Die Auswirkungen einer 8-wöchigen Yoga-Intervention auf Angst und stressbedingte Symptome bei Brustkrebspatientinnen nach der Akutbehandlung: Protokoll einer randomisierten kontrollierten Studie
Hiller, Annika; Iser, Lilli; Schulz, Juliane; Antwerpen, Cornelia (2025)
DGMP/DGMS Kongress, Jena, Germany. .
Peer Reviewed
Prädiktoren der Effektivität VR-basierter Interventionen zur Stressreduktion: Ein systematisches Review mit Metaanalyse
Strauch, Hannah; Schuil, Isabel; Simm, Stefan; Grubert, Jens; Kalamkar, Snehanjali (2025)
DGMP/DGMS Kongress, Jena, Germany.
Peer Reviewed
Effekte von multisensorischem virtuellem Waldbaden auf Stress und Wohlbefinden von gesunden Erwachsenen – eine randomisierte kontrollierte Studie
Schuil, Isabel; Kalamkar, Snehanjali; Simm, Stefan; Grubert, Jens; Streuber, Stephan (2025)
Schuil, Isabel; Kalamkar, Snehanjali; Simm, Stefan; Grubert, Jens...
DGMP/DGMS Kongress, Jena, Germany.
Single-cell RNA sequencing delineates renal anti-fibrotic mechanisms mediated by TRPC6 inhibition
Xu, Yao; Zheng, Zhihuang; Oswald, Marleen; Cheng, Guozhe; Liu, Jun; Zhai, Qidi; Kruegel, Ute; Schaefer, Michael; Gerhardt, Holger; Endlich, Nicole; Gollasch, Maik; Simm, Stefan; Tsvetkov, Dmitry (2025)
Xu, Yao; Zheng, Zhihuang; Oswald, Marleen; Cheng, Guozhe; Liu, Jun; Zhai, Qidi...
Adv. Sci. (Weinh.) 12 (33), e01175.
Peer Reviewed
Chronic kidney disease (CKD) is characterized by persistent inflammation and tubulointerstitial fibrosis leading to end-stage renal disease. Transient receptor potential canonical 6 (TRPC6) channel inhibition mitigates tubular injury and renal fibrosis in murine models of unilateral ureteral obstruction (UUO) and 2-month chronic post-ischemia-reperfusion injury (2m post-I/R). Through integrated analysis of single-cell-RNA-sequencing (scRNA-Seq) data from UUO mice treated with the selective TRPC6 inhibitor SH045, here the renoprotective cell composition and cell type-specific transcriptional programs are defined. We explored translational aspects by conducting an in-depth scRNA-Seq analysis of kidney samples from patients with CKD. These results reveal global transcriptional shifts with a dramatic diversification of inflammatory cells, endothelial cells and fibroblasts. Notably, a distinct subpopulation of novel endothelial cells is delineated, which is termed ECRIN, that regulate inflammatory networks implicating VEGF and GAS signaling pathways. The data also indicates that inhibition of TRPC6 channels triggers a Prnp transcription factor regulatory network, which contributes to the alleviation of renal fibrosis. The key findings are supported at the protein level by immunofluorescence and western blot analysis. We observed similar patterns in the chronic 2m postI/R injury model. These findings provide novel insights into the potential therapeutic benefits of TRPC6 inhibition in CKD.
Plasma-treated water applied as a foliar spray promotes root growth in barley
Krüger, Andrea; Schlömer, Stefan; Simm, Stefan; Bold, Jessica; Stöhr, Christine (2025)
BMC Plant Biol. 25 (1), 1210.
Open Access Peer Reviewed
Symptoms of post-traumatic distress and quality of life in adults with aortopathy and congenital heart defects or hereditary connective tissue diseases
Dreher, Helena; Dewald, Oliver; Freiberger, Annika; Freilinger, Sebastian; Harig, Frank; Nagdyman, Nicole; Strueven, Nina; Suleiman, Mathieu; Mellert, Fritz; Kohls, Niko; Kaemmerer-Suleiman, Ann-Sophie (2025)
Dreher, Helena; Dewald, Oliver; Freiberger, Annika; Freilinger, Sebastian; Harig, Frank...
Cardiovascular Diagnosis and Therapy 0 (0).
Open Access Peer Reviewed
Auch wissentlich verabreichte Placebos zeigen Wirkung
Meißner, Karin (2025)
Interview in der Sendung "Welt am Abend", Bayern 2 .
Encapsulated biocides in façade materials impact leaching and UV stability, resulting in lower aquatic toxicity of the eluates
Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine; Noll, Matthias; Kalkhof, Stefan (2025)
Nichterlein, Moritz; Kiefer, Nadine; Hohner, Jenny; Stapf, D.; Schatz, Madeleine...
Environmental Science and Pollution Research 2025 (32), 16324-16339.
DOI: 10.1093/etojnl/vgaf156
Peer Reviewed
Neuroenhancement unter Studierenden im ländlichen Raum–eine Querschnittstudie zu Prävalenz, Genderunterschieden und Beweggründen
Engel, Katharina; Meißner, Karin (2025)
Prävention und Gesundheitsförderung 20 (3), 421-427.
DOI: 10.1007/s11553-024-01139-7
Open Access Peer Reviewed
Sitzt die Hüftprothese? Lockerungserkennung mit Ultraschall
Lützelberger, Jan; Franck, Alexander; Drese, Klaus Stefan (2025)
Zeitungsartikel, Management & Krankenhaus 8-9, 2025..
Systematic Comparison of Bone Proteome Extraction Methods to Allow for Integrated Proteomics–Metabolomics Correlation
Wiltzsch, Vivien; Schmidt, Johannes; Adamowicz, Klaudia; Lauterbach, Theresa; Lehmann, Jörg; Baumbach, Jan; Laske, Tanja; Kalkhof, Stefan (2025)
Wiltzsch, Vivien; Schmidt, Johannes; Adamowicz, Klaudia; Lauterbach, Theresa...
Journal of Proteome Research 24 (9), 4362–4376.
DOI: 10.1021/acs.jproteome.4c01060
Peer Reviewed
Neurocognitive Factors in Spiritual Experiences and Practices
Kohls, Niko; Giordano, James (2025)
, 1–13.
DOI: 10.1007/978-3-031-38971-9_1976-1
Peer Reviewed
Psychologie des Älterwerdens
Kohls, Niko (2025)
Wissen für Alle by Hochschule Coburg: Mit 66 Jahren .... Äter werden mit Qualität.
Forgiveness and Physical Health: A Review of Theory and Evidence
Toussaint, Loren; Webb, Jon; Hirsch, Jameson; Kohls, Niko; Offenbaecher, Martin; Dezutter, Jessie; Nguyen, Quang; Vallejo, Miguel; Sirois, Fuschia (2025)
Toussaint, Loren; Webb, Jon; Hirsch, Jameson; Kohls, Niko; Offenbaecher, Martin...
, 245–268.
DOI: 10.1007/978-3-031-89095-6_11
Peer Reviewed
This chapter offers an overview of the forgiveness and health connection. We offer a review of common ways to define forgiveness of others and self-forgiveness. Stress-and-coping theories of forgiveness of others and self-forgiveness are outlined. Both theories consider antecedents, correlates, and health outcomes of forgiveness of others and self-forgiveness and both offer a comprehensive and interpretive lens through which to view empirical research on associations between forgiveness of others and self-forgiveness with health outcomes. In reviewing 73 studies, we found seventy-five percent showed at least one connection between a dimension of forgiveness and a physical health outcome. We conclude by integrating and interpreting the research literature, identifying caveats and limitations, and offering a research agenda. Researchers and practitioners are encouraged to think broadly and model forgiveness-health relationships on established psychological and health theories and to execute theory-guided studies of the forgiveness and health connection.
Heilung ohne Wirkstoff: Wissenschaftliche Hintergründe und klinische Anwendungen des Placeboeffekts
Meißner, Karin (2025)
Gastvorlesung am Institut für Medizinische Psychologie, Medizinische Fakultät, LMU München.
Droplet-Based Measurements of DNA-Templated Nanoclusters—Towards Point-of-Care Applications
Kluitmann, Jonas; Di Fiore, Stefan; Nölke, Greta; Drese, Klaus Stefan (2025)
Biosensors 15 (7), 417.
DOI: 10.3390/bios15070417
Open Access
Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system
Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel; Schmidt, Johannes; Simm, Stefan; Kalkhof, Stefan; Hildebrand, Janosch; Bosch, Thomas; Winnefeld, Marc; Grönniger, Elke; Siracusa, Annette (2025)
Ritter, Johanna; Falckenhayn, Cassandra; Qi, Minyue; Gather, Leonie; Gutjahr, Daniel...
Aging (Albany NY) 17 (7), 1784–1809.
Peer Reviewed
Aging is a complex process that significantly contributes to age-related diseases and poses significant challenges for effective interventions, with few holistic anti-aging approaches successfully reversing its signs. Heterochronic parabiosis studies illuminated the potential for rejuvenation through blood-borne factors, yet the specific drivers including underlying mechanisms remain largely unknown and until today insights have not been successfully translated to humans. In this study, we were able to recreate rejuvenation of the human skin via systemic factors using a microphysiological system including a 3D skin model and a 3D bone marrow model. Addition of young human serum in comparison to aged human serum resulted in an improvement of proliferation and a reduction of the biological age as measured by methylation-based age clocks in the skin tissue. Interestingly, this effect was only visible in the presence of bone marrow-derived cells. Further investigation of the bone marrow model revealed changes in the cell population in response to young versus aged human serum treatment. Using proteome analysis, we identified 55 potential systemic rejuvenating proteins produced by bone marrow-derived cells. For seven of these proteins, we were able to verify a rejuvenating effect on human skin cells using hallmarks of aging assays, supporting their role as systemic factors rejuvenating human skin tissue.
Privacy-preserving multicenter differential protein abundance analysis with FedProt
Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine; Barth, Teresa; Schweizer, Lisa; Giesbertz, Pieter; Schmidt, Johannes; Kalkhof, Stefan; Müller-Deile, Janina; van Veelen, Peter; Mohammed, Yassene; Hammer, Elke; Arend, Lis; Adamowicz, Klaudia; Laske, Tanja; Hartebrodt, Anne; Frisch, Tobias; Meng, Chen; Matschinske, Julian; Späth, Julian; Röttger, Richard; Schwämmle, Veit; Hauck, Stefanie; Lichtenthaler, Stefan; Imhof, Axel; Mann, Matthias; Ludwig, Christina; Kuster, Bernhard; Baumbach, Jan; Zolotareva, Olga (2025)
Burankova, Yuliya; Abele, Miriam; Bakhtiari, Mohammad; von Toerne, Christine...
Nature Computational Science 5 (8), 675–688.
DOI: 10.1038/s43588-025-00832-7
Peer Reviewed
Ultraschall-Check für die Hüftprothese
Lützelberger, Jan (2025)
Vortrag, Interdisziplinäres Wissenschaftliches Kolloquium an der Hochschule Coburg, Coburg, 2025.
Placebo Interventions to Modulate Appetite: Sex-Specific Psychobiological and Cognitive Responses
Symposium "Exploring the World of Appetite: How Placebo and Nocebo Impact Hunger, Food Preferences, and Weight Changes" (Żegleń M, Meissner K, Schmidt L), 5th International Conference of the Society for Interdisciplinary Placebo Studies (SIPS), Krakau, Polen.
Peer Reviewed
Fakultät Angewandte Naturwissenschaften und Gesundheit (FNG)
Hochschule Coburg
Friedrich-Streib-Str. 2
96450 Coburg
Monika Schnabel
Forschungsreferentin, EU-Referentin
T +49 9561 317 8062
monika.schnabel[at]hs-coburg.de