Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF: Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease

Funke, Susanne A. (2011)

Int J Alzheimers Dis .
DOI: 10.4061/2011/151645

Combining independent drug classes into superior, synergistically acting hybrid molecules

Müller-Schiffmann, A.; März-Berberich , Julia; Andreyeva , Aksana ; Rönicke , Raik ; Bartnik , Dirk ; Brener, Oleksandr; Kutzsche, Janine; Horn, A. H. C.; Hellmerth , Marco ; Polkowska , Jolenta ; Gottmann, Kurt; Reymann, Klaus G.; Funke, Susanne A.; Nagel-Steger, Luitgard; Moriscot , Christine; Schoehn , Guy ; Sticht, H.; Willbold, Dieter; Schrader, Thomas ; Korth , C. (2010)

Müller-Schiffmann, A.; März-Berberich , Julia; Andreyeva , Aksana ; Rönicke , Raik ...

Angew Chem Int Ed Engl 49.
DOI: 10.1002/anie.201004437

Transport of Alzheimer disease amyloid-beta-binding D-amino acid peptides across an in vitro blood-brain barrier model

Liu, Hongmei ; Funke, Susanne A.; Willbold, Dieter (2010)

Rejuvenation Res. 13, , 210-213..
DOI: 10.1089/rej.2009.0926

Competitively selected protein ligands pay their increase in specificity by a decrease in affinity

Hoffmann, Silke; Funke, Susanne A.; Wiesehan , Katja ; Moedder, Susanne; Glück , J. M. ; Feuerstein , Sophie; Gerdts , Matthias ; Mötter, Jessica ; Willbold, Dieter (2010)

Hoffmann, Silke; Funke, Susanne A.; Wiesehan , Katja ; Moedder, Susanne...

Mol. Biosyst. 6, , 126-133..
DOI: 10.1039/B910945E

Oral Treatment with the D-Enantiomeric Peptide D3 Improves Pathology and Behavior of Alzheimer’s disease Transgenic

Funke, Susanne A.; van Groen, Thomas; Kadish, Inga; Bartnik , Dirk ; Nagel-Steger, Luitgard; Brener, Oleksandr; Sehl, Torsten ; Batra-Safferling , Renu ; Moriscot , Christine; Schoehn , Guy ; Horn, A. H. C.; Müller-Schiffmann, A.; Korth , C.; Sticht, H.; Willbold, Dieter (2010)

Funke, Susanne A.; van Groen, Thomas; Kadish, Inga; Bartnik , Dirk ...

ACS Chem. Neurosci. 2010, 1, 9, 639–648, 639–648.
DOI: 10.1021/cn100057j

Single particle detection system for Aß: Adaptation of surface-FIDA to laser scanning microscopy.

Funke, Susanne A.; Wang, L.; Birkmann, Eva; Willbold, Dieter (2010)

Rejuvenation Res. 13, , 206-209..

Differently selected D-enantiomeric peptides act on different Aß species.

Bartnik , Dirk ; Funke, Susanne A.; Andrei-Selmer, L-C; Bacher, M.; Dodel, R.; Willbold, Dieter (2010)

Bartnik , Dirk ; Funke, Susanne A.; Andrei-Selmer, L-C; Bacher, M.; Dodel, R....

Rejuvenation Res. 13, 202-205.

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

Schlenzig, Dagmar; Manhart, Susanne; Cinar, Yeliz ; Kleinschmidt , Martin ; Hauser, Gerd ; Willbold, Dieter; Funke, Susanne A.; Schilling , Stephan ; Demuth, Hans-Ulrich (2009)

Schlenzig, Dagmar; Manhart, Susanne; Cinar, Yeliz ; Kleinschmidt , Martin ...

Biochemistry 2009, 48, 29, , 7072–7078.
DOI: 10.1021/bi900818a

Detection of Amyloid-β Aggregates in Body Fluids: A Suitable Method for Early Diagnosis of Alzheimer's Disease?

Funke, Susanne A.; Birkmann, Eva; Willbold, Dieter (2009)

Current Alzheimer Research 6, 3 | 285-289.
DOI: 10.2174/156720509788486536

Transient reduction of spontaneous neuronal network activity by sublethal amyloid beta (1-42) peptide concentrations

Görtz, Philipp; Opatz, Jessica; Siebler, Mario ; Funke, Susanne A.; Willbold, Dieter; Lange-Asschenfeldt , Chtistian (2009)

Görtz, Philipp; Opatz, Jessica; Siebler, Mario ; Funke, Susanne A.; Willbold, Dieter...

Journal of Neural Transmission volume 116, 351–355.
DOI: 10.1007/s00702-009-0188-y

In vitro and in vivo Staining Characteristics of Small, Fluorescent, Aβ42-Binding D-Enantiomeric Peptides in Transgenic AD Mouse Models

van Groen, Thomas; Kadish, Inga; Wiesehan , Katja ; Funke, Susanne A.; Willbold, Dieter (2009)

van Groen, Thomas; Kadish, Inga; Wiesehan , Katja ; Funke, Susanne A....

ChemMedChem Volume 4, Issue 2 4, 2 | 276-282.
DOI: 10.1002/cmdc.200800289

Mirror image phage display - a method to generate D-peptide ligands for use in diagnostic or therapeutical applications?

Funke, Susanne A.; Willbold, Dieter (2009)

Molecular BioSystems 5, 783 - 786.
DOI: 10.1039/b904138a

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

van Groen, Thomas; Wiesehan , Katja ; Funke, Susanne A.; Kadish, Inga; Nagel-Steger, Luitgard; Willbold, Dieter (2008)

van Groen, Thomas; Wiesehan , Katja ; Funke, Susanne A.; Kadish, Inga...

ChemMedChem Volume 3, Issue 12 3, 12 | 1848-1852.
DOI: 10.1002/cmdc.200800273

A highly sensitive diagnostic assay for aggregate-related diseases, including prion diseases and Alzheimer's disease

Birkmann, Eva; Henke, Franziska; Funke, Susanne A.; Bannach , Oliver; Riesner, Detlev; Willbold, Dieter (2008)

Birkmann, Eva; Henke, Franziska; Funke, Susanne A.; Bannach , Oliver; Riesner, Detlev...

Rejuvenation Research 11, 2 | 359-363..
DOI: 10.1089/rej.2008.0697

Evolution of Enantioselective Bacillus subtilis Lipase

Eggert, Thorsten ; Funke, Susanne A.; Andexer , JN; Reetz , Manfred T. ; Jaeger, Karl-Erich (2008)

Eggert, Thorsten ; Funke, Susanne A.; Andexer , JN; Reetz , Manfred T. ...

book chapter in: Protein Engineering Handbook, 1. Auflage 2008.

Single particle detection of Aβ aggregates associated with Alzheimer’s disease

Funke, Susanne A.; Birkmann, Eva; Henke, Franziska; Görtz, Philipp; Lange-Asschenfeldt , Chtistian ; Riesner, Detlev; Willbold, Dieter (2007)

Funke, Susanne A.; Birkmann, Eva; Henke, Franziska; Görtz, Philipp...

Biochemical and Biophysical Research Communications 364, 4 | 902-907.
DOI: 10.1016/j.bbrc.2007.10.085

Counting of single prion particles bound to a capture-antibody surface (surface-FIDA)

Birkmann, Eva; Henke, Franziska; Weinmann, Nicole ; Dumpitak , Christian ; Groschup , Martin ; Funke, Susanne A.; Funke, Susanne A.; Willbold, Dieter; Riesner, Detlev (2007)

Birkmann, Eva; Henke, Franziska; Weinmann, Nicole ; Dumpitak , Christian ...

Veterinary Microbiology 123, 4 | 294-304.
DOI: 10.1016/j.vetmic.2007.04.001

Purification of recombinantly expressed and cytotoxic human amyloid-beta peptide 1-42

Wiesehan , Katja ; Funke, Susanne A.; Miriam , Fries ; Willbold, Dieter (2007)

Journal of Chromatography B 856, 1-2 | 229-233.
DOI: 10.1016/j.jchromb.2007.06.003

Development of an ultra-sensitive assay for early diagnosis of Alzheimer's disease

Funke, Susanne A.; Birkmann, Eva; Henke, Franziska; Riesner, Detlev (2007)

BMC Neuroscience 8, P24.
DOI: 10.1186/1471-2202-8-S1-P24

Combination of computational prescreening and experimental library construction can accelerate enzyme optimization by directed evolution

Funke, Susanne A.; Otte , Nikolaj ; Eggert, Thorsten ; Bocola, Marco ; Jaeger, Karl-Erich ; Thiel , Walter (2005)

Funke, Susanne A.; Otte , Nikolaj ; Eggert, Thorsten ; Bocola, Marco ...

Protein Engineering, Design and Selection 18, 11 | 509-514.
DOI: 10.1093/protein/gzi062