kalkhof, Stefan (2022)
e:Med Meeting 2022 on Systems Medicine November 28-30, 2022 Heidelberg, DKFZ Communication Center.
Links among microbial communities, soil properties, and functions: Are fungi the sole players in the decomposition of bio-based and biodegradable plastic?
Guliyev , V.; Tanunchai, Benjawan; Noll, Matthias; Buscot, F.; Purahong, W.; Blagodatskaya , E. (2022)
Guliyev , V.; Tanunchai, Benjawan; Noll, Matthias; Buscot, F.; Purahong, W....
MDPI Polymers 14, 2801.
DOI: 10.3390/polym14142801
Open Access Peer Reviewed
Creditions in prevention and treatment: lessons learned from two empirical studies
Meißner, Karin (2022)
Vortrag auf der internationalen Tagung "The structure of creditions - methods, methodology, and assessment", Graz, Österreich.
What is NLP and What Trends Can We See in 2022?
Leidner, Jochen L. (2022)
Invited Talk, Joint Webinar of the CFA organization (French Chapter) and the London Stock Exchange Group (LSEG), London/Paris/online, November 18, 2022.
Drivers of deadwood decay of 13 temperate tree species are similar between forest and grassland habitats
Kipping, Lydia; Maurer, Florian; Gossner, Martin M.; Muszynski, Sarah; Kahl, Tiemo; Kellner, H.; Weisser, Wolfgang W.; Jehmlich, N.; Noll, Matthias (2022)
Kipping, Lydia; Maurer, Florian; Gossner, Martin M.; Muszynski, Sarah; Kahl, Tiemo...
Frontiers in Forest & Global Change 5, 1020737.
DOI: 10.3389/ffgc.2022.1020737
Peer Reviewed
Kulturstrategie – Coburg macht sich auf den Weg!
Gross, Hellen (2022)
Vortrag auf dem Kulturworkshop „Kultur in Coburg - Zukunft gemeinsam gestalten“ auf Einladung der Kulturbeauftragten des Stadtrates zu Coburg Antoinetta Bafas.
A systematic review to evaluate the stress relieving potential of qigong, taiji and acupressure
Meißner, Karin (2022)
Oral presentation, 2022 Xing-lin International Week of Chengdu University of Traditional Chinese Medicine (CDUTCM).
Selection of Listeria monocytogenes InlA-Binding Peptides Using Phage Display—Novel Compounds for Diagnostic Applications?
Kenzel, Julia; Brüggemann, Dagmar Adeline; Funke, Susanne A. (2022)
Applied Microbiology 2022 (4), 2 | 921-933.
DOI: 10.3390/applmicrobiol2040070
Open Access
Placebo effects in medicine
Meißner, Karin (2022)
Vortrag im Rahmen der Vorlesungsreihe "Hot Topics in Psychology", TUM Fakultät für Sport- und Gesundheitswissenschaften.
Energieeffizienz von Rückförderpumpen in Meerwasser-Aquarien. Teil 1: System-Gestaltung.
Schaub, Michael (2022)
Korallenriff-Magazin 11, 28-33.
DOI: 10.13140/RG.2.2.21894.65605
Open Access
Wie können IVF-Behandlungen weniger belastend gestaltet werden? Eine qualitative Studie zu den Erwartungen, Erfahrungen und Belastungen von Frauen mit wiederholt erfolglosen IVF-Behandlungen sollte Ansatzpunkte für Verbesserungen aufzeigen
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie; Olliges, Elisabeth; Kraft, Jana; Popovici, R. M.; Meißner, Karin (2022)
Huber, Jana; Lotz-Schmidt, Katharina; Bobinger, Alina; Weber, Annemarie...
Frauenarzt - Offizielles Organ des Berufsverbands der Frauenärzte e.V. (BVF) sowie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e.V. (DGGG) 63 (11), 722 – 726.